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DTYMK is essential for genome integrity and neuronal survival
Nucleotide metabolism is a complex pathway regulating crucial cellular processes such as nucleic acid synthesis, DNA repair and proliferation. This...
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CRISPR/Cas9-engineered Gad1 elimination in rats leads to complex behavioral changes: implications for schizophrenia
GABAergic dysfunctions have been implicated in the pathogenesis of schizophrenia, especially the associated cognitive impairments. The GABA synthetic...
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Increased Fungal Infection Mortality Induced by Concurrent Viral Cellular Manipulations
Certain respiratory fungal pathogen mono-infections can cause high mortality rates. Several viral pathogen mono-infections, including influenza...
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Advances in brain epitranscriptomics research and translational opportunities
Various chemical modifications of all RNA transcripts, or epitranscriptomics, have emerged as crucial regulators of RNA metabolism, attracting...
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Scrutinizing pharmacological efficiency for Acacia auriculiformis by experimental and computational approach
BackgroundThe study sought to investigate the biological efficacy of methanol leave extract of Acacia auriculiformis (MEAA) via in vitro, in vivo,...
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CRISPR/Cas9 Mediated Deletion of the Uox Gene Generates a Mouse Model of Hyperuricemia with Multiple Complications
Hyperuricemia is a common metabolic disorder with severe complications. We aimed to develop a mouse model for spontaneous hyperuricemia. Uox -/- mouse...
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CHK1 inhibition exacerbates replication stress induced by IGF blockade
We recently reported that genetic or pharmacological inhibition of insulin-like growth factor receptor (IGF-1R) slows DNA replication and induces...
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Differential Angiogenic Induction Impacts Nasal Polyp Tissue Growth
In chronic rhinosinusitis with nasal polyps, inflammatory edema drives tissue remodeling favoring anomalous growth of the nasal mucosa, but a...
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Molecular characterization of an outbreak-involved Bacillus anthracis strain confirms the spillover of anthrax from West Africa
BackgroundAnthrax, a zoonotic disease caused by the spore-forming bacterium Bacillus anthracis , remains a major global public health concern,...
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Histone H4 aggravates inflammatory injury through TLR4 in chlorine gas-induced acute respiratory distress syndrome
BackgroundChlorine gas (Cl 2 ) exposure remains a public health concern in household, occupational, and transportation accidents around the world. The...
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Fibroblast growth factor 10 attenuates chronic obstructive pulmonary disease by protecting against glycocalyx impairment and endothelial apoptosis
BackgroundThe defects and imbalance in lung repair and structural maintenance contribute to the pathogenesis of chronic obstructive pulmonary...
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The toxicity assessment of extract of Peganum harmala L. seeds in Caenorhabditis elegans
BackgroundPeganum harmala L. is a medicinal herb extensively used in traditional Chinese medicine (TCM). So far, relevant reports on the toxicity of P...
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Pathogenic mechanisms of osteogenesis imperfecta, evidence for classification
Osteogenesis imperfecta (OI) is a connective tissue disorder affecting the skeleton and other organs, which has multiple genetic patterns, numerous...
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Hedgehog signaling pathway gene variant influences bronchopulmonary dysplasia in extremely low birth weight infants
BackgroundGenome wide association study identified hedgehog interacting protein gene ( HHIP ) variants with chronic obstructive pulmonary disease and...
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SETD5 modulates homeostasis of hematopoietic stem cells by mediating RNA Polymerase II pausing in cooperation with HCF-1
SETD5 mutations were identified as the genetic causes of neurodevelopmental disorders. While the whole-body knockout of Setd5 in mice leads to...
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Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition
Ataxia telangiectasia mutated and RAD3 related (ATR) protein kinase plays critical roles in ensuring DNA replication, DNA repair, and cell cycle...
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On frailty and accelerated aging during SARS-Cov-2: senescence
The COVID-19 pandemic is a burden for the worldwide healthcare systems. Whereas a clear age-dependent mortality can be observed, especially...
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The SWI/SNF chromatin remodelling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo
Aims/hypothesisStrategies to augment functional beta cell mass include directed differentiation of stem cells towards a beta cell fate, which...
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Oocyte aging: looking beyond chromosome segregation errors
The age‐associated decline in female fertility is largely ascribable to a decrease in oocyte quality. This phenomenon is multifaceted and influenced...
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Dissecting the oncogenic properties of essential RNA-modifying enzymes: a focus on NAT10
Chemical modifications of ribonucleotides significantly alter the physicochemical properties and functions of RNA. Initially perceived as static and...
