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Effect of dapagliflozin on kidney and cardiovascular outcomes by baseline KDIGO risk categories: a post hoc analysis of the DAPA-CKD trial
Aims/hypothesisIn the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) trial, dapagliflozin reduced the risks of...
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Polygenic Risk Scores for Breast Cancer
Purpose of ReviewPolygenic risk scores (PRS) for breast cancer (BC) estimate risk based on the cumulative impact of single-nucleotide polymorphisms....
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Establishment and Validation of a Risk Prediction Model for Non-Invasive Ventilation Failure After Birth in Premature Infants with Gestational Age < 32 Weeks
ObjectivesThis study was performed to construct and validate a risk prediction model for non-invasive ventilation (NIV) failure after birth in...
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Comparison of diagnosis-based risk adjustment methods for episode-based costs to apply in efficiency measurement
BackgroundThe recent rising health spending intrigued efficiency and cost-based performance measures. However, mortality risk adjustment methods are...
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Development of a novel dynamic nosocomial infection risk management method for COVID-19 in outpatient settings
BackgroundApplication of accumulated experience and management measures in the prevention and control of coronavirus disease 2019 (COVID-19) has...
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Association Between the Magnitude of Glycemic Control and Body Weight Loss With GLP-1 Receptor Agonists and Risk of Atherosclerotic Cardiovascular Disease: A Systematic Review and Meta-analyses of Randomized Diabetes Cardiovascular Outcomes Trials
PurposeReduction of major atherosclerotic cardiovascular events (MACE) has not been consistent among different glucagon-like peptide-1 receptor...
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Reduction of sugar, salt and fat content in foods over the period 2016–2021 in Spain: the National Food Reformulation Plan
Background/objectivesPopulation´s dietary intake of saturated fat, sodium, and sugars is higher than the current recommendations in Spain and most...
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Blood volume reduction due to rapid plasma loss after birth in preterm piglets
BackgroundUnderstanding changes in blood volume after preterm birth is critical to preventing cardiovascular deterioration in preterm infants. The...
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Risk for diagnosis or treatment of mood or anxiety disorders in adults after SARS-CoV-2 infection, 2020–2022
COVID-19 is associated with increased risks for mood or anxiety disorders, but it remains uncertain how the association evolves over time or which...
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Predicting cognitive function and dementia risk in patients with hypertension
In spite of the fact that hypertension stand out as the main vascular risk factor for develo** dementia, it is essential to acknowledge the...
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Dapagliflozin reduces thrombin generation and platelet activation: implications for cardiovascular risk reduction in type 2 diabetes mellitus
Aims/hypothesisPeople with diabetes have an increased cardiovascular risk with an accelerated development of atherosclerosis and an elevated...
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Larysuicide: an online risk stratification system to identify patients at high risk of suicide after the laryngeal cancer diagnosis
BackgroundPatients with laryngeal cancer have more than five times the incidence of suicide compared with the general population. In this study, we...
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The Clinical Efficacy and Safety of Bempedoic Acid in Patients at Elevated Risk of Cardiovascular Disease: A Meta-Analysis of Randomized Clinical Trials
PurposeStatins are first-line agents to reduce low-density lipoprotein cholesterol (LDL-C) and cardiovascular risk, however, they are insufficient...
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Low-density lipoprotein cholesterol reduction with immediate combination therapy of statin and ezetimibe compared to statin monotherapy after percutaneous coronary intervention
BackgroundCurrent guidelines recommend a stepwise initiation of lipid-lowering therapy after percutaneous coronary interventions (PCI) in...
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Iron deficiency at birth and risk of hidden hearing loss in infants modification by socioeconomic status: mother-newborn cohort in Shenyang, China
ObjectiveThe diagnosis of hidden hearing loss (HHL) in calm state has not yet been determined, while the nutritional status is not involved in its...
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Effectiveness of prophylactic pharmacological hemostatic agents for reduction of blood loss at vaginal surgery: a systematic review and meta-analysis
Introduction and hypothesisThe objective was to evaluate the effectiveness of pharmacological hemostatic agents in the reduction of blood loss at...
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Risk factor contributions to socioeconomic inequality in cardiovascular risk in the Philippines: a cross-sectional study of nationally representative survey data
BackgroundPrimary prevention of cardiovascular diseases (CVD) increasingly relies on monitoring global CVD risk scores. Lack of evidence on...
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Absolute treatment effects for the primary outcome and all-cause mortality in the cardiovascular outcome trials of new antidiabetic drugs: a meta-analysis of digitalized individual patient data
AimsTreatment effects from the large cardiovascular outcome trials (CVOTs) of new antidiabetic drugs are almost exclusively communicated as hazard...
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The Burden of Cardio-Cerebrovascular Risk Factors: Differences Between Individual Risk and Population Risk
IntroductionCardio-cerebrovascular (CCV) disease contributes significantly to the global burden of disease, with dramatic consequences in terms of...