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Narrative Review of Topiramate: Clinical Uses and Pharmacological Considerations
Due to the diverse mechanisms of action of antiseizure drugs, there has been a rise in prescriptions of these drugs for non-epileptic pathologies....
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Long-term cardiometabolic morbidity in young adults with classic 21-hydroxylase deficiency congenital adrenal hyperplasia
PurposeTo study the current practice for assessing comorbidity in adults with 21-hydroxylase CAH and to assess the prevalence of comorbidity in these...
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Patient-Reported Reasons for Antihypertensive Medication Change: A Quantitative Study Using Social Media
IntroductionHypertension is the leading cause of heart disease in the world, and discontinuation or nonadherence of antihypertensive medication...
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Comprehensive Review and Updates on Holistic Approach Towards Non-Alcoholic Fatty Liver Disease Management with Cardiovascular Disease
Purpose of ReviewThe global prevalence of non-alcoholic fatty liver disease (NAFLD) presents an unmet need in treating these, often asymptomatic,...
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The prevalence of misusing over-the-counter and prescribed drugs in Syrian gymnasiums for performance-enhancing reasons: a cross-sectional study
BackgroundThis study investigates the prevalence of misusing over-the-counter (OTC) and prescribed drugs in Syrian gymnasiums, in addition to types,...
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Comparing and contrasting different herbal products intended for the management of obesity approved in the Palestinian markets
BackgroundThe use of conventional medical therapies has proven to have many setbacks and safety concerns that need further improvement. However,...
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Effectiveness of pre-pregnancy lifestyle in preventing gestational diabetes mellitus—a systematic review and meta-analysis of 257,876 pregnancies
BackgroundGestational Diabetes Mellitus (GDM) is hyperglycaemia first detected during pregnancy. Globally, GDM affects around 1 in 6 live births (up...
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Metabolically Healthy Obesity: Are Interventions Useful?
Purpose of ReviewThis review aims to detail the current global research state of metabolically healthy obesogenesis with regard to metabolic factors,...
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Pharmacotherapy for Obesity—Trends Using a Population Level National Database
BackgroundDespite the growing trend of obesity, the utilization of anti-obesity therapeutic interventions is not robust in the USA. We aimed to...
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Analysis of Anti-Do** Rule Violations That Have Impacted Medal Results at the Summer Olympic Games 1968–2012
IntroductionSince 2004, the International Olympic Committee (IOC) store all samples collected at summer Olympic Games (OG) for retrospective...
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Embracing the Pros and Cons of the New Weight Loss Medications (Semaglutide, Tirzepatide, Etc.)
Purpose of ReviewThe history of multiple weight loss medications has been a concerning paradox based on an increased cardiovascular risk despite...
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The Peripheral Neuropathy Prevalence and Characteristics Are Comparable in People with Obesity and Long-Duration Type 1 Diabetes
IntroductionPeripheral neuropathy is reported in obesity even in the absence of hyperglycaemia.
ObjectiveTo compare the prevalence and characterise...
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Effects of Heterozygous Variants in the Leptin-Melanocortin Pathway on Roux-en-Y Gastric Bypass Outcomes: a 15-Year Case–Control Study
IntroductionHeterozygous variants in the leptin-melanocortin pathway are associated with obesity. However, their effect on the long-term outcomes...
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CLEAR – clozapine in early psychosis: study protocol for a multi-centre, randomised controlled trial of clozapine vs other antipsychotics for young people with treatment resistant schizophrenia in real world settings
BackgroundClozapine is an antipsychotic drug with unique efficacy, and it is the only recommended treatment for treatment-resistant schizophrenia...
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Determination of new psychoactive substances and other drugs in postmortem blood and urine by UHPLC–MS/MS: method validation and analysis of forensic samples
PurposeThis study aimed to validate a modified QuEChERS method followed by ultra-high performance liquid chromatography–tandem mass spectrometry to...
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Obesity in Children with Kidney Disease
Purpose of ReviewWe review the epidemiology, aetiology and consequences of obesity in children with chronic kidney disease (CKD).
Recent Findings ... -
Update on Endoscopic Treatments for Obesity
Purpose of ReviewIncreased morbidity seen with rising obesity rates continues to place an unheralded burden on our health system. Lack of higher...
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Binge-Eating Disorder Interventions: Review, Current Status, and Implications
Purpose of ReviewBinge-eating disorder (BED) is a serious psychiatric problem associated with substantial morbidity that, unfortunately, frequently...