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Clinical implications of exosome-derived noncoding RNAs in liver
Exosomes, one of three main types of extracellular vesicles, are ~30–100 nm in diameter and have a lipid bilayer membrane. They are widely...
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Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review
The myocardial infarction is the main cause of morbidity and mortality in cardiovascular diseases around the world. Although the timely and complete...
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Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges
Extracellular vesicles (EVs), including exosomes, microvesicles, and oncosomes, are nano-sized particles enclosed by a lipid bilayer. EVs are...
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Differential expression of MicroRNAs in Alzheimer’s disease: a systematic review and meta-analysis
Alzheimer’s disease (AD) results in progressive cognitive decline owing to the accumulation of amyloid plaques and hyperphosphorylated tau. MicroRNAs...
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Let-7a, mir-9, mir-132, and mir-218 microRNA Expression in the Dorsomedial and Ventromedial Hypothalamic Nuclei during Aging in Rats
AbstractThe hypothalamus is involved in the regulation of biological rhythms, integration of autonomic, endocrine, and behavioral functions and may...
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Colorectal liver metastasis: molecular mechanism and interventional therapy
Colorectal cancer (CRC) is one of the most frequently occurring malignancy tumors with a high morbidity additionally, CRC patients may develop liver...
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MicroRNA-513c-5p is involved in the pathogenesis of preeclampsia by regulating of low-density lipoprotein receptor-associated protein 6
BackgroundPreeclampsia (PE) is a major cause of maternal and perinatal morbidity and mortality. Studies on the role of microRNAs (miRNAs), in the...
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Knockdown of lncRNA LINC00662 suppresses malignant behaviour of osteosarcoma cells via competition with miR-30b-3p to regulate ELK1 expression
PurposeOsteosarcoma is a type of bone malignancy that mainly occurred in teenagers. This investigation is aimed to clarify the effect of long...
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Natural products: potential drugs for the treatment of renal fibrosis
With the increasing prevalence and mortality, chronic kidney disease (CKD) has become a world public health problem. As the primary pathological...
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The Role of Extracellular Non-coding RNAs in Atherosclerosis
Atherosclerosis (AS) is a complex chronic inflammatory disease that leads to myocardial infarction, stroke, and disabling peripheral artery disease....
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An overview of current development and barriers on liquid biopsy in patients with early-stage non-small-cell Lung cancer
PurposeLiquid biopsy is a promising technological method in patient management of early-stage non-small-cell lung cancer (NSCLC). The detection...
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A systematic review of miRNAs as biomarkers in osteoporosis disease
BackgroundOsteoporosis is often considered to be a disease of the elderly, which is characterized by two characteristics: low bone mineral density...
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A meta-analysis of microRNA expression profiling studies in heart failure
Heart failure (HF) is a major consequence of many cardiovascular diseases with high rate of morbidity and mortality. Early diagnosis and prevention...
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Study of association between different microRNA variants and the risk of idiopathic recurrent pregnancy loss
AimRecurrent pregnancy loss (RPL) is a common reproductive disorder among women and a major cause of infertility among them; however, the underlying...
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Extracellular vesicles as tools and targets in therapy for diseases
Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the extracellular space. They exhibit diverse sizes, contents, and...
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Comprehensive Analysis of Key mRNAs and lncRNAs in Osteosarcoma Response to Preoperative Chemotherapy with Prognostic Values
ObjectiveOsteosarcoma is one of the most common types of bone sarcoma with a poor prognosis. However, identifying the predictive factors that...
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Differential miRNA Expression in Osteoporotic Elderly Patients with Hip Fractures Compared to Young Patients
BackgroundThe expression pattern of micro-RNAs (miRNA) has been implicated in the pathomechanism of various bone disorders, and has a role in...
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The usefulness of microRNA in urine and saliva as a biomarker of gastroenterological cancer
MicroRNA (miR) is a type of short non-coding RNA comprising 21–25 nucleotides. While it has been researched widely, its relationship with cancer was...
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Mesenchymal Stromal Cell Exosomes in Cardiac Repair
Purpose of the ReviewMesenchymal stromal cells (MSCs) are considered an attractive option for cell-based therapy because of their immune-privileged...
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Identification of hsa-miR-106a-5p as an impact agent on promotion of multiple sclerosis using multi-step data analysis
Multiple sclerosis (MS) is a chronic, demyelinating disease in which the neuron myelin sheath is disrupted and leading to signal transductions...
