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Clinical implications and genetical insights of SOX6 expression in acute myeloid leukemia
BackgroundTranscription factor SOX6 belongs to Sry‐related high‐mobility‐group box (SOX) family, has been reported to be downregulated and acts as a...
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Involvement of KCa3.1 channel activity in immediate perioperative cognitive and neuroinflammatory outcomes
BackgroundPotassium channels (KCa3.1; Kv1.3; Kir2.1) are necessary for microglial activation, a pivotal requirement for the development of...
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Effect of thyroid function on pre-β1 high-density lipoprotein levels in patients with Graves’ disease undergoing radioiodine treatment
ContextThe metabolism of HDL is altered in thyroid dysfunctions. Preβ-1 HDL is a very small discoidal precursor HDL and promotes cholesterol efflux...
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HMGB1 promotes Ox-LDL-induced endothelial cell damage by inhibiting PI3K/Akt signaling pathway
BackgroundAtherosclerosis is the pathological basis of cardio-cerebrovascular diseases. Oxidized low-density lipoprotein (ox-LDL) is an important...
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Identification of HMGB2 associated with proliferation, invasion and prognosis in lung adenocarcinoma via weighted gene co-expression network analysis
BackgroundHigh mobility group protein B2 (HMGB2) is a multifunctional protein that plays various roles in different cellular compartments. Moreover,...
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Examining interrater agreement between self-report and proxy-report responses for the quality of life-aged care consumers (QOL-ACC) instrument
BackgroundQuality of life is an important quality indicator for health and aged care sectors. However, self-reporting of quality of life is not...
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Role of LsrR in the regulation of biofilm formation in mammary pathogenic Escherichia coli
BackgroundMammary Pathogenic Escherichia coli (MPEC) is an important pathogen that can escape the attack of the host immune system through biofilm...
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Virtual pulmonary rehabilitation approaches in patients with post COVID syndrome: a pilot study
BackgroundThe characteristics of optimal virtual pulmonary rehabilitation (PR) for individuals with post-COVID syndrome (PCS) have not been...
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HMGB1 neuroimmune signaling and REST-G9a gene repression contribute to ethanol-induced reversible suppression of the cholinergic neuron phenotype
Adolescent binge drinking increases Toll-like receptor 4 (TLR4), receptor for advanced glycation end products (RAGE), the endogenous TLR4/RAGE...
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Shuxuening Injection Inhibits Apoptosis and Reduces Myocardial Ischemia-Reperfusion Injury in Rats through PI3K/AKT Pathway
ObjectiveTo investigate the main components and potential mechanism of Shuxuening Injection (SXNI) in the treatment of myocardial...
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Clarithromycin prevents preterm birth and neonatal mortality by dampening alarmin-induced maternal–fetal inflammation in mice
BackgroundOne of every four preterm neonates is born to a woman with sterile intra-amniotic inflammation (inflammatory process induced by alarmins);...
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CircRTN1 stimulates HMGB1 to regulate the malignant progression of papillary thyroid cancer by sponging miR-101-3p
BackgroundThe important role played by circular RNA (circRNA) in promoting the progression of papillary thyroid cancer (PTC) is attracting ever more...
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Yolk sac tumor and dysgerminoma in the left gonad following gonadoblastoma in the right gonad in a 46,XY DSD with a novel SRY missense mutation: a case report
BackgroundApproximately 10–15% of 46,XY disorders of sex development (DSDs) have an SRY mutation residing in the high mobility group (HMG) domain....
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Physical function and activity, pain, and health status in adults with myelomeningocele after orthotic management from childhood: a descriptive study
BackgroundIndividuals with myelomeningocele (MMC) exhibit neurological deficits below the lesion level involving both motor and sensory functions....
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Predictive value of chemokines (CCL 2) in bronchoalveolar lavage fluid for refractory mycoplasma pneumonia in children
BackgroundThere are relatively few studies investigating C-C motif chemokine ligand 2 (CCL2) level in bronchoalveolar lavage fluid (BALF) in children...
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Fibroblast-like synoviocytes-derived exosomal circFTO deteriorates rheumatoid arthritis by enhancing N6-methyladenosine modification of SOX9 in chondrocytes
BackgroundRheumatoid arthritis (RA) is a chronic inflammatory disease that causes disability worldwide. Exosomes released by fibroblast-like...
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Exploring the effects of fitbit incentive on treatment outcomes in veterans undergoing intensive pain rehabilitation program
ObjectiveThis study compares clinical pain outcomes between patients in a pain treatment program that received a Fitbit, to patients that did not. We...
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HMGB1 in the mPFC governs comorbid anxiety in neuropathic pain
BackgroundWhether neuroinflammation causes comorbid mood disorders in neuropathic pain remains elusive. Here we investigated the role of high...
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Use of an antagonist of HMGB1 in mice affected by malignant mesothelioma: a preliminary ultrasound and optical imaging study
BackgroundMalignant mesothelioma (MM) is an aggressive tumor, with a poor prognosis, usually unresectable due to late diagnosis, mainly treated with...
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Development of a biomarker panel for assessing cardiovascular risk in diabetic patients with chronic limb-threatening ischemia (CLTI): a prospective study
BackgroundLower-extremity endovascular revascularization (LER) is often required for diabetic patients with chronic limb threatening ischemia (CLTI)....
