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Givinostat: First Approval
Givinostat (DUVYZAT™), an orally available histone deacetylase inhibitor, is being developed by Italfarmaco for the treatment of muscular dystrophy...
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Clonogenic assays improve determination of variant allele frequency of driver mutations in myeloproliferative neoplasms
Molecular diagnostics moves more into focus as technology advances. In patients with myeloproliferative neoplasms (MPN), identification and...
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EBF1–JAK2 inhibits the PAX5 function through physical interaction with PAX5 and kinase activity
Gene aberrations of B-cell regulators and growth signal components such as the JAK–STAT pathway are frequently found in B-cell acute lymphoblastic...
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A case of JAK2V617F-positive essential thrombocythemia where allele burden was reduced by a PD-1 inhibitor
The Janus kinase/signal transducers and activators of transcription signaling pathway induces programmed death ligand-1 (PD-L1) expression. JAK2...
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Chronic myeloid leukemia (CML) evolves from Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) with unexpected frequency
Myeloproliferative neoplasms (MPN) are chronic clonal disorders characterized by overproduction of myeloid-lineage blood cells and potential risk of...
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Combined venous and arterial thrombosis revealing underlying myeloproliferative disorder in a young patient: a case report
BackgroundMyeloproliferative neoplasms (MPNs) such as polycythemia Vera (PV) and Essential Thrombocythemia (ET) can be associated with a high risk of...
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Inferior Survival Among Polycythemia Vera Patients Exhibiting Body Mass Index Reduction
The prognostic significance and the predictive factors for weight loss are not entirely elucidated for Polycythemia Vera (PV). In this single-center...
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The genetic risk factors for cerebral venous thrombosis: a case-control study in a Chinese national comprehensive hospital
BackgroundAbout 13–25% of cerebral venous thrombosis (CVT) cases lack clear etiology, which may be associated with underlying genetic factors. This...
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Portal vein thrombosis due to essential thrombocythemia with limited cutaneous systemic sclerosis
Portal vein thrombosis is caused by various diseases, including liver cirrhosis, cancer, abdominal infection, and myeloproliferative disorders....
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Portal Vein Thrombosis in Adults without Cirrhosis
Purpose of ReviewThe management of non-cirrhotic, non-tumoral portal vein thrombosis (PVT) has historically been challenging due to a paucity of...
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A comparison of qPCR and ddPCR used for quantification of the JAK2 V617F allele burden in Ph negative MPNs
Philadelphia-negative myeloproliferative neoplasms (MPNs) are a diverse group of diseases whose common feature is the presence of V617F mutation of...
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Gaucher disease in a patient with membranoproliferative glomerulonephritis: case report
BackgroundGaucher disease (GD) is a rare autosomal recessive inherited, lysosomal storage disoder that involves liver, spleen, lung, bone, bone...
