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Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies?
The use of autopsies in medicine has been declining. The COVID-19 pandemic has documented and rejuvenated the importance of autopsies as a tool of...
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Bone marrow embolism: should it result from traumatic bone lesions? A histopathological human autopsy study
Bone marrow embolism (BME) is likely a consequence of fractures in which pulmonary vessels are the most affected. However, some cases of BME were...
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Elevated level of serum human epididymis protein 4 (HE4) predicts disease severity and mortality in COVID-19 pneumonia
BackgroundWe retrospectively analyzed serum level of human epididymis protein 4 (HE4) as a pulmonary inflammatory biomarker in patients with COVID-19...
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Post COVID-19 pneumo-hematocele: clinical presentation and treatment pathway
ObjectivesThe appearance of characteristic pulmonary lesions has been noted after COVID-19, being described as post-COVID-19 pneumo-hematocele. The...
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Feasibility and safety of ultrasound-guided minimally invasive autopsy in COVID-19 patients
ObjectivesTo determine the feasibility and safety of ultrasound-guided minimally invasive autopsy in COVID-19 patients.
Methods60 patients who...
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The Potential Protective Role of GS-441524, a Metabolite of the Prodrug Remdesivir, in Vaccine Breakthrough SARS-CoV-2 Infections
Cases of vaccine breakthrough, especially in variants of concern (VOCs) infections, are emerging in coronavirus disease (COVID-19). Due to mutations...
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Mesenchymal stem cell therapy for severe COVID-19
The coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has placed a global public burden on...
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Neuropathological lesions in intravenous BCG-stimulated K18-hACE2 mice challenged with SARS-CoV-2
In the wake of the COVID-19 pandemic caused by SARS-CoV-2, questions emerged about the potential effects of Bacillus Calmette-Guérin (BCG) vaccine on...
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COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City
SARS-CoV-2, the etiologic agent of COVID-19, is a global pandemic with substantial mortality dominated by acute respiratory distress syndrome. We...
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A potent neutralizing antibody provides protection against SARS-CoV-2 Omicron and Delta variants via nasal delivery
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still rapidly spreading worldwide. Many drugs and vaccines have been approved for...
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Childhood interstitial lung disease more prevalent in infancy: a practical review
Childhood interstitial lung disease (chILD) is a heterogeneous group of uncommon, mostly chronic pediatric pulmonary disorders characterized by...
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Acute exacerbation of interstitial lung disease associated with rheumatic disease
Interstitial lung disease (ILD) is a cause of morbidity and mortality in patients with rheumatic diseases, such as connective-tissue diseases,...
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Autopsy findings in COVID-19-related deaths: a literature review
Although many clinical reports have been published, little is known about the pathological post-mortem findings from people who have died of the...
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Proposal of selective wedge instillation of pulmonary surfactant for COVID-19 pneumonia based on computational fluid dynamics simulation
BackgroundThe most important target cell of SARS-CoV-2 is Type II pneumocyte which produces and secretes pulmonary surfactant (PS) that prevents...
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COVID-19: biologic and immunosuppressive therapy in gastroenterology and hepatology
The coronavirus disease 2019 (COVID-19) pandemic is an ongoing global health crisis causing major challenges for clinical care in patients with...
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Proposed Pathogenesis of Diffuse Alveolar Hemorrhage in Idiopathic Pulmonary Hemosiderosis
Idiopathic pulmonary hemosiderosis (IPH) is a rare disease that causes diffuse alveolar hemorrhage (DAH). The latest data suggests an immunologic...
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Histiocytic hyperplasia with hemophagocytosis and acute alveolar damage in COVID-19 infection
The spectrum of COVID-19 infection includes acute respiratory distress syndrome (ARDS) and macrophage activation syndrome (MAS), although the...
