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Ferroptosis Inducers in Thyroid Cancer
PurposePapillary thyroid carcinoma (PTC) progression imparts reduced patient survival. Tumor resistance and progression can be influenced by...
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Prevention and treatment of osteoporosis with natural products: Regulatory mechanism based on cell ferroptosis
ContextWith the development of society, the number of patients with osteoporosis is increasing. The prevention and control of osteoporosis has become...
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Obstructive sleep apnea affects cognition: dual effects of intermittent hypoxia on neurons
Obstructive sleep apnea (OSA) is a common respiratory disorder. Multiple organs, especially the central nervous system (CNS), are damaged, and...
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Hepcidin: a New Serial Biomarker for Iron Deficiency Anemia in Bariatric Surgery
Iron deficiency anemia (IDA) is one of the most common nutritional problems in patients with obesity and after bariatric surgery. While it can be...
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Hypoxia-induced signaling in the cardiovascular system: pathogenesis and therapeutic targets
Hypoxia, characterized by reduced oxygen concentration, is a significant stressor that affects the survival of aerobic species and plays a prominent...
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MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis
Septic cardiomyopathy is one of the most severe and common complications in patients with sepsis and poses a great threat to their prognosis....
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Novel Insights into Osteoclast Energy Metabolism
Purpose of ReviewOsteoclasts are crucial for the dynamic remodeling of bone as they resorb old and damaged bone, making space for new bone. Metabolic...
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Iron replacement therapy in heart failure: a literature review
BackgroundHeart failure (HF) is a major global challenge, emphasised by its designation as the leading cause of hospitalisation in those aged 65 and...
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Ferroptosis is an effective strategy for cancer therapy
Ferroptosis is a form of intracellular iron-dependent cell death that differs from necrosis, autophagy and apoptosis. Intracellular iron mediates...
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Nutritional immunity: the impact of metals on lung immune cells and the airway microbiome during chronic respiratory disease
Nutritional immunity is the sequestration of bioavailable trace metals such as iron, zinc and copper by the host to limit pathogenicity by invading...
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Steroidal saponin SSPH I induces ferroptosis in HepG2 cells via regulating iron metabolism
Hepatocellular carcinoma (HCC) is a common type of solid liver carcinoma. Regulating ferroptosis is important for the treatment of HCC. SSPH I is an...
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Si-Wu-Tang alleviates metabolic dysfunction-associated fatty liver disease by inhibiting ACSL4-mediated arachidonic acid metabolism and ferroptosis in MCD diet-fed mice
BackgroundMetabolic dysfunction-associated fatty liver disease (MAFLD) is a prevalent chronic liver disease worldwide. Si-Wu-Tang (SWT), a...
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Ferroptosis: an iron-dependent cell death form linking metabolism, diseases, immune cell and targeted therapy
Compared with the traditional forms of cell death—apoptosis, necrosis and autophagy, ferroptosis is a novel form of iron-dependent programmed cell...
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The effect of red blood cell disorders on male fertility and reproductive health
Male infertility is defined as a failure to conceive after 12 months of unprotected intercourse owing to suspected male reproductive factors....
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Repurposing approved non-oncology drugs for cancer therapy: a comprehensive review of mechanisms, efficacy, and clinical prospects
Cancer poses a significant global health challenge, with predictions of increasing prevalence in the coming years due to limited prevention, late...
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Engineered antibodies: new possibilities for brain PET?
Almost 50 million people worldwide are affected by Alzheimer’s disease (AD), the most common neurodegenerative disorder. Development of...
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Role of iron homeostasis in the heart
As an essential trace mineral in mammals and the second most abundant metal in the Earth’s crust, iron acts as a double-edged sword in humans. Iron...
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Osthole inhibits malignant phenotypes and induces ferroptosis in KRAS-mutant colorectal cancer cells via suppressing AMPK/Akt signaling
PurposeFerroptosis is a form of cell death driven by iron-dependent lipid peroxidation. Intriguingly, KRAS-mutant cancers are particularly vulnerable...
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Iron overload in the HCT patient: a review
Iron overload (IO) is common in hematologic malignancies and hemoglobinopathies, largely due to red cell transfusion burden. End-organ damage from IO...
