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Mitochondrial Quality Control in Ovarian Function: From Mechanisms to Therapeutic Strategies
Mitochondrial quality control plays a critical role in cytogenetic development by regulating various cell-death pathways and modulating the release...
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Long non-coding RNAs in cardiac hypertrophy and heart failure: functions, mechanisms and clinical prospects
The surge in reports describing non-coding RNAs (ncRNAs) has focused attention on their possible biological roles and effects on development and...
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Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces severe neural injuries, and is one of the leading causes...
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Exercise and chronic kidney disease: potential mechanisms underlying the physiological benefits
Increasing evidence indicates that exercise has beneficial effects on chronic inflammation, cardiorespiratory function, muscle and bone strength and...
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Signaling pathways in cancer metabolism: mechanisms and therapeutic targets
A wide spectrum of metabolites (mainly, the three major nutrients and their derivatives) can be sensed by specific sensors, then trigger a series of...
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Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
The ageing process is a systemic decline from cellular dysfunction to organ degeneration, with more predisposition to deteriorated disorders....
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Adverse effects of acute tubular injury on the glomerulus: contributing factors and mechanisms
The intricate relationship between tubular injury and glomerular dysfunction in kidney diseases has been a subject of extensive research. While the...
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Clinical and therapeutic implications of cavernous sinus invasion in pituitary adenomas
Invasion of the cavernous sinus by pituitary adenomas impedes complete surgical resection, compromises biochemical remission, and increases the risk...
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Activation of senescence in critically ill patients: mechanisms, consequences and therapeutic opportunities
Whereas aging is a whole-organism process, senescence is a cell mechanism that can be triggered by several stimuli. There is increasing evidence that...
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Mechanisms and clinical management of eosinophilic oesophagitis: an overview
Since the first description of eosinophilic oesophagitis (EoE) less than three decades ago, we have observed a striking increase in the number of...
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Adrenal insufficiency in liver diseases - pathophysiology and underlying mechanisms
Relative adrenal insufficiency (RAI) is common in critically ill patients with cirrhosis, but it has been also documented in non-critically ill...
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A new marker constructed from immune-related lncRNA pairs can be used to predict clinical treatment effects and prognosis: in-depth exploration of underlying mechanisms in HNSCC
BackgroundLong non-coding RNA (lncRNA) plays a vital role in tumor proliferation, migration, and treatment. Since it is challenging to standardize...
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Moving beyond cisplatin resistance: mechanisms, challenges, and prospects for overcoming recurrence in clinical cancer therapy
Cisplatin, a classical platinum-based chemotherapy agent, has been a frontline treatment for various cancers for decades. However, its effectiveness...
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Effects and mechanisms of acupuncture on women related health
Globally, public health interventions have resulted in a 30-year increase in women’s life expectancy. However, women’s health has not increased when...
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The role of LncRNA LBX2-AS1 in cancers: functions, mechanisms and potential clinical utility
Increasingly advanced biology technique has revealed that long non-coding RNAs (lncRNA) as critical factors that exert significant regulatory effects...
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Therapeutic Effects of Shenfu Injection in Shock
Shock is the clinical manifestation of acute circulatory failure, which results in inadequate utilization of cellular oxygen. It is a common...
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Chinese Herbal Medicines for Coronary Heart Disease: Clinical Evidence, Pharmacological Mechanisms, and the Interaction with Gut Microbiota
Coronary heart disease (CHD) is a common type of cardiovascular disease (CVD) that has been on the rise in terms of both incidence and mortality...
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Molecular Mechanisms Underlying Systemic Sclerosis–Associated Interstitial Lung Disease and Idiopathic Pulmonary Fibrosis: an Update
Purpose of reviewSystemic sclerosis–associated interstitial lung disease (SSc-ILD) and idiopathic pulmonary fibrosis (IPF) are fatal fibrotic lung...
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Comparison of therapeutic effects of N-Acetylcysteine with pregabalin in improving the clinical symptoms of painful diabetic neuropathy: a randomized, double-blind clinical trial
ObjectivesPainful diabetic neuropathy (PDN) is highly prevalent and annoyingly in patients with diabetes. The aim of this study was to investigate...
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The mechanism underlying extrapulmonary complications of the coronavirus disease 2019 and its therapeutic implication
The coronavirus disease 2019 (COVID-19) is a highly transmissible disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...
