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Clopidogrel-induced neutropenia in an 80-year-old patient with chronic kidney disease who underwent percutaneous coronary intervention: a case report and literature review
BackgroundClopidogrel is a widely-used antiplatelet and acts as an adenosine diphosphate receptor inhibitor. Neutropenia is a rare but serious...
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Advanced statistics identification of participant and treatment predictors associated with severe adverse effects induced by fluoropyrimidine-based chemotherapy
PurposeAdverse effects following fluoropyrimidine-based chemotherapy regimens are common. However, there are no current accepted diagnostic markers...
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The Pitfalls of Abnormal Laboratory Value Interpretation in Vaccine Clinical Trials: The Example of Asymptomatic Transient Neutropenia
Hematological and clinical chemistry measurements are an integral part of vaccine safety monitoring. While adopting a conservative approach is...
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Current methods of preventing infectious disease and managing febrile neutropenia in childhood cancer patients: a nationwide survey in Japan
BackgroundPreventing infection and managing febrile neutropenia (FN) is mandatory for children with cancer undergoing chemotherapy. However, the...
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Pegfilgrastim for primary prophylaxis of febrile neutropenia in multiple myeloma
Multiple myeloma (MM) survival rates have been substantially increased thanks to novel agents that have improved survival outcomes and shown better...
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Effect of early granulocyte-colony-stimulating factor administration in the prevention of febrile neutropenia and impact on toxicity and efficacy of anti-CD19 CAR-T in patients with relapsed/refractory B-cell lymphoma
Chimeric Antigen Receptor T cells (CAR-T) are an outbreaking treatment option for relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL)....
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Use of cefepime, meropenem, or piperacillin/tazobactam as initial treatment for febrile neutropenia in patients with hematological malignancy — a real-life experience
BackgroundAntimicrobials like fourth-generation cephalosporins, carbapenems, or β-lactams are widely used in treatment of febrile neutropenia (FN)....
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Severe infections requiring intensive care unit admission in patients receiving ibrutinib for hematological malignancies: a groupe de recherche respiratoire en réanimation onco-hématologique (GRRR-OH) study
BackgroundIn the last decade, Ibrutinib has become the standard of care in the treatment of several lymphoproliferative diseases such as chronic...
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Severe acute respiratory syndrome coronavirus-2 Alpha variant (B.1.1.7), original wild-type severe acute respiratory syndrome coronavirus 2, and cytomegalovirus co-infection in a young adult with acute lymphoblastic leukemia, case report, and review of the possible cytomegalovirus reactivation mechanisms
BackgroundLike other viral infections, severe acute respiratory syndrome coronavirus-2 infection could affect different human body systems, including...
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Ruxolitinib plus standard of care in severe hospitalized adults with severe fever with thrombocytopenia syndrome (SFTS): an exploratory, single-arm trial
BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease, and its morbidity and mortality are...
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Paliperidone induced neutropenia in first episode psychosis: a case report
BackgroundNeutropenia, a decrease in total number of neutrophils below 1500/mm 3 and particularly severe neutropenia, defined as neutrophils less...
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Long-term outcomes with rituximab as add-on therapy in severe childhood-onset lupus nephritis
BackgroundLong-term data pertaining to rituximab as add-on therapy in childhood-onset lupus nephritis (cLN) is scarce.
MethodsA retrospective cohort...
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Clinical Characteristics and Management of Febrile Neutropenia among Pediatric Cancer Patients Admitted at Tertiary Hospital in Dar es Salaam
Febrile neutropenia (FN) in cancer pediatric patients is a serious fatal condition complicating cancer treatment which results to increased morbidity...
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Genetic variations in the ATP-binding cassette transporter ABCC10 are associated with neutropenia in Japanese patients with lung cancer treated with nanoparticle albumin-bound paclitaxel
ABCC10/MRP7, an ATP-binding cassette (ABC) transporter, has been implicated in the extracellular transport of taxanes. Our group reported that the ABCC10...
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GSTP1 c.313A > G mutation is an independent risk factor for neutropenia hematotoxicity induced by anthracycline-/paclitaxel-based chemotherapy in breast cancer patients
BackgroundThe link between glutathione S-transferase P1 (GSTP1) c.313A > G polymorphism and chemotherapy-related adverse events remains...
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Evaluating the indotecan–neutropenia relationship in patients with solid tumors by population pharmacokinetic modeling and sigmoidal Emax regressions
PurposeThis study aimed at characterizing indotecan population pharmacokinetics and explore the indotecan–neutropenia relationship in patients with...
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Serum caspase-cleaved cytokeratin-18 fragment as a prognostic biomarker in hematological patients with febrile neutropenia
The study aim was to determine the benefit of the measurement of serum caspase-cleaved cytokeratin-18 (CK-18) fragment as a prognostic marker of...
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Evaluating the safety and effectiveness of PegaGen® (pegfilgrastim) for the prevention of chemotherapy-induced febrile neutropenia: a post-marketing surveillance study
PurposePhase IV clinical trials are required to evaluate the real-world safety and effectiveness of drugs. This study aimed to evaluate the safety...
