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High-risk pituitary adenomas and strategies for predicting response to treatment
High-risk pituitary adenomas are aggressive. They show clinical and imaging features similar to those of carcinomas, including infiltration of the...
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Epithelioid inflammatory myofibroblastic sarcoma with VCL–ALK fusion of central nervous system: case report and brief review of the literature
Epithelioid inflammatory myofibroblastic sarcomas are an aggressive variant of inflammatory myofibroblastic tumor described primarily in the abdomen...
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Spezielle mesenchymale Tumoren der Kopf-Hals-Region: Neues aus der WHO 2022
Similar to the approach adopted in the classification of tumors in other organs, a new feature of the current Word Health Organization (WHO)...
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Recent advances and conceptual changes in the classification of neuroendocrine tumors of the thymus
Neuroendocrine tumors of the thymus (TNET) are exceedingly rare neoplasms. Their histomorphology is identical to neuroendocrine tumors elsewhere in...
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Patient derived tumoroids of high grade neuroendocrine neoplasms for more personalized therapies
There are no therapeutic predictive biomarkers or representative preclinical models for high-grade gastroenteropancreatic neuroendocrine neoplasms...
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Study on intracranial meningioma using PET ligand investigation during follow-up over years (SIMPLIFY)
PurposeRadiologic follow-up of patients with a meningioma at the skull base or near the venous sinuses with magnetic resonance imaging (MRI) after...
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Correlation of somatostatin receptor PET/CT imaging features and immunohistochemistry in neuroendocrine tumors of the lung: a retrospective observational study
PurposeTo correlate somatostatin receptor (SSTR) and proliferative activity profile (SSTR2, SSTR5, Ki-67) at immunohistochemistry (IHC) with...
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Diagnostic performance of 68Ga-DOTATOC PET/CT in tumor-induced osteomalacia
ObjectiveTumor-induced osteomalacia (TIO) is caused by typically small tumors that secrete fibroblast growth factor 23 (FGF23). As tumor resection is...
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Clear cell meningiomas are defined by a highly distinct DNA methylation profile and mutations in SMARCE1
Clear cell meningioma represents an uncommon variant of meningioma that typically affects children and young adults. Although an enrichment of...
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SSTR2 Expression in Olfactory Neuroblastoma: Clinical and Therapeutic Implications
Somatostatin receptor 2 (SSTR2) expression has previously been documented in olfactory neuroblastoma (ONB). Here, we fully characterize SSTR2...
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Growth hormone increase by luteinizing hormone-releasing hormone reflects gonadotroph-related characteristics in acromegaly
PurposeWe previously showed the clinical characteristics of acromegaly with a paradoxical growth hormone (GH) response to oral glucose or...
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Recurrence in acromegaly: two tertiary centers experience and review of the literature
BackgroundRecurrence of acromegaly after successful surgery is a rare event, but no clear data are reported in the literature about its recurrence...
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Gene fusions are frequent in ACTH-secreting neuroendocrine neoplasms of the pancreas, but not in their non-pancreatic counterparts
Ectopic Cushing syndrome is a rare clinical disorder resulting from excessive adrenocorticotrophic hormone (ACTH) produced by non-pituitary...
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Histopathologische Diagnostik von soliden und zystischen Pankreasläsionen mit Hauptaugenmerk auf dem duktalen Adenokarzinom
Pancreas pathology is constantly evolving and can present various challenges for pathologists. This paper is focused on providing helpful hints for...
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Phosphaturic mesenchymal tumor: management and outcomes of ten patients treated at a single institution
BackgroundPhosphaturic mesenchymal tumor (PMT) is a rare tumor that causes tumor-induced osteomalacia. Patients present with non-specific symptoms...
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Malignant gastrointestinal neuroectodermal tumor in head and neck: two challenging cases with diverse morphology and different considerations for differential diagnosis
Malignant gastrointestinal neuroectodermal tumor (MGNET) is a sarcoma typically involving the gastrointestinal tract with neuroectodermal...
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Evidence of a common cell origin in a case of pancreatic mixed intraductal papillary mucinous neoplasm–neuroendocrine tumor
Recently, the term mixed neuroendocrine non-neuroendocrine neoplasms (MiNEN) has been proposed as an umbrella definition covering different possible...
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Update on Histological Reporting Changes in Neuroendocrine Neoplasms
Purpose of ReviewClassification and nomenclature of neuroendocrine neoplasms (NEN) have frequently changed over the last years. These changes reflect...