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1. Wilms tumour

   Wilms tumour (WT) is a childhood embryonal tumour that is paradigmatic of the intersection between disrupted organogenesis and tumorigenesis. Many WT...

   Filippo Spreafico, Conrad V. Fernandez, ... Kathy Pritchard-Jones in Nature Reviews Disease Primers

   Article 14 October 2021
   

2. Isolated cryptococcal osteomyelitis of the sacrum in an immunocompetent patient: a case report and literature review

   Background

   Cryptococcus neoformans , an opportunistic fungal pathogen, seldom causes infection in immunocompetent people. Cryptococcal osteomyelitis...

   Yanchun Zhong, Yuxi Huang, ... Yongjun Ye in BMC Infectious Diseases

   Article Open access 24 February 2023
   

3. [²²⁵Ac]Ac- and [¹¹¹In]In-DOTA-trastuzumab theranostic pair: cellular dosimetry and cytotoxicity in vitro and tumour and normal tissue uptake in vivo in NRG mice with HER2-positive human breast cancer xenografts

   Background

   Trastuzumab (Herceptin) has improved the outcome for patients with HER2-positive breast cancer (BC) but brain metastases (BM) remain a...

   Misaki Kondo, Zhongli Cai, ... Raymond M. Reilly in EJNMMI Radiopharmacy and Chemistry

   Article Open access 26 September 2023
   

4. Assessing circulating tumour DNA (ctDNA) as a prognostic biomarker in locally advanced rectal cancer: a systematic review and meta-analysis

   Introduction

   Circulating tumour DNA (ctDNA) has emerged as a promising biomarker in various cancer types, including locally advanced rectal cancer...

   Niall J. O’Sullivan, Hugo C. Temperley, ... Michael E. Kelly in International Journal of Colorectal Disease

   Article Open access 29 May 2024
   

5. Surgical outcome of isolated benign peripheral nerve sheath tumors without neurofibromatosis

   Background

   Benign peripheral nerve sheath tumors (BPNSTs) include schwannomas and neurofibromas. About 10% of soft tissue sarcomas are malignant...

   Mohammud Ahmud Salim, Hossam Elnoamany, ... Ahmed Said Mansour in Egyptian Journal of Neurosurgery

   Article Open access 28 May 2024
   

6. Single-cell profiling of tumour evolution in multiple myeloma — opportunities for precision medicine

   Multiple myeloma (MM) is a haematological malignancy of plasma cells characterized by substantial intraclonal genetic heterogeneity. Although...

   Ankit K. Dutta, Jean-Baptiste Alberge, ... Irene M. Ghobrial in Nature Reviews Clinical Oncology

   Article 11 January 2022
   

7. Parvimonas micra is associated with tumour immune profiles in molecular subtypes of colorectal cancer

   The importance of the tumour microbiome in different aspects of colorectal cancer (CRC) has been increasingly recognised, but many questions remain....

   Thyra Löwenmark, **ngru Li, ... Richard Palmqvist in Cancer Immunology, Immunotherapy

   Article Open access 17 March 2022
   

8. Effect of Gemcitabine based chemotherapy on the immunogenicity of pancreatic tumour cells and T-cells

   Purpose

   Chemotherapy for advanced pancreatic cancer has limited efficacy due to the difficultly of treating established tumours and the evolution of...

   P. L. Smith, Y. Yogaratnam, ... A. G. Dalgleish in Clinical and Translational Oncology

   Article Open access 13 July 2020
   

9. Compromised activity of natural killer cells in diffuse large b-cell lymphoma is related to lymphoma-induced modification of their surface receptor expression

   While natural killer (NK) cells are essential players in detection and elimination of malignant cells, these surveillance properties can be...

   Tehila Azoulay, Ilana Slouzky, ... Shimrit Ringelstein-Harlev in Cancer Immunology, Immunotherapy

   Article 01 September 2022
   

10. Tissue-resident memory T cells in the urogenital tract

    Our understanding of T cell memory responses changed drastically with the discovery that specialized T cell memory populations reside within...

    Loreto Parga-Vidal, Michiel C. van Aalderen, ... Klaas P. J. M. van Gisbergen in Nature Reviews Nephrology

    Article 25 January 2022
    

11. A first-in-human study of [⁶⁸Ga]Ga-CDI: a positron emitting radiopharmaceutical for imaging tumour cell death

    Purpose

    This study assesses human biodistribution, radiation dosimetry, safety and tumour uptake of cell death indicator labelled with ⁶⁸ Ga ([ ⁶⁸ Ga]Ga-...

    Ivan Ho Shon, Thomas Hennessy, ... Philip J. Hogg in European Journal of Nuclear Medicine and Molecular Imaging

    Article Open access 02 July 2022
    

12. Isolated Frontal Sinus Undifferentiated Carcinoma: First case Report in the Literature

    Sinonasal undifferentiated carcinoma (SNUC) is a rare tumor which is aggressive in nature, has a different clinical course in contrast to sinonasal...

    Rajkumar Jain, Deepak Saharan, ... Varchasvi Meena in Indian Journal of Otolaryngology and Head & Neck Surgery

    Article 26 August 2023
    

13. Intratumoural administration and tumour tissue targeting of cancer immunotherapies

    Immune-checkpoint inhibitors and chimeric antigen receptor (CAR) T cells are revolutionizing oncology and haematology practice. With these and other...

    Ignacio Melero, Eduardo Castanon, ... Aurelien Marabelle in Nature Reviews Clinical Oncology

    Article 18 May 2021
    

14. Pituitary stem cells: past, present and future perspectives

    Pituitary cells that express the transcription factor SOX2 are stem cells because they can self-renew and differentiate into multiple pituitary...

    María Inés Pérez Millán, Leonard Y. M. Cheung, ... Sally A. Camper in Nature Reviews Endocrinology

    Article 15 December 2023
    

15. Characteristics of premanufacture CD8⁺ T cells determine CAR-T efficacy in patients with diffuse large B-cell lymphoma

    Although chimeric antigen receptor (CAR) T cells have become an important treatment option for patients with relapsed/refractory B-cell malignancies,...

    Yao Wang, Chuan Tong, ... Weidong Han in Signal Transduction and Targeted Therapy

    Article Open access 25 October 2023
    

16. The effect of postoperative early lumbar drainage on delayed fever after cerebellopontine angle tumour surgery: study protocol for a randomized controlled trial

    Background

    Postoperative fever is one of the common complications in neurosurgery, and intracranial aseptic inflammation and infection are important...

    Yunze Zhang, Yingxi Wu, ... Tianzhi Zhao in Trials

    Article Open access 12 December 2022
    

17. Cancer-associated fibroblasts-derived HAPLN1 promotes tumour invasion through extracellular matrix remodeling in gastric cancer

    Background

    Cancer-associated fibroblasts (CAFs) are the most principal cells of depositing and remodeling extracellular matrix (ECM) within solid...

    Tiancheng Zhang, **ang Li, ... Lizong Shen in Gastric Cancer

    Article Open access 01 November 2021
    

18. CD44v3 is a marker of invasive cancer stem cells driving metastasis in gastric carcinoma

    Background

    Cancer stem cells (CSCs) are at the origin of tumour initiation and progression in gastric adenocarcinoma (GC). However, markers of...

    Julie Giraud, Lornella Seeneevassen, ... Christine Varon in Gastric Cancer

    Article Open access 18 December 2022
    

19. Multifaceted microglia — key players in primary brain tumour heterogeneity

    Microglia are the resident innate immune cells of the immune-privileged CNS and, as such, represent the first line of defence against tissue injury...

    Lily Keane, Mathilde Cheray, ... Bertrand Joseph in Nature Reviews Neurology

    Article 10 March 2021
    

20. Radiosynthesis and preclinical evaluation of [¹¹C]SNX-ab as an Hsp90α,β isoform-selective PET probe for in vivo brain and tumour imaging

    Background

    The molecular chaperone, Hsp90, is a key player in the protein quality control system that maintains homeostasis under cellular stress...

    Romy Cools, Koen Vermeulen, ... Guy Bormans in EJNMMI Radiopharmacy and Chemistry

    Article Open access 30 January 2023