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Claudin-10 is a new candidate prognostic marker in metastatic high-grade serous carcinoma
The objective of this study was to analyze the expression and prognostic role of the tight junction protein claudin-10 in high-grade serous carcinoma...
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Unraveling the molecular mechanisms of lymph node metastasis in ovarian cancer: focus on MEOX1
BackgroundLymph node metastasis (LNM) is a major factor contributing to the high mortality rate of ovarian cancer, making the treatment of this...
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MiR-585-3p suppresses tumor proliferation and migration by directly targeting CAPN9 in high grade serous ovarian cancer
BackgroundAberrant expression of microRNAs (miRNAs) contributes to the development of high grade serous ovarian cancer (HGSOC). However, the...
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The prognostic factor for recurrence in advanced-stage high-grade serous ovarian cancer after complete clinical remission: a nested case-control study
BackgroundWomen with advanced-stage high-grade serous ovarian cancer (HGSOC) are likely to have a bad prognosis. Relapses are common in patients even...
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Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer
PurposeSphingosine-kinase-1 (SPHK1) is a key enzyme of sphingolipid metabolism which is involved in ovarian cancer pathogenesis, progression and...
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Clinical analysis and artificial intelligence survival prediction of serous ovarian cancer based on preoperative circulating leukocytes
Circulating leukocytes are an important part of the immune system. The aim of this work is to explore the role of preoperative circulating leukocytes...
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Risk-reducing sal**o-oophorectomy among Chinese women at increased risk of breast and ovarian cancer
BackgroundRisk-reducing sal**o-oophorectomy (RRSO) is recommended for women at increased risk of breast and ovarian cancer. We launched a...
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Identification of potentially actionable genetic variants in epithelial ovarian cancer: a retrospective cohort study
Ovarian cancer is the most lethal gynecologic malignancy, mainly due to late-stage diagnosis, frequent recurrences, and eventually therapy...
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Mixed high-grade serous and large cell neuroendocrine carcinoma arising from rectal endometriosis 11 years after hysterectomy
The malignant gastrointestinal endometriosis transformation is represented by endometriosis-associated intestinal tumors. Endometrioid adenocarcinoma...
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High expression of RIPK2 is associated with Taxol resistance in serous ovarian cancer
BackgroundTaxol resistance in serous ovarian cancer is responsible for its poor prognosis, yet the underlying mechanism is still poorly understood....
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Hereditary breast and ovarian cancer triggered by occult fallopian tube cancer: a case report
BackgroundAt the time of benign gynecological surgery, a prophylactic sal**o-oophorectomy or sal**ectomy is increasingly being performed...
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Insights into high-grade serous carcinoma pathobiology using three-dimensional culture model systems
Epithelial ovarian cancer (EOC) research has become more complex as researchers try to fully understand the metastatic process. Especially as we...
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The intratumoral microbiota biomarkers for predicting survival and efficacy of immunotherapy in patients with ovarian serous cystadenocarcinoma
BackgroundOvarian serous cystadenocarcinoma, accounting for about 90% of ovarian cancers, is frequently diagnosed at advanced stages, leading to...
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Impact of BRCA Mutation Status on Tumor Dissemination Pattern, Surgical Outcome and Patient Survival in Primary and Recurrent High-Grade Serous Ovarian Cancer: A Multicenter Retrospective Study by the Ovarian Cancer Therapy-Innovative Models Prolong Survival (OCTIPS) Consortium
BackgroundThis study seeks to evaluate the impact of breast cancer ( BRCA ) gene status on tumor dissemination pattern, surgical outcome and survival...
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ZEB2 facilitates peritoneal metastasis by regulating the invasiveness and tumorigenesis of cancer stem-like cells in high-grade serous ovarian cancers
Peritoneal metastasis is a common issue in the progression of high-grade serous ovarian cancers (HGSOCs), yet the underlying mechanism remains...
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A case of synchronous serous ovarian cancer and uterine serous endometrial intraepithelial carcinoma
BackgroundSerous endometrial intraepithelial carcinoma (SEIC) is now considered to represent an early stage of uterine serous carcinoma (USC). It is...
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Exploration and prognostic analysis of two types of high-risk ovarian cancers: clear cell vs. serous carcinoma: a population-based study
BackgroundOvarian clear cell carcinoma (OCCC) is a rare pathological histotype in ovarian cancer, while the survival rate of advanced OCCC (Stage...
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Differences in the position of endometriosis-associated and non-associated ovarian cancer relative to the uterus
BackgroundPreoperative assessment of the histological type of ovarian cancer is essential to determine the appropriate treatment strategy. Tumor...
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High-Grade Endometrial Cancer: Molecular Subtypes, Current Challenges, and Treatment Options
Although many recent advancements have been made in women’s health, perhaps one of the most neglected areas of research is the diagnosis and...
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Comparison of clinical behavior between mucinous ovarian carcinoma with infiltrative and expansile invasion and high-grade serous ovarian carcinoma: a retrospective analysis
BackgroundThe aim of this study was to evaluate the clinicopathological factors and prognosis of mucinous carcinoma (MC) with infiltrative invasion,...
