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The emerging role and mechanism of HMGA2 in breast cancer
High mobility group AT-hook 2 (HMGA2) is a member of the non-histone chromosomal high mobility group (HMG) protein family, which participate in...
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Targeted Therapies in Pediatric Acute Myeloid Leukemia - Evolving Therapeutic Landscape
Acute myeloid leukemia (AML) accounts for 25% of all leukemia diagnosis and is characterized by distinct cytogenetic and molecular profile. Advances...
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Mutual interaction of lncRNAs and epigenetics: focusing on cancer
Long noncoding RNAs are characterized as noncoding transcripts longer than 200 nucleotides in response to a variety of functions within the cells....
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The RNA-binding protein IGF2BP3 is critical for MLL-AF4-mediated leukemogenesis
Despite recent advances in therapeutic approaches, patients with MLL-rearranged leukemia still have poor outcomes. Here, we find that the RNA-binding...
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Comprehensive molecular understanding of pediatric acute myeloid leukemia
Pediatric acute myeloid leukemia (AML) is a heterogeneous disease with various genetic abnormalities. Recent advances in genetic analysis have...
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Loss of IRF8 inhibits the growth of acute myeloid leukemia cells
The transcription factor interferon regulatory factor 8 (IRF8), as a member of the IRF family, is essential for myeloid cell differentiation....
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LncRNAs as epigenetic regulators of epithelial to mesenchymal transition in pancreatic cancer
Pancreatic cancer is the leading cause of cancer-related mortality because of tumor metastasis. Activation of the epithelial-to-mesenchymal...
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Emerging DNA Methylome Targets in FLT3-ITD-Positive Acute Myeloid Leukemia: Combination Therapy with Clinically Approved FLT3 Inhibitors
The internal tandem duplication (ITD) mutation of the FMS-like receptor tyrosine kinase 3 ( FLT3-ITD ) is the most common mutation observed in...
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Research hotspots and trends of microRNAs in intervertebral disc degeneration: a comprehensive bibliometric analysis
BackgroundMicroRNAs (miRNAs) are involved in various pathological processes, such as proliferation, growth, and apoptosis, of intervertebral disc...
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Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia
We investigated the role of Hoip, a catalytic subunit of linear ubiquitin chain assembly complex (LUBAC), in adult hematopoiesis and myeloid leukemia...
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Tespa1 facilitates hematopoietic and leukemic stem cell maintenance by restricting c-Myc degradation
Hematopoietic stem cells (HSCs) and leukemia stem cells (LSCs) have robust self-renewal potential, which is responsible for sustaining normal and...
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The advances of E2A-PBX1 fusion in B-cell acute lymphoblastic Leukaemia
The E2A-PBX1 gene fusion is a common translocation in B-cell acute lymphoblastic leukaemia. Patients harbouring the E2A-PBX1 fusion gene typically...
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Pathogenic Mechanisms in Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is the most common form of leukemia in adults, leading to the highest number of annual leukemia-associated deaths in the...
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Role of miRNAs to control the progression of Chronic Myeloid Leukemia by their expression levels
Chronic Myeloid Leukemia (CML) is a myeloproliferative disorder distinguished by a specific genetic anomaly known as a reciprocal translocation...
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Repeated spontaneous remission of acute myeloid leukemia in response to various infections: a case report
BackgroundAcute myeloid leukemia (AML) is a progressive hematological malignancy that can be fatal when left untreated. However, spontaneous...
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Current advances in noninvasive methods for the diagnosis of oral squamous cell carcinoma: a review
Oral squamous cell carcinoma (OSCC), one of the most common types of cancers worldwide, is diagnosed mainly through tissue biopsy. However, owing to...
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CEBPA mutations in acute myeloid leukemia: implications in risk stratification and treatment
Mutations in CCAAT enhancer binding protein α (CEBPA) occur in approximately 10% of patients with de novo acute myeloid leukemia (AML). Emerging...