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Airway IL-1β associates with IL-5 production following dust mite allergen inhalation in humans
BackgroundPreclinical studies implicate interleukin (IL)-1β as a key mediator of asthma and have shown the efficacy of IL-1 antagonism for treatment...
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Circulating miRNA expression in asthmatics is age-related and associated with clinical asthma parameters, respiratory function and systemic inflammation
BackgroundThe course of asthma may differ between elderly asthmatics (EA) and non-elderly asthmatics (nEA), which may be partially associated with an...
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Assessment of the role of fractional exhaled nitric oxide as a predictor of airway eosinophilia and corticosteroid responsiveness in patients with chronic cough
BackgroundFractional exhaled nitric oxide (FeNO) can be used as a rapid indicator of eosinophilic airway inflammation and steroid responsiveness in...
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The relationship between peak inspiratory flow and hand grip strength measurement in men with mild chronic obstructive pulmonary disease
BackgroundChronic obstructive pulmonary disease (COPD) decreases quality of life and muscular strength. Inspiratory flow is important for inhalants...
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Airway inflammation and lung function recovery after lobectomy in patients with primary lung cancer
ObjectiveFractional exhaled nitric oxide (FeNO), which represents airway inflammation, is an indicator of postoperative complication after lung...
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Clinical and cytokine patterns of uncontrolled asthma with and without comorbid chronic rhinosinusitis: a cross-sectional study
BackgroundAsthma is significantly related to chronic rhinosinusitis (CRS) both in prevalence and severity. However, the clinical patterns of...
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Characteristics of inflammatory phenotypes among patients with asthma: relationships of blood count parameters with sputum cellular phenotypes
BackgroundThere is a need to identify the asthma inflammatory phenotypes of patients to facilitate personalized asthma treatment. Sputum induction is...
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Allergien und schweres Asthma
Severe asthma accounts for 3-4% of all asthma cases and is associated with significant morbidity and mortality. While allergies play a central role...
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Change in exhaled nitric oxide during peanut challenge is related to severity of reaction
BackgroundPeanut allergy affects 3% of Australian children and has a higher risk of anaphylaxis than most food allergies. Predicting who is likely to...
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Treatment outcome clustering patterns correspond to discrete asthma phenotypes in children
Despite widely and regularly used therapy asthma in children is not fully controlled. Recognizing the complexity of asthma phenotypes and endotypes...
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Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma
BackgroundExtracellular DNA (e-DNA) and neutrophil extracellular traps (NETs) are linked to asthmatics airway inflammation. However, data...
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STOP: an open label crossover trial to study ICS withdrawal in patients with a combination of obesity and low-inflammatory asthma and evaluate its effect on asthma control and quality of life
BackgroundAsthma patients with obesity often have a high disease burden, despite the use of high-dose inhaled corticosteroids (ICS). In contrast to...
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Early lung diffusion abnormalities and airways’ inflammation in children with type 1 diabetes
Background and aims of the studyType 1 diabetes (T1D) impacts lung function and exercise capacity in adults, but limited information is available in...
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A feasibility study to assess Imbrasia belina (mopane worm) sensitisation and related respiratory health outcomes in a rural community in Gwanda district, Zimbabwe
BackgroundAllergic diseases are considered to be some of the fastest growing chronic conditions in Africa. Of concern is the paucity of knowledge...
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Effect of fractional exhaled nitric oxide (FENO)-based asthma management during pregnancy versus usual care on infant development, temperament, sensory function and autism signs
Asthma during pregnancy is associated with a range of adverse perinatal outcomes. It is also linked to increased rates of neurodevelopmental...
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