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Repeated greater occipital nerve injections with corticosteroids in medically intractable chronic cluster headache: a retrospective study
IntroductionCurrent prophylactic drugs for cluster headache are associated with limited efficacy, serious side effects and poor tolerability. Greater...
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Adding a fatigue item to the EQ-5D-5L improves its psychometric performance in the general population
BackgroundFatigue is a common and often disturbing sequela of serious chronic health conditions. In the widely applied HRQL instrument, the EQ-5D,...
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Pharmacokinetics and Pharmacodynamics of JNJ-55920839, an Antibody Targeting Interferon α/ω, in Healthy Subjects and Subjects with Mild-to-Moderate Systemic Lupus Erythematosus
BackgroundThe interferon (IFN) pathway has been correlated with clinical and serological markers of disease activity in patients with systemic lupus...
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Characterization of the central nervous system penetrant and selective purine P2X7 receptor antagonist JNJ-54175446 in patients with major depressive disorder
JNJ-54175446 is a selective purine P2X7 receptor (P2X7R) antagonist that attenuates microglial IL-1β/IL-18 release. In healthy volunteers,...
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Post COVID-19 condition and its physical, mental and social implications: protocol of a 2-year longitudinal cohort study in the Belgian adult population
BackgroundSince the onset of the COVID-19 pandemic, most research has focused on the pathophysiology and management of the acute symptoms of...
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The relation between EQ-5D and fatigue in a Dutch general population sample: an explorative study
BackgroundFatigue negatively influences health-related quality of life. It is questionable whether fatigue is sufficiently covered by the EQ-5D. This...
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Antibiotic Prescriptions Targeting Bacterial Respiratory Infections in Admitted Patients with COVID-19: A Prospective Observational Study
IntroductionAlthough bacterial co- and superinfections are rarely present in patients with COVID-19, overall antibiotic prescribing in admitted...