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Complex Regional Pain Syndrome (CRPS) and the Value of Early Detection
Purpose of ReviewThe goal of this narrative review is to describe the current understanding of the pathology of Complex Regional Pain Syndrome...
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Drug Repurposing to Target Neuroinflammation and Sensory Neuron-Dependent Pain
Around 20% of the American population have chronic pain and estimates in other Western countries report similar numbers. This represents a major...
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GFAP-NpHR mediated optogenetic inhibition of trigeminal nucleus caudalis attenuates hypersensitive behaviors and thalamic discharge attributed to infraorbital nerve constriction injury
The significance of hyperactive astrocytes in neuropathic pain is crucial. However, the association between medullary astrocytes and trigeminal...
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Trigeminal Postherpetic Neuralgia: From Pathophysiology to Treatment
Purpose of ReviewTrigeminal postherpetic neuralgia (TG-PHN) is a neuropathic pain condition complicating herpes zoster (HZ) attributed to the...
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Pain-resolving immune mechanisms in neuropathic pain
Interactions between the immune and nervous systems are of central importance in neuropathic pain, a common and debilitating form of chronic pain...
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Microbiological and Physiological Effects of Pain
Pain is an important innate defense mechanism that can dramatically alter a person’s quality of life. Understanding the microbiological and...
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Anti-osteoarthritis potential of peppermint and rosemary essential oils in a nanoemulsion form: behavioral, biochemical, and histopathological evidence
BackgroundThis study aimed to evaluate the effect of nanoemulsion containing peppermint and rosemary essential oils in rats with osteoarthritis (OA).
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Prognostic value of cutaneous reinnervation with GAP-43 in oxaliplatin-induced neuropathy
Background and purposeOxaliplatin-induced neuropathy (OIN) implies axonal damage of both small and large sensory nerve fibers. We aimed at comparing...
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Involvement between social defeat stress and pain-related behavior in a rat lumbar disk herniation model
IntroductionPsychological and social factors are involved in the disability and chronicity of pain. Our study aim was to investigate whether social...
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Complex Regional Pain Syndrome: Evidence-Based Advances in Concepts and Treatments
Purpose of ReviewThis review presents the most current information about the epidemiology of complex regional pain syndrome (CRPS), classification...
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A diminished sciatic nerve structural integrity is associated with distinct peripheral sensory phenotypes in individuals with type 2 diabetes
Aims/hypothesisQuantitative sensory testing (QST) allows the identification of individuals with rapid progression of diabetic sensorimotor...
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Association of Small Fiber Function with Microvascular Perfusion of Peripheral Nerves in Patients with Type 2 Diabetes
Introduction/aimsDiabetic small fiber neuropathy (SFN) is caused by damage to thinly myelinated A‑fibers (δ) and unmyelinated C‑fibers. This study...
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Debate: differences and similarities between tension-type headache and migraine
Tension-type headache (TTH) and migraine are two common primary headaches distinguished by clinical characteristics according to the 3 rd edition of...
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Direct paraventricular thalamus-basolateral amygdala circuit modulates neuropathic pain and emotional anxiety
The comorbidity of chronic pain and mental dysfunctions such as anxiety disorders has long been recognized, but the underlying mechanisms remained...
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A clinical approach to the investigation and management of long COVID associated neuropathic pain
COVID–19 has been associated with a wide range of ongoing symptoms following recovery from the acute SARS-CoV-2 infection. Around one in three people...
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Gut Microbiota Modulation and Its Implications on Neuropathic Pain: A Comprehensive Literature Review
Neuropathic pain (NP) is a chronic pain disorder arising from somatosensory nervous system impairment. Extensive evidence supports the notion that...
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From a Symptom-Based to a Mechanism-Based Pharmacotherapeutic Treatment in Complex Regional Pain Syndrome
Complex regional pain syndrome (CRPS) is a debilitating painful condition of a distal extremity that can develop after tissue damage. CRPS is thought...
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Clinical criteria and diagnostic assessment of fibromyalgia: position statement of the Italian Society of Neurology-Neuropathic Pain Study Group
BackgroundThe role of central and/or peripheral nervous system dysfunction is basically fundamental in fibromyalgia.
AimThe aim of this position...
