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Amino Acid Metabolism in Bone Metastatic Disease
Purpose of ReviewBreast and prostate tumors frequently metastasize to the bone, but the underlying mechanisms for osteotropism remain elusive. An...
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Circulating amino acids and acylcarnitines correlated with different CAC score ranges in diabetic postmenopausal women using LC–MS/MS based metabolomics approach
BackgroundDiabetes mellitus (DM) and its cardiovascular disease (CVD) complication are among the most frequent causes of death worldwide. However,...
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Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy
Amino acids are basic nutrients for immune cells during organ development, tissue homeostasis, and the immune response. Regarding metabolic...
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Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men
Aims/hypothesisObesity and insulin resistance may be associated with elevated plasma concentration of branched-chain amino acids (BCAAs) and impaired...
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Lipoprotein insulin resistance score and branched-chain amino acids increase after adrenalectomy for unilateral aldosterone-producing adenoma: a preliminary study
Background and aimsPrimary aldosteronism (PA) due to unilateral aldosterone-producing adenoma (APA) is preferentially treated by unilateral...
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Guanidine acetic acid supplementation altered plasma and tissue free amino acid profiles in finishing pigs
BackgroundAs a nutritive feed additive, guanidine acetic acid (GAA) participates in the metabolism of energy and proteins. This study aimed to...
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Leucine‑enriched essential amino acids promote muscle protein synthesis and ameliorate exercise-induced exhaustion in prolonged endurance exercise in rats
BackgroundLong-term endurance exercise results in muscle damage as well as muscle protein synthesis (MPS). Recovery from endurance exercise leads to...
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Protein, amino acids and obesity treatment
Dietary proteins have been used for years to treat obesity. Body weight loss is beneficial when it concerns fat mass, but loss of fat free mass –...
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Dietary amino acid patterns and cardiometabolic risk factors among subjects with obesity; a cross-sectional study
BackgroundThe prevalence of obesity is a growing global public health concern. Certain dietary amino acids have been shown to have a potential...
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Comparative study of the effect of neuromuscular electrical stimulation and oral administration of branched-chain amino acid on preventing sarcopenia in patients after living-donor liver transplantation: study protocol for an open-label randomized controlled trial
BackgroundLiver cirrhosis is the irreversible fibrosis of the liver and causes refractory ascites and hepatic encephalopathy, which might not respond...
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Possible-sarcopenic screening with disturbed plasma amino acid profile in the elderly
BackgroundThe mass and strength of skeletal muscle decline with age, leading to its progressive dysfunction. High-throughput metabolite profiling...
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Hyperglucagonaemia in diabetes: altered amino acid metabolism triggers mTORC1 activation, which drives glucagon production
Aim/hypothesisHyperglycaemia is associated with alpha cell dysfunction, leading to dysregulated glucagon secretion in type 1 and type 2 diabetes;...
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Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts
BackgroundAmino acid metabolism is dysregulated in colorectal cancer patients; however, it is not clear whether pre-diagnostic levels of amino acids...
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Tissue and plasma free amino acid detection by LC-MS/MS method in high grade glioma patients
PurposeThe changes in serum amino acid profiles are evaluated in different types of cancers and screening tests were developed for estimating the...
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Dietary Methionine and Total Sulfur Amino Acid Restriction in Healthy Adults
ObjectivesDietary restriction of methionine (Met) and cysteine (Cys) delays the aging process and aging-related diseases, improves glucose and fat...
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A blend of functional amino acids and grape polyphenols improves the pig capacity to cope with an inflammatory challenge caused by poor hygiene of housing conditions
BackgroundDietary supplementation with a blend of functional amino acids (AA) and grape extract polyphenols contributes to preserve intestinal health...
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Blood and faecal biomarkers to assess dietary energy, protein and amino acid efficiency of utilization by growing and finishing pigs
BackgroundDiet evaluation and optimization is a slow and expensive process and it is not possible to do it at a farm level. This study aimed to use...
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Targeted metabolomics profiling in pregnancy associated with vitamin D deficiency
BackgroundVitamin D deficiency is common in pregnancy, however, its effects has not been fully elucidated. Here, we conducted targeted metabolomics...
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Amino acid availability enhanced through glucose coadministration of amino acid supplementation during hemodiafiltration: two case reports
BackgroundIntravenous administration of amino acid (AA) formulation (IVAA) as intradialytic parenteral nutrition is widely used for malnourished...
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Edible traditional Chinese medicines improve type 2 diabetes by modulating gut microbiotal metabolites
Type 2 diabetes mellitus (T2DM) is a metabolic disorder with intricate pathogenic mechanisms. Despite the availability of various oral medications...
