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Chapter 2:indications and dosing of anticancer drug therapy in patients with impaired kidney function, from clinical practice guidelines for the management of kidney injury during anticancer drug therapy 2022
This comprehensive review discusses the dosing strategies of cancer treatment drugs for patients with impaired kidney function, specifically those...
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Mechanisms, Management and Prevention of Pemetrexed-Related Toxicity
Pemetrexed is a cytostatic antifolate drug and a cornerstone in the treatment of lung cancer. Although generally well tolerated, a substantial part...
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Exercise-induced Brugada pattern and ventricular tachycardia during Capecitabine treatment
We report the case of a 59-year-old female patient with no previous cardiovascular disease treated for Breast cancer with Capecitabine. Shortly after...
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Serine and one-carbon metabolisms bring new therapeutic venues in prostate cancer
Serine and one-carbon unit metabolisms are essential biochemical pathways implicated in fundamental cellular functions such as proliferation,...
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Network pharmacological analysis to reveal the mechanism governing the effect of Qin ** Tong on osteoarthritis and rheumatoid arthritis
IntroductionQin ** Tong (QXT), produced by water extracts of Caulis Sinomenii , is clinically effective in the therapy of rheumatoid arthritis (RA)....
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Cardioprotective potential of mitochondria-targeted antioxidant, mito-TEMPO, in 5-fluorouracil-induced cardiotoxicity
PurposeThe mitochondria-targeted antioxidants (MTAs) are known to offer protection against mitochondrial oxidative stress. The recent evidences...
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A case report of typhlitis during novel use of ropidoxuridine–capecitabine–radiotherapy for treatment-naïve rectal cancer
BackgroundRectal carcinomas are tumors that arise from the last 12 cm of the large intestine closest to the anus. They generally have a modest...
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Precision fluoropyrimidines dosing in a compound heterozygous variant carrier of the DPYD gene: a case report
BackgroundFluoropyrimidines (FPs) form still nowadays the backbone of chemotherapic schemes in colorectal cancer (CRC). Inter-patient variability of...
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Fluorouracil-induced leukoencephalopathy mimicking neuroleptic malignant syndrome: a case report
BackgroundFluorouracil-induced leukoencephalopathy is a rare complication and has been reported to present as confusion, oculomotor abnormality,...
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Chemical Composition, Pharmacological Effects and Clinical Applications of Cinobufacini
Chinese medicine cinobufacini is an extract from the dried skin of Bufo bufo gargarizans Cantor, with active ingredients of bufadienolides and indole...
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Targeting purine metabolism in ovarian cancer
Purine, an abundant substrate in organisms, is a critical raw material for cell proliferation and an important factor for immune regulation. The...
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Efficacy of topical 5-Fluorouracil in the management of ocular surface squamous neoplasia: a study of 101 eyes
ObjectiveTo study the efficacy and side-effect profile of topical 5-Fluorouracil (5-FU) in the treatment of ocular surface squamous neoplasia (OSSN).
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Blood cytopenias as manifestations of inherited metabolic diseases: a narrative review
Inherited Metabolic Diseases (IMD) encompass a diverse group of rare genetic conditions that, despite their individual rarity, collectively affect a...
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Selection of clinically relevant drug concentrations for in vitro studies of candidates drugs for cancer repurposing: a proposal
Drug repurposing of widely prescribed patent-off and cheap drugs may provide affordable drugs for cancer treatment. Nevertheless, many preclinical...
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Intralesional methotrexate versus 5-flurouracil in the treatment of keratoacanthoma
BackgroundKeratoacanthoma (KA) is a benign neoplasm that affects mainly photodamaged skin. It is locally destructive and may rarely spread. Surgery...
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Should we still be using bolus 5-FU prior to infusional regimens in gastrointestinal cancers? A practical review
5-fluorouracil (5-FU), a pyrimidine analogue with antimetabolite activity, is one of the most widely used drugs in Oncology and many different...
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Correlation between gene polymorphism and adverse reactions of high-dose methotrexate in osteosarcoma patients: a systematic review and meta-analysis
ObjectiveWe aimed to provide a reference based on evidence for an individualized clinical medication of high-dose methotrexate (HD-MTX) in...
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DTYMK is essential for genome integrity and neuronal survival
Nucleotide metabolism is a complex pathway regulating crucial cellular processes such as nucleic acid synthesis, DNA repair and proliferation. This...
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Cryptosporidium Genomics — Current Understanding, Advances, and Applications
Purpose of ReviewHere we highlight the significant contribution that genomics-based approaches have had on the field of Cryptosp oridium research and...
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Penile-scrotal erythrodysesthesia among rectal cancer patients receiving fluoropyrimidine-based chemoradiation: a case report series
BackgroundPalmar-plantar erythrodysesthesia (PPE) is a slowly develo** cutaneous reaction commonly experienced by patients treated with...
