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Neurobiology of rapid-acting antidepressants: convergent effects on GluA1-synaptic function
Efforts to develop efficacious antidepressant agents with novel mechanisms have been largely unsuccessful since the 1950’s until the discovery of...
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Novel Pharmacologic Strategies for Treating Behavioral Disturbances in Alzheimer’s Disease
Purpose of ReviewDevelo** pharmacological treatments to manage neuropsychiatric symptoms of Alzheimer’s disease is of high importance due to its...
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Prophylactic efficacy of 5-HT4R agonists against stress
Enhancing stress resilience could protect against stress-induced psychiatric disorders in at-risk populations. We and others have previously reported...
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Metabotropic glutamate receptor subtype 3 gates acute stress-induced dysregulation of amygdalo-cortical function
Stress can precipitate or worsen symptoms of many psychiatric disorders by dysregulating glutamatergic function within the prefrontal cortex (PFC)....
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Co-Activation of Metabotropic Glutamate Receptor 3 and Beta-Adrenergic Receptors Modulates Cyclic-AMP and Long-Term Potentiation, and Disrupts Memory Reconsolidation
Activation of β -adrenergic receptors ( β ARs) enhances both the induction of long-term potentiation (LTP) in hippocampal CA1 pyramidal cells and...
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Management of Dementia-Related Psychosis, Agitation and Aggression: A Review of the Pharmacology and Clinical Effects of Potential Drug Candidates
Along with cognitive decline, 90% of patients with dementia experience behavioral and psychological symptoms of dementia, such as psychosis,...
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Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity
Elevated activity at the output stage of the anterior hippocampus has been described as a physiological endophenotype of schizophrenia, and its...
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The Antidepressant Effects of an mGlu2/3 Receptor Antagonist and Ketamine Require AMPA Receptor Stimulation in the mPFC and Subsequent Activation of the 5-HT Neurons in the DRN
We have reported the antidepressant effects of both metabotropic glutamate 2/3 (mGlu2/3) receptor antagonists and ketamine in several animal models,...
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ACNP 57th Annual Meeting: Poster Session III
Sponsorship Statement: Publication of this supplement is sponsored by the ACNP.
Individual contributor disclosures may be found within the abstracts....
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Changes in serum levels of kynurenine metabolites in paediatric patients affected by ADHD
This study aims at determining serum levels of tryptophan and other metabolites of the kynurenine pathway in children with attention deficit...
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ACNP 57th Annual Meeting: Panels, Mini-Panels and Study Groups
Sponsorship Statement: Publication of this supplement is sponsored by the ACNP.
Individual contributor disclosures may be found within the abstracts.
As...
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Glial GLT-1 blockade in infralimbic cortex as a new strategy to evoke rapid antidepressant-like effects in rats
Ketamine and deep brain stimulation produce rapid antidepressant effects in humans and rodents. An increased AMPA receptor (AMPA-R) signaling in...
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Treatment for Negative Symptoms in Schizophrenia: A Comprehensive Review
Negative symptoms (such as amotivation and diminished expression) associated with schizophrenia are a major health concern. Adequate treatment would...
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Altered kynurenine pathway metabolites in serum of chronic migraine patients
BackgroundActivation of glutamate (Glu) receptors plays a key role in the pathophysiology of migraine. Both NMDA and metabotropic Glu receptors are...
