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Recent progress in the treatment of sickle cell disease: an up-to-date review
BackgroundSickle cell disease is a fatal systemic condition characterized by acute painful episodes, persistent anemia, ongoing organ damage, organ...
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Infizierte, pathologische Humerusfraktur bei Sichelzellanämie – noch ein Einzelfall?
The vaso-occlusive crises of sickle cell disease are accompanied by bone necrosis, which favors endogenous bacterial colonization and thus...
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Beyond pulmonary embolism: Alternative diagnosis and incidental findings on CT pulmonary angiography in sickle cell disease
BackgroundSickle cell disease (SCD) is a genetic hematological disorder associated with severe complications, such as vaso-occlusive crises, acute...
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Total hip replacement among sickle cell patients in a low-income country–Yemen
PurposeSickle cell patients presented with progressive hip pain and limitation of daily activities, as evidenced by low preoperative hip scores and...
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Transforming growth factor-β1: relation between its single-nucleotide genetic variants and sickle cell nephropathy
BackgroundSickle cell nephropathy is a complication of sickle cell disease characterized by functional abnormalities of the kidney and glomeruli. Our...
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Hydroxyurea and blood transfusion therapy for Sickle cell disease in South Asia: inconsistent treatment of a neglected disease
BackgroundHydroxyurea and blood transfusion therapies remain the main therapeutic strategies for Sickle cell disease. Preliminary data suggest...
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Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia with e1a3 BCR-ABL1 transcript in a Nigerian with sickle cell anemia: a case report
BackgroundThe occurrence of acute leukemia in patients with sickle cell anemia is uncommon. The Philadelphia chromosome is the hallmark of chronic...
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Neutrophil gelatinase–associated lipocalin as a biomarker of nephropathy in sickle cell disease
Sickle cell nephropathy (SCN) develops via altered hemodynamics and acute kidney injury, but conventional screening tests remain normal until...
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Postoperative acute multiple organ failure after hepatectomy in a Nigerian male with sickle cell trait: a case report
BackgroundSickle cell disease (SCD) is a monogenic disease characterized by sickle hemoglobin (HbS). Patients homozygous for HbS experience symptoms...
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The risk of acute events among patients with sickle cell disease in relation to early or late initiation of care at a specialist center: evidence from a retrospective cohort study
BackgroundThe greatest disease burden of sickle cell disease occurs early in life. Understanding factors that reduce disease related events in this...
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Improvement of SCD morbimortality in children: experience in a remote area of an African country
BackgroundSickle cell disease (SCD) is a public health problem in the Democratic Republic of Congo. While reference sickle cell centers have been...
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Cost analysis of acute care resource utilization among individuals with sickle cell disease in a middle-income country
BackgroundThe costs associated with the treatment of sickle cell disease (SCD) are understudied in low and middle-income countries (LMIC). We...
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The many faces of sickle cell disease in children: complications in the appendicular skeleton
Sickle cell disease (SCD) is a hereditary red cell disorder with clinical manifestations secondary to sickling or crescent-shaped distortion of the...
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Updating the role of transcranial Doppler in prediction and prevention of stroke in correlation to the regularity of blood transfusion in Egyptian children with sickle cell anemia
BackgroundThe Sickle cell disease (SCD) is a hemoglobinopathy that is recessively inherited commonly among people of Equatorial African, Saudi...
