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Human coronaviruses and therapeutic drug discovery
BackgroundCoronaviruses (CoVs) are distributed worldwide and have various susceptible hosts; CoVs infecting humans are called human coronaviruses...
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A proof-of-concept study on the use of a fluorescein-based 18F-tracer for pretargeted PET
BackgroundPretargeted immuno-PET tumor imaging has emerged as a valuable diagnostic strategy that combines the high specificity of antibody-antigen...
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Integrated in vivo and in silico evaluation of sweet basil oil as a protective agent against cisplatin-induced neurotoxicity in mice
BackgroundCisplatin is a wide-ranging antineoplastic drug. Neurotoxicity is one of cisplatin’s side effects that restrict its usage. This study aimed...
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Aspergillosis: an Update on Clinical Spectrum, Diagnostic Schemes, and Management
Purpose of ReviewThis review gives an overview of the diseases caused by Aspergillus , including a description of the species involved and the...
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Current Treatment of Chagas Disease
Purpose of reviewChagas disease (CD) is recognized as a neglected tropical disease. It is endemic of Latin America, but globalization has led to its...
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Adverse Drug Reaction of Antifungals in the Management of Black Fungus: A Tertiary Care Centre Experience
In India, COVID-19 has led to a surge in cases of a potentially fatal fungal infection called mucormycosis, popularly known as “black fungus.”...
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Chelator impact: investigating the pharmacokinetic behavior of copper-64 labeled PD-L1 radioligands
BackgroundProgrammed cell death ligand 1 (PD-L1) plays a critical role in the tumor microenvironment and overexpression in several solid cancers has...
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Learn from antibody–drug conjugates: consideration in the future construction of peptide-drug conjugates for cancer therapy
Cancer is one of the leading causes of death worldwide due to high heterogeneity. Although chemotherapy remains the mainstay of cancer therapy,...
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Antimicrobial resistance crisis: could artificial intelligence be the solution?
Antimicrobial resistance is a global public health threat, and the World Health Organization (WHO) has announced a priority list of the most...
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Highlight selection of radiochemistry and radiopharmacy developments by editorial board
BackgroundThe Editorial Board of EJNMMI Radiopharmacy and Chemistry releases a biannual highlight commentary to update the readership on trends in...
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Design, synthesis, and biological activity of TLR7-based compounds for chemotherapy-induced alopecia
Hair loss is a common dermatosis symptom and side-effect in cancer chemotherapeutics. Imiquimod application at mid and late telogen activated the...
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Drug conjugates for the treatment of lung cancer: from drug discovery to clinical practice
A drug conjugate consists of a cytotoxic drug bound via a linker to a targeted ligand, allowing the targeted delivery of the drug to one or more...
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Unravelling the myth surrounding sterol biosynthesis as plausible target for drug design against leishmaniasis
The mortality rate of leishmaniasis is increasing at an alarming rate and is currently second to malaria amongst the other neglected tropical...
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An overview of the developments and potential applications of 68Ga-labelled PET/CT hypoxia imaging
Non-invasive imaging of hypoxia plays a role in monitoring the body’s adaptive response or the development of pathology under hypoxic conditions....
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Test–retest reproducibility of cerebral adenosine A2A receptor quantification using [11C]preladenant
ObjectiveTo evaluate the reproducibility of cerebral adenosine A 2A receptor (A 2A R) quantification using [ 11 C]preladenant ([ 11 C]PLN) and PET in a...
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Novel [l,2,4]triazolo[3,4-a]isoquinoline chalcones as new chemotherapeutic agents: Block IAP tyrosine kinase domain and induce both intrinsic and extrinsic pathways of apoptosis
Two novel chemotherapeutic chalcones were synthesized and their structures were confirmed by different spectral tools. Theoretical studies such as...
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GMP-compliant production of [68Ga]Ga-NeoB for positron emission tomography imaging of patients with gastrointestinal stromal tumor
Background[ 68 Ga]Ga-NeoB is a novel DOTA-coupled Gastrin Releasing Peptide Receptor (GRPR) antagonist with high affinity for GRPR and good in vivo...
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Safety and Tolerability of Antimicrobial Agents in the Older Patient
Older patients are at high risk of infections, which often present atypically and are associated with high morbidity and mortality. Antimicrobial...
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In-silico and in-vitro assessments of some fabaceae, rhamnaceae, apocynaceae, and anacardiaceae species against Mycobacterium tuberculosis H37Rv and triple-negative breast cancer cells
Medicinal plants play a huge role in the treatment of various diseases in the Limpopo province (South Africa). Traditionally, concoctions used for...
