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DENND3 p.L708V activating variant is involved in the pathogenesis of hereditary hemochromatosis via the RAB12/TFR2 signaling pathway
PurposePathogenic variants in HFE and non- HFE genes have been identified in hereditary hemochromatosis (HH) in different patient populations, but...
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Research advances in the understanding of how exosomes regulate ferroptosis in cancer
Exosomes are extracellular vesicles that can release different bioactive substances to affect tumor cells and cell death pathways. As an important...
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The modulation of iron metabolism affects the Rhabdomyosarcoma tumor growth in vitro and in vivo
Rhabdomyosarcoma (RMS) is an aggressive rare neoplasm that derives from mesenchymal cells, which frequently develops resistance to the current...
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Targeting ferroptosis for leukemia therapy: exploring novel strategies from its mechanisms and role in leukemia based on nanotechnology
The latest findings in iron metabolism and the newly uncovered process of ferroptosis have paved the way for new potential strategies in...
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Fighting age-related orthopedic diseases: focusing on ferroptosis
Ferroptosis, a unique type of cell death, is characterized by iron-dependent accumulation and lipid peroxidation. It is closely related to multiple...
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The role of iron in host–microbiota crosstalk and its effects on systemic glucose metabolism
Iron is critical for the appearance and maintenance of life on Earth. Almost all organisms compete or cooperate for iron acquisition, demonstrating...
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Unlocking ferroptosis in prostate cancer — the road to novel therapies and imaging markers
Ferroptosis is a distinct form of regulated cell death that is predominantly driven by the build-up of intracellular iron and lipid peroxides....
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Recent advances in the potential effects of natural products from traditional Chinese medicine against respiratory diseases targeting ferroptosis
Respiratory diseases, marked by structural changes in the airways and lung tissues, can lead to reduced respiratory function and, in severe cases,...
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Effective delivery of anti-PD-L1 siRNA with human heavy chain ferritin (HFn) in acute myeloid leukemia cell lines
Because of the high biocompatibility, self-assembly capability, and CD71-mediated endocytosis, using human heavy chain ferritin (HFn) as a...
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Basic mechanisms and novel potential therapeutic targets for ferroptosis in acute myeloid leukemia
Ferroptosis is a form of cell death that is regulated by iron and characterized by the buildup of lipid peroxides (LPO) and subsequent rupture of the...
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The beneficial role of Hepcidin peptide inhibitor in improved the symptoms of COVID-19 in diabetics: anti-inflammatory and potential therapeutic effects
AbstractCoronavirus Disease 2019 (COVID-19) is a recent public health issue worldwide. Also, diabetes is a frequent condition with high mortality....
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Zooming in and out of ferroptosis in human disease
Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid peroxidation. In the past decade, it has been implicated in...
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Update on Therapy for Myotonic Dystrophy Type 1
Purpose of reviewThis review aimed to summarize the clinical characteristics of myotonic dystrophy type 1 and to provide a comprehensive review of...
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Targeting ferroptosis in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a common malignant tumor with complex survival mechanism and drug resistance, resulting in cancer-related high...
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Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal accumulation of iron-dependent membrane-localized lipid...
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Integrating iron metabolism-related gene signature to evaluate prognosis and immune infiltration in nasopharyngeal carcinoma
BackgroundDysregulation of iron metabolism has been shown to have significant implications for cancer development. We aimed to investigate the...
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The Role of P53 in Myocardial Ischemia-Reperfusion Injury
PurposeP53 is one of the key tumor suppressors. In normal cells, p53 is maintained at low levels by the ubiquitination of the ubiquitinated ligase...
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Mitochondrial Genetics and Function as Determinants of Bone Phenotype and Aging
Purpose of ReviewThe purpose of this review is to summarize the recently published scientific literature regarding the effects of mitochondrial...
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Sexually dimorphic effect of H-ferritin genetic manipulation on survival and tumor microenvironment in a mouse model of glioblastoma
PurposeIron plays a crucial role in various biological mechanisms and has been found to promote tumor growth. Recent research has shown that the...
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Iron accumulation and lipid peroxidation: implication of ferroptosis in diabetic cardiomyopathy
Diabetic cardiomyopathy (DC) is a serious heart disease caused by diabetes. It is unrelated to hypertension and coronary artery disease and can lead...
