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Genetic profile for dopamine signaling predicts brain functional reactivity to repetitive transcranial magnetic stimulation
Research integrating molecular and imaging data provides important insights into how the genetic profile associated with dopamine signaling...
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A systematic review of the potential effects of medications and drugs of abuse on dopamine transporter imaging using [123I]I-FP-CIT SPECT in routine practice
PurposeIn routine practice, dopamine transporter (DAT) imaging is frequently used as a diagnostic tool to support the diagnosis of Parkinson’s...
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Acute infusion of angiotensin II regulates organic cation transporters function in the kidney: its impact on the renal dopaminergic system and sodium excretion
A close relationship between angiotensin II (ANG II) and the renal dopaminergic system (RDS) has been reported. Our aim was to study whether renal...
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Tics: neurological disorders determined by a deficit in sensorimotor gating processes
Tic related disorders affect 4–20% of the population, mostly idiopathic, can be grouped in a wide spectrum of severity, where the most severe end is...
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Prescription Pattern of Monoamine Oxidase B Inhibitors Combined with Levodopa: A Retrospective Observational Analysis of Italian Healthcare Administrative Databases
BackgroundParkinson’s disease is still incurable, and several factors are considered when defining pharmacological therapy.
Objective ...
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Opicapone versus placebo in the treatment of Parkinson’s disease patients with end-of-dose motor fluctuation-associated pain: rationale and design of the randomised, double-blind OCEAN (OpiCapone Effect on motor fluctuations and pAiN) trial
BackgroundOptimisation of dopaminergic therapy may alleviate fluctuation-related pain in Parkinson’s disease (PD). Opicapone (OPC) is a...
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Advances in the Treatment of Cardiac Amyloidosis
Cardiac amyloidosis is associated with a high mortality rate, a long delay between the first signs and the diagnosis but a short interval between...
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Clinical, Cognitive, and Neurobiological Correlates of Impaired Timing Abilities Associate to Cannabis Use: a Systematic Review
Time perception received growing interest in psychiatry for its psychopathological implications. Cannabis use can cause a subjective experience of...
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Differential hippocampal protein expression between normal mice and mice with the perioperative neurocognitive disorder: a proteomic analysis
ObjectivesTo compare differential expression protein in hippocampal tissues from mice of perioperative neurocognitive disorder (PND) and normal...
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Are we creating a new phenotype? Physiological barriers and ethical considerations in the treatment of hereditary transthyretin-amyloidosis
Hereditary transthyretin (TTR) amyloidosis (ATTRv) is an autosomal dominant, systemic disease transmitted by amyloidogenic mutations in the TTR gene....
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Signaling pathways in Parkinson’s disease: molecular mechanisms and therapeutic interventions
Parkinson’s disease (PD) is the second most common neurodegenerative disease worldwide, and its treatment remains a big challenge. The pathogenesis...
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Optical molecular imaging and theranostics in neurological diseases based on aggregation-induced emission luminogens
Optical molecular imaging and image-guided theranostics benefit from special and specific imaging agents, for which aggregation-induced emission...
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Toxic interactions between dopamine, α-synuclein, monoamine oxidase, and genes in mitochondria of Parkinson’s disease
Parkinson’s disease is characterized by its distinct pathological features; loss of dopamine neurons in the substantia nigra pars compacta and...
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Liver Injury with Ulipristal Acetate: Exploring the Underlying Pharmacological Basis
IntroductionThe European Medicines Agency has suspended the use of ulipristal acetate (UPA) in the treatment of uterine fibroids and is reassessing...
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Hereditary transthyretin amyloidosis overview
Hereditary amyloidogenic transthyretin (ATTRv) amyloidosis is a rare autosomal dominantly inherited disorder caused by mutations in the transthyretin...
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Computational analysis to repurpose drugs for COVID-19 based on transcriptional response of host cells to SARS-CoV-2
BackgroundThe Coronavirus Disease 2019 (COVID-19) pandemic has infected over 10 million people globally with a relatively high mortality rate. There...
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Dopamine and Gambling Disorder: Prospects for Personalized Treatment
Purpose of ReviewTo address variation in the severity of gambling disorder, this review evaluates the contribution of mesocorticolimbic dopamine...
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The use or generation of biomedical data and existing medicines to discover and establish new treatments for patients with rare diseases – recommendations of the IRDiRC Data Mining and Repurposing Task Force
The number of available therapies for rare diseases remains low, as fewer than 6% of rare diseases have an approved treatment option. The...