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A novel and efficient CD22 CAR-T therapy induced a robust antitumor effect in relapsed/refractory leukemia patients when combined with CD19 CAR-T treatment as a sequential therapy
BackgroundCD19 chimeric antigen receptor (CAR) therapy has achieved impressive success in relapsed or refractory (R/R) B-cell malignancies, but...
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Efficacy of sequential TACE on primary hepatocellular carcinoma with microvascular invasion after radical resection: a systematic review and meta-analysis
ObjectivesThe purpose of this study is to examine the impact of sequential transcatheter arterial chemoembolization (TACE) on the prognosis of...
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Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy
Patients with chronic hepatitis B (CHB) undergoing interferon (IFN)-α-based therapies often exhibit a poor HBeAg serological response. Thus, there is...
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Stratified analysis of clinical pregnancy outcomes of sequential embryo transfer in frozen embryo transfer cycles based on different factors: a retrospective study
ObjectiveTo explore the effect of sequential embryo transfer (ET) on the pregnancy outcome of frozen-thawed embryo transfer (FET) cycle and the...
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Complications of Injected Exogenous Growth Factor for Cosmetic Facial Rejuvenation: A Case Series and Sequential Therapy
BackgroundExogenous growth factor presents promising soft tissue regeneration, but the complications from injectable exogenous growth factor seem to...
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Ten-day concomitant and sequential therapy for Helicobacter pylori effective in region with high antibiotic resistance rates
BackgroundIncreasing antibiotic-resistant Helicobacter pylori ( H. pylori ) strains complicate efforts to eradicate infection. In regions with high...
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Topical Chinese patent medicines for chronic musculoskeletal pain: systematic review and trial sequential analysis
PurposeChronic musculoskeletal pain (CMP) is defined as persistent or recurrent pain that occurs in the joints, musculo-soft tissue, spine or bones...
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Dalbavancin Sequential Therapy for Gram-Positive Bloodstream Infection: A Multicenter Observational Study
IntroductionLong-acting lipoglycopeptides such as dalbavancin may have utility in patients with Gram-positive bloodstream infections (BSI),...
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A meta-analysis and trial sequential analysis of randomised controlled trials comparing nonoperative and operative management of chest trauma with multiple rib fractures
BackgroundOperative treatment of traumatic rib fractures for better outcomes remains under debate. Surgical stabilization of rib fractures has...
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Modified risk-stratified sequential treatment (subcutaneous rituximab with or without chemotherapy) in B-cell Post-transplant lymphoproliferative disorder (PTLD) after Solid organ transplantation (SOT): the prospective multicentre phase II PTLD-2 trial
The prospective multicentre Phase II PTLD-2 trial (NCT02042391) tested modified risk-stratification in adult SOT recipients with CD20-positive PTLD...
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Managing Self-Harm Using Psychological Treatment ATMAN A Guide For Counsellors
The book presents the session wise details of ATMAN psychological treatment for managing self-harm in youth in low- and middle- income countries....
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A gated group sequential design for seamless Phase II/III trial with subpopulation selection
BackgroundDue to the high cost and high failure rate of Phase III trials where a classical group sequential design (GSD) is usually used, seamless...
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Pre- and Post-treatment Double-Sequential-Point Dynamic Radiomic Model in the Response Prediction of Gastric Cancer to Neoadjuvant Chemotherapy: 3-Year Survival Analysis
BackgroundPrognosis prediction of patients with gastric cancer after neoadjuvant chemotherapy is suboptimal. This study aims to develop and validate...
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A naturalistic study comparing the efficacy of unilateral and bilateral sequential theta burst stimulation in treating major depression – the U-B-D study protocol
BackgroundMajor depressive disorder (MDD) is a prevalent mental health condition affecting millions worldwide, leading to disability and reduced...
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Sustained response on sequential anti-FGFR therapy in metastatic gall bladder cancer: a case report and literature review
PurposeAdvanced gall bladder cancer (GBC) is an aggressive disease, and there is no consensus on treatment options beyond first-line chemotherapy. We...
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Assessing County-Level Behavioral Health and Justice Systems with the Sequential Intercept Model Practices, Leadership, and Expertise Scorecard
The Sequential Intercept Model has helped conceptualize interventions for people with serious mental illness in the criminal/legal system. This paper...
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Prophylactic tranexamic acid in Cesarean delivery: an updated meta-analysis with a trial sequential analysis
PurposePostpartum hemorrhage (PPH) is a leading cause of maternal mortality worldwide. Although several studies on the prophylactic use of tranexamic...
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Susceptibility‐guided sequential strategy versus empirical therapy for Helicobacter pylori infection: study protocol for a randomised controlled trial
BackgroundNew treatment strategies are required against infections caused by Helicobacter pylori, which grows increasingly resistant to antibiotics....
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Sequential non-invasive following short-term invasive mechanical ventilation in the treatment of tuberculosis with respiratory failure: a randomized controlled study
BackgroundInvasive and non-invasive mechanical ventilation (MV) have been combined as sequential MV in the treatment of respiratory failure. However,...
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Evaluation of live birth rates and perinatal outcomes following two sequential vitrification/warming events at the zygote and blastocyst stages
PurposeTo study the outcome of sequential cryopreservation-thawing of zygotes followed by the cryopreservation-thawing of blastocysts in the course...
