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PDLIM3 knockdown promotes ferroptosis in endometriosis progression via inducing Gli1 degradation and blocking Hedgehog signaling pathway
AimsCurrent evidence suggests that there is no completely effective method for endometriosis (EMS) without trauma due to diverse adverse effects....
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Sanguinarine chloride induces ferroptosis by regulating ROS/BACH1/HMOX1 signaling pathway in prostate cancer
BackgroundSanguinarine chloride (S.C) is a benzophenanthrine alkaloid derived from the root of sanguinaria canadensis and other poppy-fumaria...
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Identification of ferroptosis related genes and pathways in prostate cancer cells under erastin exposure
BackgroundFew studies are focusing on the mechanism of erastin acts on prostate cancer (PCa) cells, and essential ferroptosis-related genes (FRGs)...
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A polo-like kinase 1 inhibitor enhances erastin sensitivity in head and neck squamous cell carcinoma cells in vitro
BackgroundPolo-like kinase 1 (PLK1) is a critical therapeutic target in the treatment of head and neck squamous cell carcinoma (HNSCC). The objective...
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Targeting ferroptosis in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a common malignant tumor with complex survival mechanism and drug resistance, resulting in cancer-related high...
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BRD4 inhibitors broadly promote erastin-induced ferroptosis in different cell lines by targeting ROS and FSP1
Ferroptosis, an iron-dependent form of programmed cell death, is a promising strategy for cancer treatment. Bromodomain-containing protein 4 (BRD4)...
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FTH1 protects against osteoarthritis by MAPK pathway inhibition of extracellular matrix degradation
ObjectiveFerritin heavy chain 1 (FTH1) is an important subunit of ferro-storing proteins and is indispensable for iron metabolism. Though it has been...
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Induction of ferroptosis by photodynamic therapy and enhancement of antitumor effect with ferroptosis inducers
BackgroundPhotodynamic therapy (PDT) is an effective tumor treatment that involves the administration of a photosensitizer to generate cytotoxic 1 O 2 ...
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Unlocking ferroptosis in prostate cancer — the road to novel therapies and imaging markers
Ferroptosis is a distinct form of regulated cell death that is predominantly driven by the build-up of intracellular iron and lipid peroxides....
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Exosome is a Fancy Mobile Sower of Ferroptosis
Exosomes, nano-sized small extracellular vesicles, have been shown to serve as mediators between intercellular communications by transferring...
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Ferroptosis: a novel regulated cell death participating in cellular stress response, radiotherapy, and immunotherapy
BackgroundFerroptosis is a regulated cell death mode triggered by iron-dependent toxic membrane lipid peroxidation. As a novel cell death modality...
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Therapeutic Approaches Targeting Ferroptosis in Cardiomyopathy
The term cardiomyopathy refers to a group of heart diseases that cause severe heart failure over time. Cardiomyopathies have been proven to be...
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MiR-31-5p alleviates septic cardiomyopathy by targeting BAP1 to inhibit SLC7A11 deubiquitination and ferroptosis
Septic cardiomyopathy is one of the most severe and common complications in patients with sepsis and poses a great threat to their prognosis....
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Targeting ferroptosis opens new avenues for the development of novel therapeutics
Ferroptosis is an iron-dependent form of regulated cell death with distinct characteristics, including altered iron homeostasis, reduced defense...
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Basic mechanisms and novel potential therapeutic targets for ferroptosis in acute myeloid leukemia
Ferroptosis is a form of cell death that is regulated by iron and characterized by the buildup of lipid peroxides (LPO) and subsequent rupture of the...
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The multifaceted perspectives on the regulation of lncRNAs in hepatocellular carcinoma ferroptosis: from bench-to-bedside
Despite being characterized by high malignancy, high morbidity, and low survival rates, the underlying mechanism of hepatocellular carcinoma (HCC)...
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Relationship of mTORC1 and ferroptosis in tumors
Ferroptosis is a novel form of programmed death, dependent on iron ions and oxidative stress, with a predominant intracellular form of lipid...
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Jian Yun Qing Hua Decoction inhibits malignant behaviors of gastric carcinoma cells via COL12A1 mediated ferroptosis signal pathway
BackgroundJian Yun Qing Hua Decoction (JYQHD), a traditional Chinese medicine decoction, which has been applied in the treatment of gastric cancer...
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Integrated network pharmacology and experimental validation to explore the potential pharmacological mechanism of Qihuang Granule and its main ingredients in regulating ferroptosis in AMD
BackgroundQihuang Granule (QHG) is a traditional prescription that has exhibited potential in safeguarding against age-related maculopathy (AMD)....
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ALKBH5 decreases SLC7A11 expression by erasing m6A modification and promotes the ferroptosis of colorectal cancer cells
BackgroundColorectal cancer (CRC) is the major subtype of gastrointestinal malignancy and involves cancer-related genes and signaling pathways to...
