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Diabetes in patients with acromegaly treated with pegvisomant: observations from acrostudy
PurposeTo explore the effects of pegvisomant (PEGV) on glucose metabolism in patients with acromegaly within ACROSTUDY, an international,...
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Consensus on criteria for acromegaly diagnosis and remission
PurposeThe 14th Acromegaly Consensus Conference was convened to consider biochemical criteria for acromegaly diagnosis and evaluation of therapeutic...
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Partial response to first generation SSA guides the choice and predict the outcome of second line therapy in acromegaly
IntroductionTreatment of acromegaly resistant to first generation somatostatin analogues (first gen-SSA) is often difficult. We aimed to investigate...
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Conventional X-rays in the diagnosis and follow-up of vertebral fractures in patients with acromegaly: a real-life study
ObjectivesTo explore the role of conventional X-ray imaging in detecting vertebral fractures (VFs) in patients with acromegaly, both at diagnosis of...
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Disease control of acromegaly does not prevent excess mortality in the long term: results of a nationwide survey in Italy
ObjectiveThis study aimed to assess the long-term outcome of patients with acromegaly.
DesignThis is a multicenter, retrospective, observational...
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Systemic comorbidities of acromegaly in real-life experience: which difference among young and elderly patients?
IntroductionAcromegaly is a rare but potentially life-threatening disease, if not promptly managed, for the systemic complications due to the...
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Giant growth hormone-secreting pituitary adenomas from the endocrinologist’s perspective
ObjectivesSince giant (≥40 mm) GH-secreting pituitary adenomas are rarely encountered, data on their characteristics and treatment outcomes are...
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New findings on brain actions of growth hormone and potential clinical implications
Growth hormone (GH) is secreted by somatotropic cells of the anterior pituitary gland. The classical effects of GH comprise the stimulation of cell...
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Growth Hormone and Counterregulation in the Pathogenesis of Diabetes
Purpose of ReviewCanonical growth hormone (GH)-dependent signaling is essential for growth and counterregulatory responses to hypoglycemia, but also...
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Klinisch aktive Hypophysentumoren
The widespread use of diagnostic imaging has led to an increase in the incidence of pituitary tumors. The majority of incidentalomas are...
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Acromegaly increases depressive symptoms and reduces quality of life of cohabitants
PurposeTo assess how living with patients with acromegaly affects people’s psychology and quality of life (QoL).
MethodsAcromegaly patients and...
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Psychological complications in patients with acromegaly: relationships with sex, arthropathy, and quality of life
PurposeCurrent treatment of acromegaly restores a normal life expectancy in most cases. So, the study of persistent complications affecting patients’...
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Newer parameters of the octreotide test in patients with acromegaly
PurposePredicting the therapeutic effects of first-generation somatostatin receptor ligands (fg-SRLs) is important when assessing or planning...
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Is PEGylation of Drugs Associated with Hypersensitivity Reactions? An Analysis of the Italian National Spontaneous Adverse Drug Reaction Reporting System
Background and objectiveEvidence highlights the allergenic potential of PEGylated drugs because of the production of anti-polyethylene glycol...
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Consensus guideline for the diagnosis and management of pituitary adenomas in childhood and adolescence: Part 2, specific diseases
Pituitary adenomas are rare in children and young people under the age of 19 (hereafter referred to as CYP) but they pose some different diagnostic...