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Showing 41-60 of 10,000 results
  1. Both LDL and HDL particle concentrations associate positively with an increased risk of develo** microvascular complications in patients with type 2 diabetes: lost protection by HDL (Zodiac-63)

    Background

    Triglyceride-rich lipoproteins (TRL) and low-density lipoproteins (LDL) are associated positively whereas high-density lipoproteins (HDL)...

    Arno R. Bourgonje, Margery A. Connelly, ... Robin P. F. Dullaart in Cardiovascular Diabetology
    Article Open access 06 July 2023
  2. Treatment of node-positive endometrial cancer: chemotherapy, radiation, immunotherapy, and targeted therapy

    The standard of treatment for node-positive endometrial cancer (FIGO Stage IIIC) in North America has been systemic therapy with or without...

    Elizabeth A. Tubridy, Neil K. Taunk, Emily M. Ko in Current Treatment Options in Oncology
    Article Open access 04 January 2024
  3. Evaluation of the pharmacokinetics, dosimetry, and therapeutic efficacy for the α-particle-emitting transarterial radioembolization (αTARE) agent [225Ac]Ac-DOTA-TDA-Lipiodol® against hepatic tumors

    Background

    The liver is a common site for metastatic disease for a variety of cancers, including colorectal cancer. Both primary and secondary liver...

    Anders Josefsson, Angel G. Cortez, ... Jessie R. Nedrow in EJNMMI Radiopharmacy and Chemistry
    Article Open access 14 August 2023
  4. Protection from contamination by 211At, an enigmatic but promising alpha-particle-emitting radionuclide

    Purpose

    211 At, a promising alpha-particle-emitting radionuclide, can easily volatilize and contaminate the environment. To safely manage this unique...

    Kazunobu Ohnuki, Mitsuyoshi Yoshimoto, ... Hirofumi Fujii in EJNMMI Physics
    Article Open access 06 June 2022
  5. Current Status of PSMA-Targeted Radioligand Therapy in the Era of Radiopharmaceutical Therapy Acquiring Marketing Authorization

    Prostate-specific membrane antigen (PSMA) is highly expressed in PCa, which gradually increases in high-grade tumors, metastatic tumors, and tumors...

    So Won Oh, Minseok Suh, Gi Jeong Cheon in Nuclear Medicine and Molecular Imaging
    Article 20 August 2022
  6. Beyond Immune Checkpoint Inhibitors: Emerging Targets in Melanoma Therapy

    Purpose of review

    This review provides a comprehensive update on recent advancements in melanoma treatment by highlighting promising therapeutics with...

    Andrew D. Knight, Jason J. Luke in Current Oncology Reports
    Article 25 May 2024
  7. Photodynamic therapy in cancer stem cells — state of the art

    Despite significant efforts to control cancer progression and to improve oncology treatment outcomes, recurrence and tumor resistance are frequently...

    Ana Melissa C. Ibarra, Emilia Maria G. Aguiar, ... Maria Fernanda S. D. Rodrigues in Lasers in Medical Science
    Article 03 November 2023
  8. Ionizable drug delivery systems for efficient and selective gene therapy

    Gene therapy has shown great potential to treat various diseases by repairing the abnormal gene function. However, a great challenge in bringing the...

    Yu-Qi Zhang, Ran-Ran Guo, ... Gui-**a Ling in Military Medical Research
    Article Open access 27 February 2023
  9. Advances in Immune Tolerance Induction in Enzyme Replacement Therapy

    Inborn errors of metabolism (IEMs) are a group of genetic diseases that occur due to the either deficiency of an enzyme involved in a...

    Aslı İnci, Fatih Süheyl Ezgü, Leyla Tümer in Pediatric Drugs
    Article Open access 25 April 2024
  10. Co-delivery of dimeric camptothecin and chlorin e6 via polypeptide-based micelles for chemo-photodynamic synergistic therapy

    Background

    The integration of photodynamic therapy with a chemical drug-delivery system has displayed great potential in enhancing anticancer therapy....

    Zhaopei Guo, Ka Hong Wong, ... Meiwan Chen in Chinese Medicine
    Article Open access 13 October 2023
  11. Viral-mediated gene therapy in pediatric neurological disorders

    Background

    Due to the broad application of next-generation sequencing, the molecular diagnosis of genetic disorders in pediatric neurology is no...

    **g Peng, Wei-Wei Zou, ... Li Yang in World Journal of Pediatrics
    Article 06 January 2023
  12. Synergistic combination therapy using cowpea mosaic virus intratumoral immunotherapy and Lag-3 checkpoint blockade

    Immune checkpoint therapy (ICT) for cancer can yield dramatic clinical responses; however, these may only be observed in a minority of patients....

    Sweta Karan, Eunkyeong Jung, ... Nicole F. Steinmetz in Cancer Immunology, Immunotherapy
    Article Open access 13 February 2024
  13. Advanced methylene blue — nanoemulsions for in vitro photodynamic therapy on oral and cervical human carcinoma

    Photodynamic therapy (PDT) is a therapeutic modality with high contributions in the treatment of cancer. This approach is based on photophysical...

    Stéphanie R. do Amaral, Camila F. Amantino, ... Fernando L. Primo in Lasers in Medical Science
    Article 12 July 2022
  14. Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer

    Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens, including prolonged...

    Yun Yang, Qingya Liu, ... Zhiyong Qian in Signal Transduction and Targeted Therapy
    Article Open access 12 June 2024
  15. The impact of particle radiotherapy on the functioning of cardiac implantable electronic devices: a systematic review of in vitro and in vivo studies according to PICO criteria

    The number of oncological patients who may benefit from proton beam radiotherapy (PBT) or carbon ion radiotherapy (CIRT), overall referred to as...

    Amelia Barcellini, Veronica Dusi, ... Ester Orlandi in La radiologia medica
    Article Open access 24 July 2022
  16. Zn(II) porphyrin–encapsulated MIL-101 for photodynamic therapy of breast cancer cells

    The photodynamic treatment is a non-aggressive and clinically accepted procedure for removing selected cancer cells with the activation of a...

    Samaneh Hashemi Ghoochani, Hasan Ali Hosseini, ... Majid Darroudi in Lasers in Medical Science
    Article 28 June 2023
  17. Gene Therapy for Congenital Hearing Loss

    Purpose of Review

    This review provides the otolaryngology community with background on the basics of gene therapy for congenital hearing loss along...

    Alisa Timashpolsky, Stephen R. Chorney, Robert C. O’Reilly in Current Otorhinolaryngology Reports
    Article 05 September 2022
  18. Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy

    Immune checkpoint blockade (ICB) therapy for cancer has achieved great success both in clinical results and on the market. At the same time, success...

    Guang-Long Ma, Wei-Feng Lin in Military Medical Research
    Article Open access 28 April 2023
  19. Estimation of relative biological effectiveness of 225Ac compared to 177Lu during [225Ac]Ac-PSMA and [177Lu]Lu-PSMA radiopharmaceutical therapy using TOPAS/TOPAS-nBio/MEDRAS

    Aim

    Over recent years, [ 225 Ac]Ac-PSMA and [ 177 Lu]Lu-PSMA radiopharmaceutical therapy have evolved as a promising treatment option for advanced...

    Mikhail Rumiantcev, Wei Bo Li, ... Astrid Delker in EJNMMI Physics
    Article Open access 11 September 2023
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