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Both LDL and HDL particle concentrations associate positively with an increased risk of develo** microvascular complications in patients with type 2 diabetes: lost protection by HDL (Zodiac-63)
BackgroundTriglyceride-rich lipoproteins (TRL) and low-density lipoproteins (LDL) are associated positively whereas high-density lipoproteins (HDL)...
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Treatment of node-positive endometrial cancer: chemotherapy, radiation, immunotherapy, and targeted therapy
The standard of treatment for node-positive endometrial cancer (FIGO Stage IIIC) in North America has been systemic therapy with or without...
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Evaluation of the pharmacokinetics, dosimetry, and therapeutic efficacy for the α-particle-emitting transarterial radioembolization (αTARE) agent [225Ac]Ac-DOTA-TDA-Lipiodol® against hepatic tumors
BackgroundThe liver is a common site for metastatic disease for a variety of cancers, including colorectal cancer. Both primary and secondary liver...
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Protection from contamination by 211At, an enigmatic but promising alpha-particle-emitting radionuclide
Purpose211 At, a promising alpha-particle-emitting radionuclide, can easily volatilize and contaminate the environment. To safely manage this unique...
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Current Status of PSMA-Targeted Radioligand Therapy in the Era of Radiopharmaceutical Therapy Acquiring Marketing Authorization
Prostate-specific membrane antigen (PSMA) is highly expressed in PCa, which gradually increases in high-grade tumors, metastatic tumors, and tumors...
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Beyond Immune Checkpoint Inhibitors: Emerging Targets in Melanoma Therapy
Purpose of reviewThis review provides a comprehensive update on recent advancements in melanoma treatment by highlighting promising therapeutics with...
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Photodynamic therapy in cancer stem cells — state of the art
Despite significant efforts to control cancer progression and to improve oncology treatment outcomes, recurrence and tumor resistance are frequently...
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Ionizable drug delivery systems for efficient and selective gene therapy
Gene therapy has shown great potential to treat various diseases by repairing the abnormal gene function. However, a great challenge in bringing the...
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Advances in Immune Tolerance Induction in Enzyme Replacement Therapy
Inborn errors of metabolism (IEMs) are a group of genetic diseases that occur due to the either deficiency of an enzyme involved in a...
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Co-delivery of dimeric camptothecin and chlorin e6 via polypeptide-based micelles for chemo-photodynamic synergistic therapy
BackgroundThe integration of photodynamic therapy with a chemical drug-delivery system has displayed great potential in enhancing anticancer therapy....
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Viral-mediated gene therapy in pediatric neurological disorders
BackgroundDue to the broad application of next-generation sequencing, the molecular diagnosis of genetic disorders in pediatric neurology is no...
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Synergistic combination therapy using cowpea mosaic virus intratumoral immunotherapy and Lag-3 checkpoint blockade
Immune checkpoint therapy (ICT) for cancer can yield dramatic clinical responses; however, these may only be observed in a minority of patients....
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Advanced methylene blue — nanoemulsions for in vitro photodynamic therapy on oral and cervical human carcinoma
Photodynamic therapy (PDT) is a therapeutic modality with high contributions in the treatment of cancer. This approach is based on photophysical...
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Genetically programmable cell membrane-camouflaged nanoparticles for targeted combination therapy of colorectal cancer
Cell membrane-camouflaged nanoparticles possess inherent advantages derived from their membrane structure and surface antigens, including prolonged...
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The impact of particle radiotherapy on the functioning of cardiac implantable electronic devices: a systematic review of in vitro and in vivo studies according to PICO criteria
The number of oncological patients who may benefit from proton beam radiotherapy (PBT) or carbon ion radiotherapy (CIRT), overall referred to as...
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Zn(II) porphyrin–encapsulated MIL-101 for photodynamic therapy of breast cancer cells
The photodynamic treatment is a non-aggressive and clinically accepted procedure for removing selected cancer cells with the activation of a...
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Gene Therapy for Congenital Hearing Loss
Purpose of ReviewThis review provides the otolaryngology community with background on the basics of gene therapy for congenital hearing loss along...
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Immune checkpoint inhibition mediated with liposomal nanomedicine for cancer therapy
Immune checkpoint blockade (ICB) therapy for cancer has achieved great success both in clinical results and on the market. At the same time, success...
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Estimation of relative biological effectiveness of 225Ac compared to 177Lu during [225Ac]Ac-PSMA and [177Lu]Lu-PSMA radiopharmaceutical therapy using TOPAS/TOPAS-nBio/MEDRAS
AimOver recent years, [ 225 Ac]Ac-PSMA and [ 177 Lu]Lu-PSMA radiopharmaceutical therapy have evolved as a promising treatment option for advanced...