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The potential application of MR-derived ADCmin values from 68Ga-DOTATATE and 18F-FDG dual tracer PET/MR as replacements for FDG PET in assessment of grade and stage of pancreatic neuroendocrine tumors
BackgroundTo evaluate the utility of 68 Ga-DOTATATE and 18 F-FDG PET/MR for prediction of grade and stage of pancreatic neuroendocrine tumors (PNETs),...
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Efficacy and predictive factors of endoscopic ultrasound-guided ethanol ablation in benign solid pancreatic tumors
Backgrounds and ObjectivesEndoscopic ultrasound-guided ethanol ablation (EUS-EA) has recently been introduced for the management of solid pancreatic...
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A phase II study of sapanisertib (TAK-228) a mTORC1/2 inhibitor in rapalog-resistant advanced pancreatic neuroendocrine tumors (PNET): ECOG-ACRIN EA2161
This was a two-stage phase II trial of a mTORC1/2 inhibitor (mTORC: mammalian target of rapamycin complex) Sapanisertib (TAK228) in patients with...
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Sex-Based Clinicopathologic and Survival Differences Among Patients with Pancreatic Neuroendocrine Tumors
IntroductionSex-based differences in survival have emerged among patients with pancreatic neuroendocrine tumors (PNETs). Mechanisms driving these...
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Epidemiology and economic burden of Von Hippel-Lindau Disease-associated central nervous system hemangioblastomas and pancreatic neuroendocrine tumors in the United States
BackgroundTo date, real-world evidence around the clinical and economic burden related to von Hippel-Lindau (VHL) disease is limited. Therefore, this...
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A rare case of pancreatic neuroendocrine neoplasm causing Cushing’s syndrome
Pancreatic neuroendocrine neoplasms (PNENs) are relatively rare with a reported incidence of 1–2/100,000 and generally thought to originate from the...
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Neuroendocrine neoplasms in the context of inherited tumor syndromes: a reappraisal focused on targeted therapies
PurposeNeuroendocrine neoplasms can occur as part of inherited disorders, usually in the form of well-differentiated, slow-growing tumors (NET). The...
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Recurrence of Non-functional Pancreatic Neuroendocrine Tumors After Curative Resection: A Tumor Burden-Based Prediction Model
BackgroundPatients can experience recurrence following curative-intent resection of non-functional pancreatic neuroendocrine tumors (NF-pNETs). We...
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Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives
Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system....
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Pancreatic neuroendocrine neoplasms: a 2022 update for radiologists
Pancreatic neuroendocrine neoplasms (PaNENs) are a unique group of pancreatic neoplasms with a wide range of clinical presentations and behaviors....
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Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs): a radiomic model to predict tumor grade
PurposeThe aim of this single-center retrospective study is to assess whether contrast-enhanced computed tomography (CECT) radiomics analysis is...
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Pituitary neuroendocrine tumors: a model for neuroendocrine tumor classification
The classification of adenohypophysial neoplasms as “pituitary neuroendocrine tumors” (PitNETs) was proposed in 2017 to reflect their characteristics...
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The utility of 18F-FDG PET/CT in the diagnosis, staging of non-functioning pancreatic neuroendocrine tumors
BackgroundThe non-functional PNETs are often discovered incidentally, they are commonly malignant and commonly present at a late stage with large...
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A dose escalation/expansion study evaluating dose, safety, and efficacy of the novel tyrosine kinase inhibitor surufatinib, which inhibits VEGFR 1, 2, & 3, FGFR 1, and CSF1R, in US patients with neuroendocrine tumors
Surufatinib, is a potent inhibitor of vascular endothelial growth factor receptors 1–3; fibroblast growth factor receptor-1; colony-stimulating...
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What Is the Status of Immunotherapy in Neuroendocrine Neoplasms?
Abstract Purpose of ReviewImmunotherapy has changed the treatment of patients with advanced cancer, with different phase III trials showing durable...
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Pancreatic neuroendocrine tumor with stenosis of the main pancreatic duct leading to pancreatic pleural effusion: a case report
BackgroundPancreatic pleural effusion and ascites are defined as fluid accumulation in the thoracic and abdominal cavity, respectively, due to direct...
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Duodenum-Preserving Pancreatic Head Resection for Benign and Premalignant Tumors—a Systematic Review and Meta-analysis of Surgery-Associated Morbidity
BackgroundPancreatic benign, cystic, and neuroendocrine neoplasms are increasingly detected and recommended for surgical treatment. In multiorgan...
