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Showing 41-60 of 921 results

  1. Elucidating the importance and regulation of key enhancers for human MEIS1 expression

    Myeloid ecotropic virus insertion site 1 (MEIS1) is essential for normal hematopoiesis and is a critical factor in the pathogenesis of a large subset...

    ** **ang, **ning Yang, ... Arefeh Rouhi in Leukemia
    Article Open access 27 May 2022

  3. SETBP1 is dispensable for normal and malignant hematopoiesis

    SETBP1 is a potential epigenetic regulator whose hotspot mutations preventing proteasomal degradation are recurrently detected in myeloid...

    Atsushi Tanaka, Koutarou Nishimura, ... Daichi Inoue in Leukemia
    Article 18 July 2023

  4. Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation

    The identification of characteristic differences between cancer stem cells and their normal counterparts remains a key challenge for cancer...

    Koji Jimbo, Yaeko Nakajima-Takagi, ... Takaaki Konuma in Leukemia
    Article 13 April 2022

  5. A coordinated function of lncRNA HOTTIP and miRNA-196b underpinning leukemogenesis by targeting FAS signaling

    MicroRNAs (miRNAs) may modulate more than 60% of human coding genes and act as negative regulators, whereas long noncoding RNAs (lncRNAs) regulate...

    Ajeet P. Singh, Huacheng Luo, ... Suming Huang in Oncogene
    Article 29 November 2021

  6. A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth

    Background

    Chromosome translocations involving mixed lineage leukemia 1 (MLL1) cause acute leukemia in most infants and 5–10% children/adults with...

    **n Li, Yuan Yao, ... Yongcheng Song in Journal of Hematology & Oncology
    Article Open access 08 April 2022

  7. RNA binding proteins in MLL-rearranged leukemia

    RNA binding proteins (RBPs) have recently emerged as important post-transcriptional gene expression regulators in both normal development and...

    Tiffany M. Tran, Dinesh S. Rao in Experimental Hematology & Oncology
    Article Open access 28 October 2022

  8. Nucleic acid therapeutics as differentiation agents for myeloid leukemias

    Differentiation therapy has proven to be a success story for patients with acute promyelocytic leukemia. However, the remaining subtypes of acute...

    Olivia Kovecses, François E. Mercier, Maureen McKeague in Leukemia
    Article Open access 29 February 2024

  9. The gene mutation landscape of acute myeloid leukemia cell lines and its exemplar use to study the BCOR tumor suppressor

    Valentina Pettirossi, Alessandra Venanzi, ... Enrico Tiacci in Leukemia
    Article 12 January 2023

  10. Asxl1 deletion disrupts MYC and RNA polymerase II function in granulocyte progenitors

    Mutations in the gene Additional Sex-Combs Like 1 ( ASXL1 ) are recurrent in myeloid malignancies as well as the pre-malignant condition clonal...

    Theodore P. Braun, Joseph Estabrook, ... Julia E. Maxson in Leukemia
    Article 16 December 2022

  11. Prognostic value of Glypican family genes in early-stage pancreatic ductal adenocarcinoma after pancreaticoduodenectomy and possible mechanisms

    Background

    This study explored the prognostic significance of Glypican (GPC) family genes in patients with pancreatic ductal adenocarcinoma (PDAC)...

    Jun-Qi Liu, **-Wen Liao, ... Tao Peng in BMC Gastroenterology
    Article Open access 10 December 2020

  13. The EGR3 regulome of infant KMT2A-r acute lymphoblastic leukemia identifies differential expression of B-lineage genes predictive for outcome

    KMT2A -rearranged acute lymphoblastic infant leukemia ( KMT2A -r iALL) is associated with outsize risk of relapse and relapse mortality. We previously...

    Marius Külp, Patrizia Larghero, ... Rolf Marschalek in Leukemia
    Article Open access 26 April 2023

  14. Epigenetic Alternations in Endometrial Cancer; Future Strategies for Treatment

    Aim

    The incidence of endometrial cancer (EC) is increasing globally, with a projected continued rise in the number of affected individuals,...

    Fahimeh Nokhostin, Seyedeh Reyhaneh Yousefi Sharami, Elham Saffarieh in Indian Journal of Gynecologic Oncology
    Article 04 January 2024

  15. Identification of potential DNA methylation biomarkers related to diagnosis in patients with bladder cancer through integrated bioinformatic analysis

    Background

    Bladder cancer (BLCA) is one of the most common malignancies among tumors worldwide. There are no validated biomarkers to facilitate such...

    Hongxia Cheng, Yuhua Liu, Gang Chen in BMC Urology
    Article Open access 10 August 2023

  16. Trib1 promotes the development of acute myeloid leukemia in a Ts1Cje mouse model of Down syndrome

    Seiko Yoshino, Miwa Tanaka, ... Takuro Nakamura in Leukemia
    Article 11 August 2021

  17. Carcinogenic roles of MAFG-AS1 in human cancers

    The MAF bZIP transcription factor G-antisense RNA 1 (MAFG-AS1) is located on chromosome 17. MAFG-AS1 was upregulated in 15 human cancers. MAFG-AS1...

    Mohsen Ahmadi, Firouzeh Morshedzadeh, ... Soudeh Ghafouri-Fard in Clinical and Translational Oncology
    Article 23 June 2023
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