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Estetrol and Mammary Gland: Friends or Foes?
Estrogens have pleiotropic effects on many reproductive and non-reproductive tissues and organs including the mammary gland, uterus, ovaries, vagina,...
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Estrogen and bones after menopause: a reappraisal of data and future perspectives
Menopausal hormone therapy (MHT) is effective in preventing menopause-related bone loss and decreasing vertebral, non-vertebral and hip fracture...
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Differential Response to Mechanical Cues in Uterine Fibroid Versus Paired Myometrial Cells
Uterine leiomyomas, or fibroids, are common, benign tumors for which hysterectomy is the only definitive treatment. The extracellular matrix of...
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The estrogen receptor coactivator AIB1 is a new putative prognostic biomarker in ER-positive/HER2-negative invasive lobular carcinoma of the breast
PurposeAccording to the 2017 St Gallen surrogate definitions of the intrinsic subtypes, Ki67, progesterone receptor (PR) and Nottingham histological...
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Pregnancy-induced Cushing’s syndrome with an adrenocortical adenoma overexpressing LH/hCG receptors: a case report
BackgroundPregnancy-induced Cushing’s syndrome (CS) with an adrenocortical adenoma overexpressing luteinizing hormone (LH)/human choriogonadotropin...
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Excessive unilateral proliferation of spermatogonia in a patient with non-obstructive azoospermia – adverse effect of clomiphene citrate pre-treatment?
BackgroundClomiphene citrate has been proposed as pre-treatment for infertile men with non-obstructive, testicular azoospermia (NOA) before surgery...
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Progesterone distribution in the trigeminal system and its role to modulate sensory neurotransmission: influence of sex
BackgroundWomen are disproportionately affected by migraine, representing up to 75% of all migraine cases. This discrepancy has been proposed to be...
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Bisphenol A Exposure Enhances Endometrial Stromal Cell Invasion and Has a Positive Association with Peritoneal Endometriosis
Results of previous epidemiology studies on BPA exposure and endometriosis (EMs) risk were inconsistent, and were limited by inappropriate control...
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Prostaglandin E2 receptor 3 (EP3) signaling promotes migration of cervical cancer via urokinase-type plasminogen activator receptor (uPAR)
PurposeCervical cancer metastasis results in poor prognosis and increased mortality, which is not separated from inflammatory reactions accumulated...
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Exploring the potential benefits of anthocyanins for individuals with cerebral small vessel disease
Several studies have demonstrated the antioxidant and anti-inflammatory properties of anthocyanins, as well as their potential phytoestrogenic...
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The Effects of Clove and Its Constituents on Reproductive System: a Comprehensive Review
Clove with the scientific name of Syzygium aromaticum (L.) Merr. & L.M. Perry is an evergreen tree in which its buds are used for medicinal purposes....
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Protocol for a randomized controlled multicenter trial assessing the efficacy of leuprorelin for severe polycystic liver disease: the AGAINST-PLD study
BackgroundIn patients with severe polycystic liver disease (PLD), there is a need for new treatments. Estrogens and possibly other female sex...
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The Current Landscape of Pharmacotherapies for Sarcopenia
Sarcopenia is a skeletal muscle disorder characterized by progressive and generalized decline in muscle mass and function. Although it is mostly...
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The G protein-coupled estrogen receptor (GPER/GPR30) may serve as a prognostic marker in early-stage cervical cancer
BackgroundEstrogen signalling is transmitted via various receptors and multiple intracellular signalling pathways. Estrogen receptor alpha...
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Anti-SARS-CoV-2 potential of Cissampelos pareira L. identified by connectivity map-based analysis and in vitro studies
BackgroundViral infections have a history of abrupt and severe eruptions through the years in the form of pandemics. And yet, definitive therapies or...
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Expression of vasopressin and its receptors in migraine-related regions in CNS and the trigeminal system: influence of sex
BackgroundHypothalamus is a key region in migraine attacks. In addition, women are disproportionately affected by migraine. The calcitonin...
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Menopausal Hormonal Therapy and Breast Cancer
AbstractThe most common treatment for menopausal syndrome is menopausal hormone therapy (MHT), however, the safety of MHT, due to the risk of...
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Hypogonadism and nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD), recently proposed to be renamed to metabolic dysfunction-associated steatotic liver disease (MASLD), is a...
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Detangling the interrelations between MAFLD, insulin resistance, and key hormones
Metabolic dysfunction–associated fatty liver disease (MAFLD) has increasingly become a significant and highly prevalent cause of chronic liver...
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Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review
Research on obesity- and diabetes mellitus (DM)-related carcinogenesis has expanded exponentially since these two diseases were recognized as...
