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Loss of RNA-binding protein CELF2 promotes acute leukemia development via FAT10-mTORC1
RNA-binding proteins (RBPs) are critical regulators for RNA transcription and translation. As a key member of RBPs, ELAV-like family protein 2...
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Anemia and PET imaging
AimAnemia is a blood disorder characterized by reduced Hemoglobin concentration and/or red blood cells numbers. Most common causes of anemia are iron...
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The evolution of preclinical models for myelodysplastic neoplasms
Myelodysplastic Neoplasms (MDS) are a group of clonal disorders characterized by ineffective hematopoiesis and morphologic dysplasia. Clinical...
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Prevalence of extramedullary hematopoiesis, renal cysts, splenic and hepatic lesions, and vertebral hemangiomas among thalassemic patients: a retrospective study from the Myocardial Iron Overload in Thalassemia (MIOT) network
We determined the prevalence of incidental extracardiac findings (IEF) at Magnetic Resonance Imaging (MRI) potentially related to anemia and hypoxia...
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Novel treatments for myelofibrosis: beyond JAK inhibitors
Myelofibrosis is a chronic hematologic malignancy characterized by constitutional symptoms, bone marrow fibrosis, extramedullary hematopoiesis...
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The role of JAK inhibitors in hematopoietic cell transplantation
The Janus Kinase (JAK)/Signal Transducers and Activators of Transcription (STAT) pathway is essential for both the regulation of hematopoiesis and...
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The cellular composition and function of the bone marrow niche after allogeneic hematopoietic cell transplantation
Allogeneic hematopoietic cell transplantation (HCT) is a potentially curative therapy for patients with a variety of malignant and non-malignant...
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Progress of modern imaging modalities in multiple myeloma
Multiple myeloma (MM) is an incurable hematological malignancy, but treatment advances made in the last two decades have markedly improved its...
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Clinicopathological study of hepatic mesenchymal hamartoma and undifferentiated embryonal sarcoma of the liver: a single center study from Iran
BackgroundUndifferentiated embryonal sarcoma of liver (UESL) and hepatic mesenchymal hamartoma (HMH) are two rare entities which mainly affect the...
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A research review of experimental animal models with myelodysplastic syndrome
Myelodysplastic syndrome (MDS) consists of a group of hematologic tumors that are derived from the clonal proliferation of hematopoietic stem cells,...
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Acute myeloid leukemia with rare recurring translocations—an overview of the entities included in the international consensus classification
Two different systems exist for subclassification of acute myeloid leukemia (AML); the World Health Organization (WHO) Classification and the...
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Tumor-associated myeloid cells in cancer immunotherapy
Tumor-associated myeloid cells (TAMCs) are among the most important immune cell populations in the tumor microenvironment, and play a significant...
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Pathologic approach to Neonatal cholestasis with a simple scoring system for biliary atresia
A liver biopsy is essential for the diagnostic workup of persistent neonatal cholestasis (NC). The differential diagnosis of NC is broad, including...
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ASXL1/2 mutations and myeloid malignancies
Myeloid malignancies develop through the accumulation of genetic and epigenetic alterations that dysregulate hematopoietic stem cell (HSC)...
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Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development
Despite the advances in intensive chemotherapy regimens and targeted therapies, overall survival (OS) of acute myeloid leukemia (AML) remains...
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Overview of F18-FDG uptake patterns in retroperitoneal pathologies: imaging findings, pitfalls, and artifacts
IntroductionRetroperitoneum can be the origin of a wide variety of pathologic conditions and potential space for disease spread to other compartments...
