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Ervaringen en ondersteuningsbehoeften van leefstijlcoaches in het gebruik van digitale coachingsmiddelen bij cliënten met overgewicht
IntroductionIn the Netherlands, half of the adult population is overweight. Combined Lifestyle Interventions guide overweight clients towards...
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A First-in-Human Randomized Study to Assess the Safety, Tolerability, Pharmacokinetics, and Neutralization Profile of Two Investigational Long-Acting Anti-SARS-CoV-2 Monoclonal Antibodies
IntroductionCOVID-19 remains a significant risk for the immunocompromised given their lower responsiveness to vaccination or infection. Therefore,...
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Machine Learning Techniques Outperform Conventional Statistical Methods in the Prediction of High Risk QTc Prolongation Related to a Drug-Drug Interaction
In clinical practice, many drug therapies are associated with prolongation of the QT interval. In literature, estimation of the risk of prescribing...
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High Tolerability, Favorable Safety, and Subjects' Preference for a Single 200 mg/2 mL Tildrakizumab Injection: A Phase I, Open-Label, Randomized Crossover Trial in Healthy Volunteers
IntroductionTildrakizumab 200 mg/2 mL pre-filled syringe is a new preparation of tildrakizumab that is developed to facilitate patients’ compliance....
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The prevalence of non-pharmacological interventions in older homecare recipients: an overview from six European countries
PurposeNon-pharmacological interventions (NPIs) play an important role in the management of older people receiving homecare. However, little is known...
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Gender differences in the associations between childhood adversity and psychopathology in the general population
PurposeTo explore gender differences of the associations between childhood adversity (CA) subtypes and psychiatric symptoms in the general population.
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Anxiety and depression in people with post-COVID condition: a Belgian population-based cohort study three months after SARS-CoV-2 infection
PurposeSince the onset of the COVID-19 pandemic, most research has focused on the management of the acute symptoms of the disease. Yet some people...
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Effect of BI 1358894 on Cholecystokinin-Tetrapeptide (CCK-4)-Induced Anxiety, Panic Symptoms, and Stress Biomarkers: A Phase I Randomized Trial in Healthy Males
IntroductionDepression, anxiety, and/or panic disorder are often comorbid and have a complex etiology mediated through the same neuronal network....
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