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Elevated endogenous GDNF induces altered dopamine signalling in mice and correlates with clinical severity in schizophrenia
Presynaptic increase in striatal dopamine is the primary dopaminergic abnormality in schizophrenia, but the underlying mechanisms are not understood....
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Evaluating the burden of endogenous Cushing’s syndrome using a web-based questionnaire and validated patient-reported outcome measures
IntroductionEndogenous Cushing’s syndrome (CS) is a rare endocrine condition caused by chronic oversecretion of cortisol, resulting in a diverse...
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Endogenous Adenosine 5′-Monophosphate, But Not Acetylcholine or Histamine, is Associated with Asthma Control, Quality of Life, and Exacerbations
ObjectiveEndogenous adenosine 5′-monophosphate (AMP), acetylcholine (ACh), and histamine (HA) are known to be important in bronchial contraction, but...
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Endogenous Levels of Circulating Androgens Are Not Associated with Risk of Microscopic Colitis
BackgroundMicroscopic colitis is a chronic inflammatory disease that most commonly affects post-menopausal women. Exogenous hormone use has recently...
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The Effect of Praying on Endogenous Pain Modulation and Pain Intensity in Healthy Religious Individuals in Lebanon: A Randomized Controlled Trial
Prayer is considered to be the most common therapy used in alternative medicine. This study aimed to explore the effect of prayers on endogenous pain...
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Glucocorticoid Withdrawal Syndrome following treatment of endogenous Cushing Syndrome
Purpose:Literature regarding endogenous Cushing syndrome (CS) largely focuses on the challenges of diagnosis, subty**, and treatment. The enigmatic...
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An old model with new insights: endogenous retroviruses drive the evolvement toward ASD susceptibility and hijack transcription machinery during development
The BTBR T + Itpr3 tf /J (BTBR/J) strain is one of the most valid models of idiopathic autism, serving as a potent forward genetics tool to dissect the...
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Endogenous testosterone density as ratio of endogenous testosterone levels on prostate volume predicts tumor upgrading in low-risk prostate cancer
ObjectivesTo evaluate preoperative endogenous testosterone (ET) density (ETD), defined as the ratio of ET on prostate volume, and tumor upgrading...
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Risk for opioid misuse in chronic pain patients is associated with endogenous opioid system dysregulation
µ-Opioid receptors (MOR) are a major target of endogenous and exogenous opioids, including opioid pain medications. The µ-opioid neurotransmitter...
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The utility of IGF1 in the evaluation of pediatric patients with endogenous hypercortisolemia
BackgroundCushing Disease (CD) is a rare endocrine disorder associated with impaired growth hormone (GH) and short stature. Insulin-like growth...
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The role of endogenous opioids in mindfulness and sham mindfulness-meditation for the direct alleviation of evoked chronic low back pain: a randomized clinical trial
Chronic low back pain (cLBP) is the most prevalent chronic pain condition. There are no treatments that haven been found to directly assuage evoked...
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Construction of a novel nomogram based on competing endogenous RNAs and tumor-infiltrating immune cells for prognosis prediction in elderly patients with colorectal cancer
Competitive endogenous RNAs (ceRNAs) and tumor-infiltrating immune cells play essential roles in colorectal cancer (CRC) tumorigenesis. However,...
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Human endogenous retroviruses as epigenetic therapeutic targets in TP53-mutated diffuse large B-cell lymphoma
TP53 mutation ( TP53 mut ) occurs in 10–20% of diffuse large B-cell lymphoma (DLBCL) cases and serves as an unfavorable biomarker of DLBCL progression....
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National emergency department trends for endogenous endophthalmitis: an increasing public health challenge
Background/ObjectiveTo characterize incidence rates and identify risk factors for admission and mortality in patients with endogenous endophthalmitis...
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Effects of placebo administration on immune mechanisms and relationships with central endogenous opioid neurotransmission
Behavioral conditioning and expectation can have profound impact on animal and human physiology. Placebo, administered under positive expectation in...
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Cancer progression by the okadaic acid class of tumor promoters and endogenous protein inhibitors of PP2A, SET and CIP2A
PurposeOkadaic acid class of tumor promoters are transformed into endogenous protein inhibitors of PP2A, SET, and CIP2A in human cancers. This...
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Preoperative endogenous testosterone density predicts disease progression from localized impalpable prostate cancer presenting with PSA levels elevated up to 10 ng/mL
ObjectiveTo investigate endogenous testosterone density (ETD) predicting disease progression from clinically localized impalpable prostate cancer...
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Insertional Variations of Human Endogenous Virus K6 and K11 in Normozoospermic Men
Male infertility is a multifactorial heterogeneous reproductive disorder in which genetic, epigenetic, and environmental factors play a role in the...
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Clinical characteristics of endogenous Klebsiella pneumoniae endophthalmitis: a 13-year experience
PurposeThis study aimed to investigate the clinical features and risk factors for poor visual outcomes in patients with endogenous Klebsiella...