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The Influence of Underlying Disease on Rituximab Pharmacokinetics May be Explained by Target-Mediated Drug Disposition
Background and ObjectivesRituximab is an anti-CD20 monoclonal antibody approved in several diseases, including chronic lymphocytic leukemia (CLL),...
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One size does not fit all: the personal nature of completed embryo donation
PurposeTo assess factors associated with embryo donation among individuals interested in donation in the United States.
MethodsAn invitation to...
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Analysis of 2141 pediatric craniopharyngioma admissions in the USA utilizing the Kids’ Inpatient Database (KID): predictors of discharge disposition
ObjectivesTo recognize the national trends in management of pediatric craniopharyngioma and to address the significant predictors of discharge...
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Correlation between intracranial pressure monitoring for severe traumatic brain injury with hospital length of stay and discharge disposition: a retrospective observational cohort study
ObjectivesIntracranial pressure (ICP) monitoring is recommended for severe traumatic brain injuries (TBI) but some data suggests it may not improve...
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Attitudes, concerns, and perceptions of patients undergoing fertility treatments in an abortion restrictive state in the aftermath of the Roe v. Wade reversal
PurposeTo investigate the abortion views and reproductive concerns of current in vitro fertilization patients after the US Supreme Court Dobbs v. ...
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Disposition of Oral Cannabidiol-Rich Cannabis Extracts in Children with Epilepsy
Background and ObjectivesDespite limited evidence, cannabidiol-rich cannabis extracts have been popularly used in pediatrics. With increased use, it...
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Effects of dulaglutide and trelagliptin on beta-cell function in patients with type 2 diabetes: a randomized controlled study: DUET-beta study
AimsThis randomized, open-label, parallel-group, controlled trial compared the effects of dulaglutide and trelagliptin on beta-cell function in...
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Mass balance, metabolic disposition, and pharmacokinetics of a novel selective inhibitor of PI3Kδ [14C] SHC014748M in healthy Chinese subjects following oral administration
PurposeSHC014748M is a potent, novel selective PI3Kδ isoform inhibitor and is proposed for the treatment of non-Hodgkin lymphoma and chronic...
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Point-of-care ultrasound: impact on emergency department length of stay for suspected lower extremity DVT
BackgroundPoint-of-care ultrasound (POCUS) has demonstrated excellent sensitivity and specificity for the diagnosis of DVT in the emergency...
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Effectiveness of a critical reflection competency program for clinical nurse educators: a pilot study
BackgroundCritical reflection is an effective learning strategy that enhances clinical nurses’ reflective practice and professionalism. Therefore,...
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Health care impact of implementing a clinical pathway for acute care of pediatric concussion: a stepped wedge, cluster randomised trial
ObjectivesTo test the effects of actively implementing a clinical pathway for acute care of pediatric concussion on health care utilization and costs.
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Long-term clinical outcomes in critically ill patients with sepsis and pre-existing low muscle mass: a retrospective cohort study
PurposeCritically ill patients with sepsis account for significant disease morbidity and healthcare costs. Low muscle mass has been proposed as an...
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Predictors of In-Hospital Mortality and Home Discharge in Patients with Aneurysmal Subarachnoid Hemorrhage: A 4-Year Retrospective Analysis
BackgroundFactors associated with discharge disposition and mortality following aneurysmal subarachnoid hemorrhage (aSAH) are not well-characterized....
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OPTINOFA – Intelligenter Assistenzdienst zur strukturierten Ersteinschätzung in der Notaufnahme
BackgroundCase numbers in central emergency departments (EDs) have risen during the past decade in Germany, leading to recurrent overcrowding,...
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Preoperative patient-reported physical health-related quality of life predicts short-term postoperative outcomes in brain tumor patients
BackgroundPatient-reported outcome measures (PROMs) are increasingly used to assess patients’ perioperative health. The PROM Information System 29...
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Complications Following Body Contouring: Performance Validation of Bard, a Novel AI Large Language Model, in Triaging and Managing Postoperative Patient Concerns
IntroductionLarge language models (LLM) have revolutionized the way humans interact with artificial intelligence (AI) technology, with marked...
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A descriptive and comparative analysis of injuries reported in USA Cycling-sanctioned competitive road cycling events
BackgroundCompetition in road cycling events is common, yet little is known about the nature and disposition of injuries sustained in these events....
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A National Survey on Coma Epidemiology, Evaluation, and Therapy in India: Revisiting the Curing Coma Campaign Come Together Survey
BackgroundThe limited representation from develo** countries in the original COME TOGETHER survey gave us an impetus to conduct this survey in the...
