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Integrative blood-derived epigenetic and transcriptomic analysis reveals the potential regulatory role of DNA methylation in ankylosing spondylitis
BackgroundThe currently known risk loci could explain a small proportion of the heritability of ankylosing spondylitis (AS). Epigenetics might...
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DNA methylation landscape in pregnancy-induced hypertension: progress and challenges
Gestational hypertension (PIH), especially pre-eclampsia (PE), is a common complication of pregnancy. This condition poses significant risks to the...
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DNA Methylation in the Adaptive Response to Exercise
Emerging evidence published over the past decade has highlighted the role of DNA methylation in skeletal muscle function and health, including as an...
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Mitochondrial DNA damage triggers spread of Parkinson’s disease-like pathology
In the field of neurodegenerative diseases, especially sporadic Parkinson’s disease (sPD) with dementia (sPDD), the question of how the disease...
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Detection of small ruminant Lentivirus proviral DNA in red deer from Poland
Small ruminant lentiviruses (SRLVs) are widespread and infect goats and sheep. Several reports also suggest that SRLVs can infect wild ruminants. The...
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Cuproptosis-related DNA methylation signature predict prognosis and immune microenvironment in cutaneous melanoma
The prognosis for Cutaneous Melanoma (CM), a skin malignant tumor that is extremely aggressive, is not good. A recently identified type of controlled...
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The intervertebral discs’ fibrocartilage as a DNA source for genetic identification in severely charred cadavers
Identifying charred human remains poses a challenge to forensic laboratories. High temperature completely incinerates the superficial tissues and...
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The use of vitreous humour as a potential source of DNA for postmortem identification in forensic science
Vitreous humour (VH) is routinely collected for toxicological analyses. However, only a few studies have examined its possible use in genoty**....
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Extrachromosomal circular DNA (eccDNA): from carcinogenesis to drug resistance
Extrachromosomal circular DNA (eccDNA) is a circular form of DNA that exists outside of the chromosome. Although it has only been a few decades since...
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DNA and protein analyses of hair in forensic genetics
Hair is one of the most common pieces of biological evidence found at a crime scene and plays an essential role in forensic investigation. Hairs,...
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Identifying key factors for predicting O6-Methylguanine-DNA methyltransferase status in adult patients with diffuse glioma: a multimodal analysis of demographics, radiomics, and MRI by variable Vision Transformer
PurposeThis study aimed to perform multimodal analysis by vision transformer (vViT) in predicting O6-methylguanine-DNA methyl transferase (MGMT)...
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Circulating Tumor DNA (ctDNA) and Its Role in Gynecologic Malignancies
Circulating tumor DNA (ctDNA) refers to small fragments of DNA released into the bloodstream by cancer cells. It is obtained through “liquid biopsy;"...
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DNA methylation provides diagnostic value for meningioma recurrence in clinical practice
BackgroundMeningiomas are the most common intracranial tumors. Recent advancements in the genetic profiling of tumors have allowed information...
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Alterations in DNA methylation machinery in a rat model of osteoarthritis of the hip
BackgroundThis study aimed to validate alterations in the gene expression of DNA methylation-related enzymes and global methylation in the peripheral...
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HJURP is recruited to double-strand break sites and facilitates DNA repair by promoting chromatin reorganization
HJURP is overexpressed in several cancer types and strongly correlates with patient survival. However, the mechanistic basis underlying the...
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Severe induction of aberrant DNA methylation by nodular gastritis in adults
BackgroundNodular gastritis (NG) is characterized by marked antral lymphoid follicle formation, and is a strong risk factor for diffuse-type gastric...
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In situ analysis of hepatitis B virus (HBV) antigen and DNA in HBV-induced hepatocellular carcinoma
AimsHepatitis B Virus (HBV) infection is the major risk factor for hepatocellular carcinoma (HCC) in East Asia. Here we aimed to further investigate...
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Eye and hair color prediction of human DNA recovered from Lucilia sericata larvae
Forensic entomological evidence is employed to estimate minimum postmortem interval (PMImin), location, and identification of fly samples or human...
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Differential DNA methylation associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a systematic review
Recent studies suggest that differential DNA methylation could play a role in the mechanism of cerebral vasospasm (CVS) and delayed cerebral ischemia...
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DNA methylation subtypes guiding prognostic assessment and linking to responses the DNA methyltransferase inhibitor SGI-110 in urothelial carcinoma
BackgroundAt present, the extent and clinical relevance of epigenetic differences between upper tract urothelial carcinoma (UTUC) and urothelial...
