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Nephroblastoma-specific dysregulated gene SNHG15 with prognostic significance: scRNA-Seq with bulk RNA-Seq data and experimental validation
Wilms tumor (WT) is the most common malignancy of the genitourinary system in children. Currently, the Integration of single-cell RNA sequencing...
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Bioinformatic analysis of underlying mechanisms of Kawasaki disease via Weighted Gene Correlation Network Analysis (WGCNA) and the Least Absolute Shrinkage and Selection Operator method (LASSO) regression model
BackgroundKawasaki disease (KD) is a febrile systemic vasculitis involvingchildren younger than five years old. However, the specific biomarkers and...
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The uprise of RNA biology in neuroendocrine neoplasms: altered splicing and RNA species unveil translational opportunities
Neuroendocrine neoplasms (NENs) comprise a highly heterogeneous group of tumors arising from the diffuse neuroendocrine system. NENs mainly originate...
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Machine learning and experimental validation to construct a metastasis-related gene signature and ceRNA network for predicting osteosarcoma prognosis
ObjectiveOsteosarcoma (OS) is more common in adolescents and significantly harmful, and the survival rate is considerably low, especially in patients...
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Bioinformatics analysis of a disease-specific lncRNA–miRNA–mRNA regulatory network in recurrent spontaneous abortion (RSA)
BackgroundThis study investigated the molecular mechanisms of long non-coding RNAs (lncRNAs) in RSA using the lncRNA–miRNA–mRNA regulatory network.
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Integrated analysis of ceRNA network reveals potential prognostic Hint1-related lncRNAs involved in hepatocellular carcinoma progression
BackgroundHint1 is a novel tumor suppressor gene, and inactivation of its expression is closely associated with the carcinogenesis of a variety of...
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Transcriptome sequencing and microRNA–mRNA regulatory network construction in the lens from a Na2SeO3-induced Sprague Dawley rat cataract model
BackgroundA sight-threatening, cataract is a common degenerative disease of the ocular lens. This study aimed to explore the regulatory mechanism of...
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RNA 5-methylcytosine writer NSUN5 promotes hepatocellular carcinoma cell proliferation via a ZBED3-dependent mechanism
Hepatocellular carcinoma (HCC) is one of the leading contributors to cancer-related mortality worldwide. Nop2/Sun domain family member 5 (NSUN5), a...
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Long non-coding RNA LOXL1-AS1: a potential biomarker and therapeutic target in human malignant tumors
Long non-coding RNAs (lncRNAs) are transcripts that contain more than 200 nucleotides. Despite their inability to code proteins, multiple studies...
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Identification and bioinformatics analysis of lncRNAs in serum of patients with ankylosing spondylitis
ObjectivesThe aim of this study was to explore the long non-coding RNA (lncRNA) expression profiles in serum of patients with ankylosing spondylitis...
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Ultra-conserved RNA: a novel biological tool with diagnostic and therapeutic potential
Ultra-conserved RNA (ucRNA) is a subset of long non-coding RNA, that is highly conserved among mice, rats and humans. UcRNA has attracted extensive...
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ceRNA network development and tumor-infiltrating immune cell analysis in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is among the primary causes of cancer deaths globally. Despite efforts to understand liver cancer, its high morbidity...
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Deciphering the landscape of lncRNA-driven ceRNA network in schizophrenia etiology
BackgroundThe unifying hypothesis of competing endogenous RNA (ceRNA) wherein crosstalk between coding (mRNAs) and long non-coding RNAs (lncRNAs) via...
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Emerging roles of long non-coding RNA FTX in human disorders
Long non-coding RNAs (lncRNAs) are involved the progression of cancerous and non-cancerous disorders via different mechanism. FTX (five prime to...
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RNA-binding proteins in cardiovascular biology and disease: the beat goes on
Cardiac development and function are becoming increasingly well understood from different angles, including signalling, transcriptional and...
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ceRNA Network and WGCNA Analyses of Differentially Expressed Genes in Cervical Cancer Tissues for Association with Survival of Patients
The study aims to search and identify differentially expressed genes (DEGs) in cervical cancer tissues as novel biomarkers to predict cervical cancer...
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Transcriptional landscape of intestinal environment in DSS-induced ulcerative colitis mouse model
Ulcerative colitis (UC) is a chronic inflammatory disease that targets the colon and has seen an increasing prevalence worldwide. In our pursuit of...
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Integrative analysis of long noncoding RNAs dysregulation and synapse-associated ceRNA regulatory axes in autism
Autism spectrum disorder (ASD) is a complex disorder of neurodevelopment, the function of long noncoding RNA (lncRNA) in ASD remains essentially...
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RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial–myometrial interface
BackgroundUterine adenomyosis is associated with chronic pelvic pain, abnormal uterine bleeding, and infertility. The pathogenesis of adenomyosis is...
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Identification of prognostic genes signature and construction of ceRNA network in pirarubicin treatment of triple-negative breast cancer
BackgroundThe altered long non-coding RNA (lncRNA), circular RNA (circRNA) and mRNA expression in triple-negative breast cancer (TNBC) after...
