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Herbal formula Huangqi Guizhi Wuwu decoction attenuates paclitaxel-related neurotoxicity via inhibition of inflammation and oxidative stress
BackgroundPaclitaxel-induced peripheral neuropathy (PIPN) is a challenging clinical problem during chemotherapy. Our previous work found that herbal...
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Phenoty** of chronic pain in breast cancer survivors: an original study using the cancer pain phenoty** (CANPPHE) Network multidisciplinary international guidelines
PurposeThe primary aim of this cross-sectional study is to examine the prevalence of pain phenotypes in breast cancer survivors (BCS). A secondary...
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Complex regional pain syndrome: diagnostic challenges and favorable response to prednisolone
Complex regional pain syndrome (CRPS), characterized by severe and disproportionate pain, is a rare and debilitating condition. Due to its rarity,...
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The role of protein kinases in diabetic neuropathic pain: an update review
ObjectivesDiabetic neuropathic pain (DNP) is a debilitating symptom of diabetic neuropathy which seriously impairs patient’s quality of life....
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Temporal characteristics of astrocytic activation in the TNC in a mice model of pain induced by recurrent dural infusion of inflammatory soup
BackgroundAstrocytic activation might play a significant role in the central sensitization of chronic migraine (CM). However, the temporal...
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Cebranopadol for the Treatment of Chronic Pain
Purpose of ReviewRegardless of the etiology, if pain persists chronically, it can detrimentally impact multiple aspects of a patient’s well-being....
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Pain assessment in autism: updating the ethical and methodological challenges through a state-of-the-art review
Sensory features of autism include hypo- or hyper-reactivity to pain; however, previous studies on pain in autism lead to conflicting results. Here,...
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Corneal neuropathic pain: a review to inform clinical practice
Corneal neuropathic pain (CNP) is a poorly defined disease entity characterised by an aberrant pain response to normally non-painful stimuli and...
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Evaluation of Central Sensitisation in Bladder Pain Syndrome: A Systematic Review
Introduction and HypothesisBladder pain syndrome (BPS) is a debilitating condition characterised by exaggerated bladder sensations and altered...
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Simultaneous hyperbaric oxygen therapy during systemic chemotherapy reverses chemotherapy-induced peripheral neuropathy by inhibiting TLR4 and TRPV1 activation in the central and peripheral nervous system
Background and objectivesChemotherapy-induced peripheral neuropathy (CIPN) is considered one of the most common sequelae in patients with cancer who...
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Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation
BackgroundCentral sensitization is considered a critical pathogenic mechanism of chronic migraine (CM). Activation of microglia in the trigeminal...
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Neuropathic Pain and Spinal Cord Injury: Management, Phenotypes, and Biomarkers
Chronic neuropathic pain after a spinal cord injury (SCI) continues to be a complex condition that is difficult to manage due to multiple underlying...
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Complex Regional Pain Syndrome: A Comprehensive Review
Complex regional pain syndrome (CRPS) is a chronic pain condition often involving hyperalgesia and allodynia of the extremities. CRPS is divided into...
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Mechanism-Based Pharmacological Treatment for Chronic Non-cancer Pain in Adolescents: Current Approaches and Future Directions
Chronic non-cancer pain in pediatrics is a widespread phenomenon that affects about 20% of adolescents (10–19 years old). Although interdisciplinary...
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Lidocaine transdermal patches reduced pain intensity in neuropathic cancer patients already receiving opioid treatment
BackgroundLimited efficacy has been observed when using opioids to treat neuropathic pain. Lidocaine patches reduce neuropathic pain in postherpetic...
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The impact of time from injury to surgery on the risk of neuropathic pain after traumatic spinal cord injury
Traumatic spinal cord injury (SCI) is a devastating neurological disorder often accompanied by neuropathic pain (NeP), significantly affecting...
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Targeting therapy-induced senescence as a novel strategy to combat chemotherapy-induced peripheral neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a treatment-limiting adverse effect of anticancer therapy that complicates the lifestyle of many...
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Frontiers in Acute Pain Management: Emerging Concepts in Pain Pathways and the Role of VX-548 as a Novel NaV1.8 Inhibitor: A Narrative Review
Purpose of ReviewDespite ongoing research into alternative postsurgical pain treatments, opioids remain widely used analgesics regardless of...
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Duhuo Jisheng decoction alleviates neuroinflammation and neuropathic pain by suppressing microglial M1 polarization: a network pharmacology research
BackgroundNeuropathic pain (NP) is the most prevalent form of chronic pain resulting from nerve damage or injury. Despite the widespread use of Duhuo...
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Complex Regional Pain Syndrome (CRPS) and the Value of Early Detection
Purpose of ReviewThe goal of this narrative review is to describe the current understanding of the pathology of Complex Regional Pain Syndrome...
