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Mesenchymal Stem Cell–Based Therapy as a New Approach for the Treatment of Systemic Sclerosis
Systemic sclerosis (SSc) is an intractable autoimmune disease with unmet medical needs. Conventional immunosuppressive therapies have modest efficacy...
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Epidemiology, healthcare utilization, and related costs among patients with IPF: results from a German claims database analysis
BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive form of fibrosing interstitial pneumonia with poor survival. This study provides...
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Treatment of heart failure with preserved ejection fraction with SGLT2 inhibitors: new therapy standard?
Heart failure with preserved ejection fraction (HFpEF) is a common and difficult-to-treat heart disease. Approximately half of patients with heart...
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Digital quantification of p16-positive foci in fibrotic interstitial lung disease is associated with a phenotype of idiopathic pulmonary fibrosis with reduced survival
BackgroundIdiopathic pulmonary fibrosis (IPF) is associated with increased expression of cyclin-dependent kinase inhibitors such as p16 and p21, and...
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The usual Interstitial pneumonia pattern in autoimmune rheumatic diseases
Usual Interstitial Pneumonia (UIP) is characterized by progression of lung parenchyma that may be observed in various autoimmune rheumatic diseases...
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Advances in Targeted Therapy for Progressive Fibrosing Interstitial Lung Disease
Progressive fibrosing interstitial lung disease (PF-ILD) has been redefined as a new clinical syndrome that shares similar genetics, pathophysiology,...
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Lung function trajectories in patients with idiopathic pulmonary fibrosis
BackgroundIdiopathic pulmonary fibrosis (IPF) is a progressive fibrosing interstitial lung disease characterised by decline in lung function. We...
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High-risk population of progressive hepatic fibrosis in chronic hepatitis B patients on antiviral therapy
BackgroundProgressive hepatic fibrosis leads to hepatocellular carcinoma (HCC) and decompensated cirrhosis. The aim of this study was to identify the...
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The economic burden of idiopathic pulmonary fibrosis in Australia: a cost of illness study
PurposeIdiopathic pulmonary fibrosis (IPF) is a type of interstitial lung disease found mostly in elderly persons, characterized by a high symptom...
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Does an Aspirin a Day Take the MASLD Away?
Although aspirin is deeply rooted in the most ancient history of medicine, the mechanism of action of this drug was only identified a few decades...
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Cardiovascular Structural and Functional Parameters in Idiopathic Pulmonary Fibrosis at Disease Diagnosis
IntroductionPrevalence of cardiac and vascular fibrosis in patients with Idiopathic Pulmonary Fibrosis (IPF) has not been extensively evaluated.
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Association between weight loss and mortality in idiopathic pulmonary fibrosis
RationaleIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease that has no cure. Many current research efforts...
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Impact of Myocardial Fibrosis on Cardiovascular Structure, Function and Functional Status in Heart Failure with Preserved Ejection Fraction
Myocardial fibrosis, measured using cardiovascular magnetic resonance extracellular volume (ECV), is associated with adverse outcome in heart failure...
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Body fluid-derived stem cells — an untapped stem cell source in genitourinary regeneration
Somatic stem cells have been obtained from solid organs and tissues, including the bone marrow, placenta, corneal stroma, periosteum, adipose tissue,...
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Current and Future Treatment Landscape for Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) remains a disease with poor survival. The pathogenesis is complex and encompasses multiple molecular pathways....
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Ovarian fibrosis: molecular mechanisms and potential therapeutic targets
Ovarian fibrosis, characterized by the excessive proliferation of ovarian fibroblasts and the accumulation of extracellular matrix (ECM), serves as...
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Current Therapeutic Approaches in Scleroderma: Clinical Models of Effective Antifibrotic Therapies
Purpose of reviewSystemic sclerosis (SSc) is a disease characterized by fibrosis of the skin and internal organs. In this article, we review some of...
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Targeting integrin pathways: mechanisms and advances in therapy
Integrins are considered the main cell-adhesion transmembrane receptors that play multifaceted roles as extracellular matrix (ECM)-cytoskeletal...
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Kidney fibrosis: from mechanisms to therapeutic medicines
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney fibrosis, characterized by excessive extracellular matrix...
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Effect of extracorporeal shockwave therapy for rotator cuff tendinopathy: a systematic review and meta-analysis
BackgroundRotator cuff tendinopathy (RCT) is a widespread musculoskeletal disorder and a primary cause of shoulder pain and limited function. The...
