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A standardized framework for risk-based assessment of treatment effect heterogeneity in observational healthcare databases
Treatment effects are often anticipated to vary across groups of patients with different baseline risk. The Predictive Approaches to Treatment Effect...
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Association of genetic risk and lifestyle with pancreatic cancer and their age dependency: a large prospective cohort study in the UK Biobank
BackgroundPancreatic cancer (PC) is influenced by both genetic and lifestyle factors. However, further research is still needed to comprehensively...
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Racial, Ethnic, and Socioeconomic Differences in Primary Care No-Show Risk with Telemedicine During the COVID-19 Pandemic
BackgroundThe coronavirus 2019 (COVID-19) pandemic resulted in rapid implementation of telemedicine. Little is known about the impact of telemedicine...
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Patients’ preferences for fracture risk communication: the Risk Communication in Osteoporosis (RICO) study
SummaryThe RICO study indicated that most patients would like to receive information regarding their fracture risk but that only a small majority...
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The contribution of sodium reduction and potassium increase to the blood pressure lowering observed in the Salt Substitute and Stroke Study
The Salt Substitute and Stroke Study (SSaSS) demonstrated significant reductions in systolic blood pressure (SBP), and the risk of stroke, major...
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Genetics of Triglyceride-Rich Lipoproteins Guide Identification of Pharmacotherapy for Cardiovascular Risk Reduction
Objective: Despite aggressive reduction of low-density lipoprotein cholesterol (LDL-C), there is a residual risk of cardiovascular disease (CVD)....
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Topical antimicrobial treatment of mesh for the reduction of surgical site infections after hernia repair: a systematic review and meta-analysis
PurposeUse of mesh is essential in hernia repair. A common complication after hernia repair is surgical site infection (SSI), which poses a risk in...
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Effects on cardiovascular risk factors of a low- vs high-glycemic index Mediterranean diet in high cardiometabolic risk individuals: the MEDGI-Carb study
BackgroundThe role of dietary Glycemic Index (GI), independently of fiber intake, in modulating cardiovascular disease (CVD) risk among non-diabetic...
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Mediolateral/lateral episiotomy with operative vaginal delivery and the risk reduction of obstetric anal sphincter injury (OASI): A systematic review and meta-analysis
Introduction and hypothesisOASI complicates approximately 6% of vaginal deliveries. This risk is increased with operative vaginal deliveries (OVDs),...
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Severity of spinal degeneration does not affect the pain reduction under continuous epidural analgesia
PurposeTo outline clinical effectiveness of continuous epidural analgesia (CEA) in patients with failed back surgery syndrome (FBSS) or lumbar spinal...
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Development and validation of a scale to measure hypertensive Chinese individual’s behavior toward salt reduction consumption
ObjectiveThis study aimed to develop and validate the Salt Reduction Behavior Scale (SRBS) to measure the behavior of hypertensive Chinese...
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The Risk Reduction of Accidental Exposure-Related Systemic Allergic Reactions Extrapolated Based on Food Challenge Data After 1 Year of Peanut Oral Immunotherapy
IntroductionThe phase 3 trial PALISADE, comparing peanut ( Arachis hypogaea ) allergen powder-dnfp (PTAH) oral immunotherapy versus placebo in...
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Open reduction versus closed reduction in internal fixation of displaced femoral neck fracture in children: a systematic review and meta-analysis
BackgroundThe quality of reduction is an important factor affecting clinical outcomes for displaced femoral neck fractures (FNFs). However, concerns...
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Exploring machine learning strategies for predicting cardiovascular disease risk factors from multi-omic data
BackgroundMachine learning (ML) classifiers are increasingly used for predicting cardiovascular disease (CVD) and related risk factors using omics...
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Effect of Combined Physical Exercise Training in Reducing Cardiovascular Risk Among Adults with Obesity: A Randomized Clinical Trial
It is necessary to understand the relationship between different models of exercise periodization and the reduction of cardiovascular risk in adults...
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Participation in a High-Risk Program Is Associated with a Diagnosis of Earlier-Stage Disease Among Women at Increased Risk for Breast Cancer Development
BackgroundHigh-risk programs provide recommendations for surveillance/risk reduction for women at elevated risk for breast cancer development. This...
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Cardiovascular risk in diabetes mellitus: epidemiology, assessment and prevention
Cardiovascular diseases (CVDs) are the leading causes of morbidity and mortality in individuals with type 2 diabetes mellitus (T2DM). Secular changes...
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Validation of a breast cancer risk prediction model based on the key risk factors: family history, mammographic density and polygenic risk
PurposeWe compared a simple breast cancer risk prediction model, BRISK (which includes mammographic density, polygenic risk and clinical factors),...
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Risk prediction models for diabetic foot ulcer development or amputation: a review of reviews
BackgroundIn adults with diabetes, diabetic foot ulcer (DFU) and amputation are common and associated with significant morbidity and mortality.
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Utilizing machine learning dimensionality reduction for risk stratification of chest pain patients in the emergency department
BackgroundChest pain is among the most common presenting complaints in the emergency department (ED). Swift and accurate risk stratification of chest...
