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Physiological Aspects of Aging
The aging of the population has focused attention on the special needs of elderly patients. The increasing number of elderly people in the world’s...
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Novel Oral Drug Formulations
The rationale for specialised oral formulations of drugs include prolongation of effect for increased patient convenience and reduction of adverse...
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Pharmacokinetic Drug Interactions with ACE Inhibitors
Angiotensin converting enzyme (ACE) inhibitors which have active moieties excreted mainly in urine require adjustment of either the dose or the...
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Do the Pharmacodynamics of the Nonsteroidal Anti-Inflammatory Drugs Suggest a Role in the Management of Postoperative Pain?
Until recently, nonsteroidal anti-inflammatory drugs (NSAIDs) were regarded as weak analgesic agents with a potent antiplatelet effect that severely...
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Salicylate Intoxication in the Elderly
Aspirin (acetylsalicylic acid) and its salicylate derivatives are effective antipyretic, analgesic, and anti-inflammatory agents that are still very...
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The Problems and Pitfalls of NSAID Therapy in the Elderly (Part I)
Nonsteroidal anti-inflammatory drugs (NSAIDs) are the most commonly prescribed drugs worldwide when grouped by generic categories and account for 3...
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Adverse Drug Reactions
The incidence of adverse drug reactions increases with aging, and the elderly are more likely to suffer serious or fatal reactions. Thus, morbidity...
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Ranitidine
SynopsisRanitidine, a histamine H 2 -receptor antagonist, is now well established as a potent inhibitor of gastric acid secretion effective in the...
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Enalapril
SynopsisEnalapril provides significant haemodynamic, symptomatic and clinical improvement when added to maintenance therapy with digitalis and...