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The Miami Framework for ALS and related neurodegenerative disorders: an integrated view of phenotype and biology
Increasing appreciation of the phenotypic and biological overlap between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia, alongside...
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Adaptive and Maladaptive Clonal Hematopoiesis in Telomere Biology Disorders
Purpose of ReviewTelomere biology disorders (TBDs) are germline-inherited conditions characterized by reduction in telomerase function, accelerated...
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Integrated systems biology analysis of acute lymphoblastic leukemia: unveiling molecular signatures and drug repurposing opportunities
Acute lymphoblastic leukemia (ALL) is a hematological malignancy characterized by aberrant proliferation and accumulation of lymphoid precursor cells...
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Biology of house dust mites and storage mites
House dust mites and storage mites have a high allergenic potential and lead to sensitization through the formation of specific IgE antibodies. Due...
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Application of systems biology-based in silico tools to optimize treatment strategy identification in Still’s disease
BackgroundSystemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD) are manifestations of an autoinflammatory disorder...
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An investigation of 6-Shogaol effects on MCF7 cell lines through a systems biology approach
IntroductionIn the literature, to investigate hormonal mechanisms of cell growth of patients with breast cancer (BC), as the second most common cause...
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Proteome analysis of monocytes implicates altered mitochondrial biology in adults reporting adverse childhood experiences
The experience of adversity in childhood has been associated with poor health outcomes in adulthood. In search of the biological mechanisms...
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Advancements in understanding chicken coccidiosis: from Eimeria biology to innovative control strategies
Coccidiosis, an intestinal disease caused by Eimeria protozoan parasites, affects various animal species, and especially poses a significant threat...
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Translating the Biology of Aging into New Therapeutics for Alzheimer’s Disease: Senolytics
The recent FDA-approval for amyloid lowering therapies reflects an unwavering commitment from the Alzheimer’s disease (AD) research community to...
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The neurovascular unit and systemic biology in stroke — implications for translation and treatment
Ischaemic stroke is a leading cause of disability and death for which no acute treatments exist beyond recanalization. The development of novel...
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System biology approach to delineate expressional difference in the blood mononuclear cells between healthy and Turner syndrome individuals
BackgroundTurner syndrome (TS) is a rare disorder associated either with complete or partial loss of one X chromosome in women. The information on...
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Genetic Counseling and Family Screening Recommendations in Patients with Telomere Biology Disorders
Purpose of ReviewTelomere biology disorders (TBDs) encompass a spectrum of genetic diseases with a common pathogenesis of defects in telomerase...
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Diagnosis and Management of Pulmonary Manifestations of Telomere Biology Disorders
Purpose of ReviewTelomere biology disorders (TBD) are a group of genetic disorders characterized by premature shortening of telomeres, resulting in...
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Pulmonary, Hepatic, and Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Telomere Biology Disorders
Purpose of the ReviewThis study aimed to summarize evidence and provide consensus-based guidelines for management of transplantation in patients with...
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Imagine beyond: recent breakthroughs and next challenges in mammary gland biology and breast cancer research
On 8 December 2022 the organizing committee of the European Network for Breast Development and Cancer labs (ENBDC) held its fifth annual Think Tank...
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A systems biology approach for investigating significantly expressed genes among COVID-19, hepatocellular carcinoma, and chronic hepatitis B
BackgroundWorldwide, COVID-19’s death rate is about 2%, considering the incidence and mortality. However, the information on its complications in...
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Malignant peripheral nerve sheath tumor: models, biology, and translation
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive, invasive cancer that comprise around 10% of all soft tissue sarcomas and develop in...
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Proceedings of the Post-Genome Analysis for Musculoskeletal Biology Workshop
Purpose of the ReviewHerein, we report on the proceedings of the workshop entitled “ Post-Genome analysis for musculoskeletal biology ” that was held...
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Neurotransmitter signaling: a new frontier in colorectal cancer biology and treatment
The brain–gut axis, a bidirectional network between the central and enteric nervous system, plays a critical role in modulating the gastrointestinal...
