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Molecular pathogenesis of the myeloproliferative neoplasms
The Philadelphia negative myeloproliferative neoplasms (MPN) compromise a heterogeneous group of clonal myeloid stem cell disorders comprising...
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In-Hospital and readmission outcomes of patients with myeloproliferative neoplasms and atrial fibrillation: insights from the National Readmissions Database
IntroductionPatients with myeloproliferative neoplasms (MPNs) and atrial fibrillation (AF) are at increased risk of thrombosis and bleeding. However,...
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Contributions of bone marrow monocytes/macrophages in myeloproliferative neoplasms with JAK2V617F mutation
The classic BCR-ABL1-negative myeloproliferative neoplasm (MPN) is a highly heterogeneous hematologic tumor that includes three subtypes, namely...
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Clinicopathologic spectrum of myeloid neoplasms with concurrent myeloproliferative neoplasm driver mutations and SRSF2 mutations
Myeloproliferative neoplasms (MPNs) are frequently associated with classic driver mutations involving JAK2 , MPL or CALR . SRSF2 is among the most...
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Measurement of serum hepcidin-25 by latex agglutination in healthy volunteers and patients with hematologic disorders
Iron is an essential trace metal, vital for various physiologic processes, but excess levels can harm health. Maintaining iron homeostasis is...
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Pathological and genomic features of myeloproliferative neoplasms associated with splanchnic vein thrombosis in a single-center cohort
Here, we reviewed clinical-morphological data and investigated mutational profiles by NGS in a single-center series of 58 consecutive MPN-SVT...
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Role of JAK inhibitors in myeloproliferative neoplasms: current point of view and perspectives
Classic Philadelphia-negative myeloproliferative neoplasms (MPN) include polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis...
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Updates on eosinophilic disorders
This review addresses changes and updates in eosinophilic disorders under the International Consensus Classification (ICC). The previous category of...
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Treatment of Langerhans Cell Histiocytosis and Histiocytic Disorders: A Focus on MAPK Pathway Inhibitors
Histiocytic disorders are rare diseases defined by the clonal accumulation of a macrophage or dendritic cell origin. These disorders include...
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Novel Pathophysiological Mechanisms of Thrombosis in Myeloproliferative Neoplasms
Purpose of ReviewThrombosis remains a leading cause of morbidity and mortality in BCR/ABL negative myeloproliferative neoplasms (MPN). Circulating...
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Interventional treatment of refractory non-traumatic chylous effusions in patients with lymphoproliferative disorders
To report results of interventional treatment of refractory non-traumatic abdomino-thoracic chylous effusions in patients with lymphoproliferative...
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Clinical clues for suspecting wild-type transthyretin cardiac amyloidosis in patients with monoclonal gammopathy of undetermined significance: a case report
BackgroundMyeloproliferative disorders, including monoclonal gammopathy of undetermined significance (MGUS), are often associated with amyloid...
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Obliteration of liver sinusoids through platelet aggregates associated to extramedullary haematopoiesis in myeloid neoplasms
Herein is reported a series of five patients with myeloid neoplasms presenting hepatic complications in whose liver biopsy revealed obstruction of...
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Anti-IL-5 Pathway Agents in Eosinophilic-Associated Disorders Across the Lifespan
Monoclonal antibodies targeting interleukin (IL)-5 pathways have revolutionized the treatment expectations for eosinophilic-associated conditions,...
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Evaluation of the need for cytoreduction and its potential carcinogenicity in children and young adults with myeloproliferative neoplasms
Myeloproliferative neoplasms are rare at a young age, and few reports have described the disease characteristics and outcomes in this group. This...
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Markedly increased small-sized megakaryocytes and platelets count in the circulation with pseudo-hyperkalemia following splenectomy
Megakaryocytes are common in the bone marrow and appear less often in circulation. Most studies on circulatory megakaryocytes have implicated...
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Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane...
