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HPLC fingerprint of flavonoids, enzyme inhibition and antioxidant activity of Newbouldia laevis stem-bark: an in vitro and in silico study
BackgroundMedicinal plant contains multiple bioactive compounds with therapeutic potentials. Due to their availability, affordability, and minimal...
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Dairy-originated digestion-resistant and bioactive peptides increase the risk of hypertension: Tehran Lipid and Glucose Study
Milk-protein-derived bioactive peptides (BPs) have been proposed as modulators of different regulatory processes involved in blood pressure...
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In vitro cestocidal activity of Persicaria hydropiper (L.) Delarbre, a traditionally used anthelmintic plant in India
Persicaria hydropiper is a medicinal plant used for the treatment of helminth infections among the Naga people of India. To verify the traditional...
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Antioxidant and antidiabetic flavonoids from the leaves of Dypsis pembana (H.E.Moore) Beentje & J.Dransf., Arecaceae: in vitro and molecular docking studies
BackgroundOxidative stress and diabetes are medical conditions that have a growing prevalence worldwide, significantly impacting our bodies. Thus, it...
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Antihyperglycemic activity of verbenone and L-arginine in nicotinamide-streptozotocin-induced diabetic mice: in vitro and in vivo studies
BackgroundNatural products are utilized globally for the management of diseases such as diabetes mellitus. Carrot seeds are ethnobotanically used in...
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Network pharmacology and in vitro experimental verification unveil glycyrrhizin from glycyrrhiza glabra alleviates acute pancreatitis via modulation of MAPK and STAT3 signaling pathways
Acute pancreatitis (AP) is a severe gastrointestinal inflammatory disease with increasing mortality and morbidity. Glycyrrhiza glabra, commonly known...
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Quantitative analyses of matrices, osteoblasts, and osteoclasts during bone remodeling using an in vitro system
IntroductionBone remodeling plays a central role in the maintenance of bone homeostasis. Our group has established an in vitro system by which the...
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In vitro and in vivo anthelmintic and chemical studies of Cyperus rotundus L. extracts
BackgroundTrichinellosis, a zoonosis caused by the genus Trichinella , is a widespread foodborne disease. Albendazole, one of the benzimidazole...
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CRISPR/Cas9-mediated knockout of intracellular molecule SHP-1 enhances tumor-killing ability of CD133-targeted CAR T cells in vitro
CAR T cell therapy has been successfully used in the treatment of hematological malignancies, and the strategy that deletion of inhibitory receptor...
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Salvianolic Acid B Attenuates Hypertrophic Scar Formation In Vivo and In Vitro
BackgroundHypertrophic scars (HTSs) are a fibroproliferative disorder that occur following skin injuries. Salvianolic acid B (Sal-B) is an extractant...
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Comparative in vitro treatment of mesenchymal stromal cells with GDF-5 and R57A induces chondrogenic differentiation while limiting chondrogenic hypertrophy
PurposeHypertrophic cartilage is an important characteristic of osteoarthritis and can often be found in patients suffering from osteoarthritis....
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Dexmedetomidine Alters the Inflammatory Profile of Rat Microglia In Vitro
BackgroundMicroglia are a primary mediator of the neuroinflammatory response to neurologic injury, such as that in traumatic brain injury. Their...
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KLF4 Inhibits the Activation of Human Hepatic Stellate Cell In Vitro
ObjectiveHepatic stellate cells (HSCs) play a crucial role in liver fibrosis. Early-stage liver fibrosis is reversible and intimately associated with...
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Antiviral activity of luteolin against porcine epidemic diarrhea virus in silico and in vitro
BackgroundPorcine epidemic diarrhea virus (PEDV) mainly causes acute and severe porcine epidemic diarrhea (PED), and is highly fatal in neonatal...
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In vitro growth (IVG) of human ovarian follicles in frozen thawed ovarian cortex tissue culture supplemented with follicular fluid under hypoxic conditions
BackgroundDespite its clinical success rates, transplantation after ovarian tissue cryopreservation (OTC) remains a matter of concern. Certain cancer...
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L1077P CFTR pathogenic variant function rescue by Elexacaftor–Tezacaftor–Ivacaftor in cystic fibrosis patient-derived air–liquid interface (ALI) cultures and organoids: in vitro guided personalized therapy of non-F508del patients
Cystic fibrosis (CF) is caused by defects of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CFTR-modulating drugs may overcome...
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In vitro investigations on interference of selected probiotic candidates with Campylobacter jejuni adhesion and invasion of primary chicken derived cecal and Caco-2 cells
BackgroundCampylobacter (C.) jejuni is one of the most important bacterial foodborne pathogens worldwide. Probiotics such as Lactobacillus or Bacillus ...
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Does Torulaspora delbrueckii has some probiotic capabilities? In vitro and in vivo assessment
PurposeYeasts are gaining attention as potential emerging tools for enhancing the dietary benefits of food attributes and for preventing food...
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Anti-helminthic effect of Punica granatum peel extract on Trichinella spiralis worms and muscle larvae: in vitro and in vivo studies
Trichinella spiralis ( T. spiralis ) is a prevalent foodborne intestinal parasite in many develo** countries. Albendazole (ABZ) is the drug of choice...
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Phytochemical analysis, in vitro and in silico effects from Alstonia boonei De Wild stem bark on selected digestive enzymes and adipogenesis in 3T3-L1 preadipocytes
BackgroundObesity is a global health issue arising from the unhealthy accumulation of fat. Medicinal plants such as Alstonia boonei stem bark has...
