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From images to insights: a neuroradiologist’s practical guide on white matter fiber tract anatomy and DTI patterns for pre-surgical planning
IntroductionDiffusion tensor imaging (DTI) is a valuable non-invasive imaging modality for map** white matter tracts and assessing microstructural...
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Mechanisms linking obesity and its metabolic comorbidities with cerebral grey and white matter changes
Obesity is a preventable risk factor for cerebrovascular disorders and it is associated with cerebral grey and white matter changes. Specifically,...
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White matter microglia heterogeneity in the CNS
Microglia, the resident myeloid cells in the central nervous system (CNS) play critical roles in sha** the brain during development, responding to...
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Meningeal inflammation as a driver of cortical grey matter pathology and clinical progression in multiple sclerosis
Growing evidence from cerebrospinal fluid samples and post-mortem brain tissue from individuals with multiple sclerosis (MS) and rodent models...
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Short-term exposure to air pollution on peripheral white blood cells and inflammation biomarkers: a cross-sectional study on rural residents
Effects of short-term exposure to ambient air pollution on systemic immunological and inflammatory biomarkers in rural population have not been...
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White Matter Hyperintensity as a Vascular Contribution to the AT(N) Framework
The AT(N) framework enables the classification of an individual within the biological Alzheimer’s disease (AD) continuum by pairing the cognitive...
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Obsessive compulsive symptom dimensions are linked to altered white-matter microstructure in a community sample of youth
Obsessive-compulsive symptoms (OCS) are common in school-aged children and predict the development of obsessive compulsive disorder (OCD)....
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Aquaporin-4 IgG antibodies: predictors of positivity and their relationship with neuropsychiatric disorders and white matter lesions in Juvenile systemic lupus erythematosus
BackgroundThis study aimed to describe the prevalence of the various clinical features and severity of juvenile systemic lupus erythematosus (jSLE)...
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White matter hyperintensities: a possible link between sarcopenia and cognitive impairment in patients with mild to moderate Alzheimer’s disease
PurposeAlzheimer’s disease (AD) has been reported to be associated with sarcopenia. White matter hyperintensities (WMH) are common in AD patients....
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The genetic architecture of fornix white matter microstructure and their involvement in neuropsychiatric disorders
The fornix is a white matter bundle located in the center of the hippocampaldiencephalic limbic circuit that controls memory and executive functions,...
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C-reactive protein and white matter microstructural changes in COVID-19 patients with encephalopathy
Encephalopathy is a neurological complication of COVID-19. The objective of this exploratory study is to investigate the link between systemic...
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White Matter and Alzheimer’s Disease: A Bidirectional Mendelian Randomization Study
IntroductionObservational studies have indicated widespread comorbidity of white matter (WM) lesions and Alzheimer’s disease (AD) in the elderly, but...
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White matter lesion load determines exercise-induced dopaminergic plasticity and working memory gains in aging
Age-related dopamine reductions have been suggested to contribute to maladaptive working memory (WM) function in older ages. One promising...
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Classification of white matter lesions and characteristics of small vessel disease markers
ObjectivesRadiological markers for cerebral small vessel disease (SVD) may have different biological underpinnings in their development. We attempted...
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Understanding the impact of congenital infections and perinatal viral exposures on the develo** brain using white matter magnetic resonance imaging: a sco** review
BackgroundMagnetic Resonance Imaging (MRI)-based imaging techniques are useful for assessing white matter (WM) structural and microstructural...
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Targeting the brain 5-HT7 receptor to prevent hypomyelination in a rodent model of perinatal white matter injuries
Approximately 15 million babies are born prematurely every year and many will face lifetime motor and/or cognitive deficits. Children born...
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Study of the relationship between onset lateralization and hemispheric white matter asymmetry in Parkinson's disease
BackgroundParkinson's disease (PD) is characterized by a lateralized onset, but its cause and mechanism are still unclear.
MethodsObtaining...
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Diffusion basis spectrum imaging detects pathological alterations in substantia nigra and white matter tracts with early-stage Parkinson’s disease
ObjectivesUsing diffusion basis spectrum imaging (DBSI) to examine the microstructural changes in the substantia nigra (SN) and global white matter...
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NODDI, diffusion tensor microstructural abnormalities and atrophy of brain white matter and gray matter contribute to cognitive impairment in multiple sclerosis
BackgroundPathologically specific MRI measures may elucidate in-vivo the heterogeneous processes contributing to cognitive impairment in multiple...
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White matter damage as a consequence of vascular dysfunction in a spontaneous mouse model of chronic mild chronic hypoperfusion with eNOS deficiency
Vascular cognitive impairment and dementia (VCID) is the second most common form of dementia after Alzheimer’s disease (AD). Currently, the...
