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Radiotherapy or systemic therapy versus combined therapy in patients with brain metastases: a propensity-score matched study
AimThis study aimed to evaluate the clinical benefits of systemic therapy (ST) combined with stereotactic radiosurgery (SRS) for brain metastases...
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Optimal first-line treatment strategies of systemic therapy for unresectable gastrointestinal neuroendocrine tumors based on the opinions of Japanese experts.
There are several options for systemic therapy of gastroenteropancreatic neuroendocrine neoplasms (GEP-NEN), including somatostatin analogues (SSA),...
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Small molecule tyrosine kinase inhibitors approved for systemic therapy of advanced hepatocellular carcinoma: recent advances and future perspectives
Liver cancer is the sixth most commonly diagnosed cancer and the third leading cause of cancer death in the world, and hepatocellular carcinoma (HCC)...
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Metastasectomy or Stereotactic Body Radiation Therapy With or Without Systemic Therapy for Oligometastatic Esophagogastric Cancer
BackgroundThe primary goal of this study was to determine overall survival (OS) in patients who underwent local treatment (metastasectomy or...
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Positron emission tomography molecular imaging to monitor anti-tumor systemic response for immune checkpoint inhibitor therapy
Immune checkpoint inhibitors (ICIs) achieve a milestone in cancer treatment. Despite the great success of ICI, ICI therapy still faces a big...
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Right Sizing Systemic Therapy for Patients with Breast Cancer. Where are we Today?
Purpose of ReviewAs outcomes for patients with early-stage breast cancer have improved, oncologists have sought to de-escalate systemic therapy to...
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Screening and treatment of latent tuberculosis in patients with solid tumors and systemic cancer therapy
IntroductionTuberculosis is one of the infectious diseases with greater morbidity and mortality worldwide. Cancer causes an important...
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Rare complication – skin atrophy – after systemic conservative therapy of infantile hemangioma
BackgroundHemangiomas, also called infantile hemangiomas (IH) or hemangiomas of infancy are the most frequently seen benign vascular tumors of...
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Efficacy of transarterial chemoembolization with drug-eluting beads combined with systemic chemotherapy and targeted therapy in colorectal cancer liver metastasis
BackgroundSystemic therapy is the standard treatment for unresectable colorectal cancer with liver metastasis (CRCLM). Transarterial...
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The oligometastatic spectrum in the era of improved detection and modern systemic therapy
Metastases remain the leading cause of cancer-related mortality. The oligometastasis hypothesis postulates that a spectrum of metastatic spread...
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High systemic inflammation as a novel cardiovascular risk factor and target for anti-cytokine therapy: comment regarding the triglyceride glucose index
In the last century, there has been more than enough research that proved the association of high lipid and glucose levels with cardiovascular...
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Survival benefit of nephroureterectomy in systemic therapy exposed metastatic upper tract urinary urothelial carcinoma patients
BackgroundIt is unknown whether the stage of the primary may influence the survival (OS) of metastatic upper tract urothelial carcinoma (mUTUC)...
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Repurposing pantoprazole in combination with systemic therapy in advanced head and neck squamous cell carcinoma: a phase I/II randomized study
Pantoprazole decreases the acidity of the tumor microenvironment by inhibiting proton pumps on the cancer cell. This possibly leads to increased...
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Systemic therapy in children and adolescents with mental disorders: a systematic review and meta-analysis
BackgroundSystemic therapy (ST) is a psychotherapeutic intervention in complex human systems (both psychological and interpersonal). Cognitive...
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Recurrent Colorectal Liver Metastases: Upfront Local Treatment versus Neoadjuvant Systemic Therapy Followed by Local Treatment (COLLISION RELAPSE): Study Protocol of a Phase III Prospective Randomized Controlled Trial
PurposeThe objective of the COLLISION RELAPSE trial is to prove or disprove superiority of neoadjuvant systemic therapy followed by repeat local...
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Serious infections and tuberculosis in psoriasis patients receiving systemic therapy in Korea: a nationwide population-based cohort study
BackgroundPsoriasis itself, as well as its immunomodulatory drugs, may alter the immune system, increasing the risk of infections. Recent research...
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Long-term survival after systemic chemotherapy, chemoradiotherapy, and maintenance therapy for an older adult patient with recurrent pancreatic acinar cell carcinoma
Pancreatic acinar cell carcinoma (PACC) is a rare cancer with no specific treatment. The treatment and chemotherapy for PACC are selected according...
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Determining individual suitability for neoadjuvant systemic therapy in breast cancer patients through deep learning
BackgroundThe survival advantage of neoadjuvant systemic therapy (NST) for breast cancer patients remains controversial, especially when considering...
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Systemic therapy of necrobiotic xanthogranuloma: a systematic review
BackgroundEven though a plethora of systemic therapies have been proposed for necrobiotic xanthogranuloma (NXG), there is no systematic review on...
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Hemodynamic Response to Oral Vasodilator Therapy in Systemic Sclerosis-Related Pulmonary Hypertension
PurposeAlthough classified as group 1 pulmonary arterial hypertension (PAH), patients with systemic sclerosis-related pulmonary hypertension (SSc-PH)...
