Search
Search Results
-
Diagnostic and prognostic significance of miR-320a-3p in patients with chronic heart failure
AimThe purpose of this study was to investigate the diagnostic and prognostic value of miR-320a-3p in chronic heart failure (CHF).
Methods ...
-
Fetal Exosomal Platelet-activating Factor Triggers Functional Progesterone Withdrawal in Human Placenta
In most mammals, labor is heralded by the withdrawal of progesterone. In humans, circulating progesterone levels increase as gestation advances while...
-
Reanalysis of whole-exome sequencing (WES) data of children with neurodevelopmental disorders in a standard patient care context
This study aims to inform future genetic reanalysis management by evaluating the yield of whole-exome sequencing (WES) reanalysis in standard patient...
-
Epigenetic genes and epilepsy — emerging mechanisms and clinical applications
An increasing number of epilepsies are being attributed to variants in genes with epigenetic functions. The products of these genes include factors...
-
Dermatologic Disease-Directed Targeted Therapy (D3T2): The Application of Biomarker-Based Precision Medicine for the Personalized Treatment of Skin Conditions—Precision Dermatology
Precision dermatology uses individualized dermatologic disease-directed targeted therapy (D 3 T 2 ) for the management of dermatoses and for the...
-
A novel therapeutic strategy: the significance of exosomal miRNAs in acute myeloid leukemia
Acute myeloid leukemia (AML) is a fast-growing blood cancer that interferes with the normal growth of blood cells in the bone marrow and blood. It is...
-
O-GlcNAcylation links oncogenic signals and cancer epigenetics
Prevalent dysregulation of epigenetic modifications plays a pivotal role in cancer. Targeting epigenetic abnormality is a new strategy for cancer...
-
MiR-210-3p targets CELF2 to facilitate progression of lung squamous carcinoma through PI3K/AKT pathway
This study examined the internal mechanism of miR-210-3p/CELF2 in LUSC. Expression data of mRNAs and miRNAs in LUSC were acquired from TCGA and...
-
Intrinsic and Extrinsic Factors Governing the Transcriptional Regulation of ESR1
Transcriptional regulation of ESR1 , the gene that encodes for estrogen receptor α (ER), is critical for regulating the downstream effects of the...
-
Maternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a...
-
Regulation of 20α-Hydroxysteroid Dehydrogenase Expression in Term Pregnant Human Myometrium Ex Vivo
Metabolic inactivation of progesterone within uterine myocytes by 20α-hydroxysteroid dehydrogenase (20α-HSD) has been postulated as a mechanism...
-
Research progress on the multi-omics and survival status of circulating tumor cells
In the dynamic process of metastasis, circulating tumor cells (CTCs) emanate from the primary solid tumor and subsequently acquire the capacity to...
-
Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis
BackgroundExercise training, including high-intensity interval training (HIIT), improves rheumatoid arthritis (RA) inflammatory disease activity via...
-
The etiology of congenital diaphragmatic hernia: the retinoid hypothesis 20 years later
AbstractCongenital diaphragmatic hernia (CDH) is a severe birth defect and a major cause of neonatal respiratory distress. Impacting ~2–3 in 10,000...
-
Effects of alternative splicing events and transcriptome changes on kidney stone formation
During the development of urinary stone disease, the formation of tiny crystals that adhere to the renal tubular epithelium induces epithelial cell...
-
Microrna-1224-5p Is a Potential Prognostic and Therapeutic Biomarker in Glioblastoma: Integrating Bioinformatics and Clinical Analyses
ObjectiveGlioblastoma (GBM) is the most common, invasive, and malignant primary brain tumor with a poor prognosis and high recurrence rate. It’s...
-
Zishen Pill alleviates diabetes in Db/db mice via activation of PI3K/AKT pathway in the liver
BackgroundThe rising global incidence of type 2 diabetes mellitus (T2DM) highlights a need for new therapies. The Zishen Pill (ZSP) is a traditional...
-
Interplay between cofactors and transcription factors in hematopoiesis and hematological malignancies
Hematopoiesis requires finely tuned regulation of gene expression at each stage of development. The regulation of gene transcription involves not...
-
AML1/ETO and its function as a regulator of gene transcription via epigenetic mechanisms
The chromosomal translocation t(8;21) and the resulting oncofusion gene AML1/ETO have long served as a prototypical genetic lesion to model and...
-
A novel role of MNT as a negative regulator of REL and the NF-κB pathway
MNT, a transcription factor of the MXD family, is an important modulator of the oncoprotein MYC. Both MNT and MYC are basic-helix–loop–helix proteins...
