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Utility of Technetium-99m methoxyisobutyl isonitrile uptake analysis for prediction of the response to chemotherapy in advanced and relapsed breast cancer
BackgroundTechnetium-99m methoxyisobutyl isonitrile (Tc-SESTAMIBI) is a substrate of P-glycoprotein and multidrug-resistance associated protein in...
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Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML)
Expression of the multidrug resistance proteins P-glycoprotein, encoded by the MDR 1 gene, multidrug resistance-associated protein (MRP1) and the lung...
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Biology and modulation of multidrug resistance (MDR) in hematological malignancies
Drug resistance is one of the most significant impediments in the treatment of hematological malignancies. There have been a number of studies on the...
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Rapid induction of long-lasting drug efflux activity in brain vascular endothelial cells but not malignant glioma following irradiation
The influence of radiotherapy on malignant glioma multidrug resistance to chemotherapy was evaluated because patients with glioma often are treated...
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The Impact of Efflux Transporters in the Brain on the Development of Drugs for CNS Disorders
The development of drugs to treat disorders of the CNS requires consideration of achievable brain concentrations. Factors that influence the brain...
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The Mucosa of the Small Intestine
The intestinal mucosa is capable of metabolising drugs via phase I and II reactions. Increasingly, as a result of in vitro and in vivo (animal and...
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Establishment and comprehensive analysis of a new human transformed follicular lymphoma B cell line, Tat-1
A spontaneously EBV transformed follicular lymphoma (FL) cell line, Tat-1, was established from the lymph node biopsy specimen of a patient with B...
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Entrapment by Cremophor EL decreases the absorption of paclitaxel from the gut
Background: Recent studies in mice and patients have shown that the low oral bioavailability of paclitaxel can be increased by coadministration of...
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Oral Delivery of Taxanes
Oral treatment with cytotoxic agents is tobe preferred as this administration routeis convenient to patients, reducesadministration costs and...
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Pharmacokinetics, tissue distribution, and metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (NSC 707545) in CD2F1 mice and Fischer 344 rats
Purpose: 17-(Dimethylaminoethylamino)-17-demethoxygeldanamycin (17DMAG) is an analogue of the benzoquinone ansamycin compound...
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A reexamination of PSC 833 (Valspodar) as a cytotoxic agent and in combination with anticancer agents
Background : The cyclosporins have been thought as being mainly immunosuppressive agents which interfere with the function of the MDR pump and thus...
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Taxol-induced ceramide generation and apoptosis in human breast cancer cells
Purpose: Taxol has emerged as a valuable antimitotic chemotherapeutic agent, particularly in advanced breast and ovarian cancers. Although much is...
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Overcoming drug resistance in ovarian carcinoma
Advanced epithelial ovarian carcinoma is treated with cytoreductive surgery and combination chemotherapy with a platinum compound and paclitaxel....
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A phase I and pharmacokinetic study of bi-daily dosing of oral paclitaxel in combination with cyclosporin A
Purpose : To investigate dose escalation of bi-daily (b.i.d.) oral paclitaxel in combination with cyclosporin A in order to improve and prolong the...
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Drug Interactions of Paclitaxel and Docetaxel and their Relevance for the Design of Combination Therapy
The taxanes' interaction with otheranticancer drugs have been extensivelyinvestigated in in vitro and inanimal models as well as in humans due tothe...
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Development of Multidrug-Resistance Convertors: Sense or Nonsense?
This review describes the clinical relevance of the two drugtransporters P-glycoprotein (Pgp) and multidrugresistance-associated protein (MRP) and...
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The Oral Route for the Administration of Cytotoxic Drugs: Strategies to Increase the Efficiency and Consistency of Drug Delivery
There is an increasing interest to administer cytotoxic drugs topatients by the oral route. Quality of life issues, treatmentadvantages and...
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Plasma pharmacokinetics and tissue distribution of 17-(allylamino)-17-demethoxygeldanamycin (NSC 330507) in CD2F1 mice1
Purpose: 17-(Allylamino)-17-demethoxygeldanamycin (17AAG) is a benzoquinone ansamycin compound agent that has entered clinical trials. Studies were...
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Constitutive and acquired resistance to calcineurin inhibitors in renal transplantation: role of P-glycoprotein-170
The present study examines whether resistance to Cyclosporin A (CyA) and Tacrolimus (FK506) develops in T cells from individual patients and the...
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Promising Approaches in Acute Leukemia
In the last few decades, there has been a significant improvement in theprognosis of patients with acute leukemias. Still, the majority ofpatients...