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Estimating anchor-based minimal important change using longitudinal confirmatory factor analysis
PurposeThe minimal important change (MIC) is defined as the smallest within-individual change in a patient-reported outcome measure (PROM) that...
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Polygenic risk scores of lithium response and treatment resistance in major depressive disorder
Treatment response and resistance in major depressive disorder (MDD) are suggested to be heritable. Due to significant challenges in defining...
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Functional data analysis to characterize disease patterns in frequent longitudinal data: application to bacterial vaginal microbiota patterns using weekly Nugent scores and identification of pattern-specific risk factors
BackgroundTechnology advancement has allowed more frequent monitoring of biomarkers. The resulting data structure entails more frequent follow-ups...
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Swedish Normative Scores for the BREAST-Q Reduction/Mastopexy Module
BackgroundNorm values for patient reported outcomes, that is knowledge about how the general population of women rate their breast-related...
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Generalized pairwise comparisons of prioritized outcomes are a powerful and patient-centric analysis of multi-domain scores
BackgroundGeneralized pairwise comparisons (GPC) can be used to assess the net benefit of new treatments for rare diseases. We show the potential of...
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Prognostic modeling in early rheumatoid arthritis: reconsidering the predictive role of disease activity scores
ObjectiveIn this prospective cohort study, we provide several prognostic models to predict functional status as measured by the modified Health...
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Dynamic early warning scores for predicting clinical deterioration in patients with respiratory disease
BackgroundThe National Early Warning Score-2 (NEWS-2) is used to detect patient deterioration in UK hospitals but fails to take account of the...
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Plasma biomarkers for prediction of Alzheimer’s disease neuropathologic change
While plasma biomarkers for Alzheimer’s disease (AD) are increasingly being evaluated for clinical diagnosis and prognosis, few population-based...
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Diet quality scores associated with improved cardiometabolic measures among African American adolescents
BackgroundThe Reversing the Negative cardiovascular Effects on Weight (ReNEW) Clinic is a prospective cohort study in children and adolescents (≤21...
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Post-recovery health domain scores among outpatients by SARS-CoV-2 testing status during the pre-Delta period
BackgroundSymptoms of COVID-19 including fatigue and dyspnea, may persist for weeks to months after SARS-CoV-2 infection. This study compared...
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Two for the GOES: Exploring Gambling Outcome Expectancies Scores Across Mixed and Offline-Only Gamblers in Relation to Problem Gambling Risk Status
As online gambling becomes more prevalent, understanding the motives of online gamblers has become a key focus for research and practice. The aim of...
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Correlated physical and mental health composite scores for the RAND-36 and RAND-12 health surveys: can we keep them simple?
BackgroundThe RAND-36 and RAND-12 (equivalent to versions 1 of the SF-36 Health Survey and SF-12 Health Survey, respectively) are widely used...
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Plasma ceramides are associated with MRI-based liver fat content but not with noninvasive scores of liver fibrosis in patients with type 2 diabetes
BackgroundThere is growing evidence that ceramides play a significant role in the onset and progression of non-alcoholic fatty liver disease (NAFLD),...
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Heart failure-type symptom scores in chronic kidney disease: The importance of body mass index
ObjectivesThis analysis sought to determine factors (including adiposity-related factors) most associated with HF-type symptoms (fatigue, shortness...
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Identifying meaningful change on PROMIS short forms in cancer patients: a comparison of item response theory and classic test theory frameworks
BackgroundThis study compares classical test theory and item response theory frameworks to determine reliable change. Reliable change followed by...
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Development and application of a weighted change score to evaluate interventions for vasomotor symptoms in patients with breast cancer using regression trees: a cohort study
PurposeVasomotor symptoms (VMS) are common among individuals with breast cancer (BC) and poorly managed symptoms are associated with reduced quality...
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Helpfulness of the liver disease scores in cardiac surgery for cirrhotic patients
ObjectivesLiver cirrhosis is a well-known risk factor of mortality after cardiac surgery, but not considered in the widely used EuroSCOREII (ESII)....
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Evaluation of different approaches to define expert benchmark scores for new robotic training simulators based on the Medtronic HUGO™ RAS surgical robot experience
New robot-assisted surgery platforms being developed will be required to have proficiency-based simulation training available. Scoring methodologies...
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Dynamic change in genome-wide methylation in response to increased suicidal ideation in schizophrenia spectrum disorders
Suicide is a significant public health crisis, with 800,000 people dying annually. Most people completing suicide have previous psychiatric...
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Association between changes in pain or function scores and changes in scapular rotations in patients with subacromial shoulder pain: a prospective cohort study
BackgroundScapular dyskinesis is reported as one of the potential factors contributing to the presentation of pain in subacromial shoulder pain. In...
