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Classification of 18F-Flutemetamol scans in cognitively normal older adults using machine learning trained with neuropathology as ground truth
PurposeEnd-of-life studies have validated the binary visual reads of 18 F-labeled amyloid PET tracers as an accurate tool for the presence or absence...
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Cortical microstructural associations with CSF amyloid and pTau
Diffusion MRI (dMRI) can be used to probe microstructural properties of brain tissue and holds great promise as a means to non-invasively map...
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[18F]F13640: a selective agonist PET radiopharmaceutical for imaging functional 5-HT1A receptors in humans
PurposeF13640 (a.k.a. befiradol, NLX-112) is a highly selective 5-HT 1A receptor ligand that was selected as a PET radiopharmaceutical-candidate...
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The synergistic effect of PET/MRI in whole-body oncologic imaging: an Expert Review
PurposePositron emission tomography (PET)/magnetic resonance imaging (MRI) is a hybrid imaging modality that combines MRI and PET imaging into a...
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PET/MRI Radiomics in Rectal Cancer: a Pilot Study on the Correlation Between PET- and MRI-Derived Image Features with a Clinical Interpretation
PurposeThe aim of this study was to explore possible correlations among different imaging features from 2-deoxy-2-[ 18 F]fluoro-D-Glucose positron...
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Harmonisation of PET/CT contrast recovery performance for brain studies
PurposeIn order to achieve comparability of image quality, harmonisation of PET system performance is imperative. In this study, prototype...
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Simultaneous 18F-FDG PET/MR metabolic and structural changes in visual snow syndrome and diagnostic use
PurposeVisual snow syndrome (VSS) is a recently recognized chronic neurologic condition characterized by the constant perceiving of tiny flickering...
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Bottom-of-sulcus dysplasia: the role of 18F-FDG PET in identifying a focal surgically remedial epileptic lesion
PurposeBottom-of-sulcus dysplasia (BOSD) is a type of focal cortical dysplasia and an important cause of intractable epilepsy. While the MRI features...
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APOEε4 potentiates the relationship between amyloid-β and tau pathologies
APOEε4 is the most well-established genetic risk factor for sporadic Alzheimer’s disease and is associated with cerebral amyloid-β. However, the...
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Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases
PurposeIn vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of...
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Karawun: a software package for assisting evaluation of advances in multimodal imaging for neurosurgical planning and intraoperative neuronavigation
PurposeThe neuroimaging research community—which includes a broad range of scientific, medical, statistical, and engineering disciplines—has...
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Phase I study to assess safety, biodistribution and radiation dosimetry for 89Zr-girentuximab in patients with renal cell carcinoma
PurposeIn this phase I study, we evaluated the safety, biodistribution and dosimetry of [ 89 Zr]Zr-DFO-girentuximab ( 89 Zr-girentuximab) PET/CT imaging...
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A predictive model using the mesoscopic architecture of the living brain to detect Alzheimer’s disease
BackgroundAlzheimer’s disease, the most common cause of dementia, causes a progressive and irreversible deterioration of cognition that can sometimes...
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Improving staging of rectal cancer in the pelvis: the role of PET/MRI
PurposeThe role of positron emission tomography/magnetic resonance (PET/MR) in evaluating the local extent of rectal cancer remains uncertain. This...
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68Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in patients with pancreatic neuroendocrine well-differentiated tumours
PurposeTo explore the role of fully hybrid 68 Ga-DOTATOC PET/MR imaging and radiomic parameters in predicting histopathological prognostic factors in...
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Adaptive working memory training does not produce transfer effects in cognition and neuroimaging
Despite growing interest in cognitive interventions from academia and industry, it remains unclear if working memory (WM) training, one of the most...
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Benzodiazepine use and neuroimaging markers of Alzheimer’s disease in nondemented older individuals: an MRI and 18F Florbetapir PET study in the MEMENTO cohort
Recent evidence suggests an association between benzodiazepines (BZDs) use and lower brain amyloid load, a hallmark of AD pathophysiology. Other...
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Serotonin transporter binding in major depressive disorder: impact of serotonin system anatomy
Serotonin transporter (5-HTT) binding deficits are reported in major depressive disorder (MDD). However, most studies have not considered serotonin...
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Reduced cerebello-cerebral functional connectivity correlates with disease severity and impaired white matter integrity in Friedreich ataxia
Friedreich ataxia (FRDA) is a rare, inherited neurodegenerative disease characterised in most cases by progressive and debilitating motor...